Genetic Variance and Heritability of Serum Cholesterol and Triglycerides Among Chinese Twin Neonates

Chen, C. J.; Yu, M.W.; Wang, Chi-Jane; Tong, S. L.; Tien, Ming-Chun; Lee, T. Y.; Lue, Hung-Chi; Huang, Fu‐Yuan; Lan, Ching; Yang, Kuen-Cheh; Wang, H. C.; Shih, Hong-Mou; Liu, C. Y.; Chen, J. S.

doi:10.1017/s000156600000564x

Cited by 6 publications

(1 citation statement)

References 11 publications

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“…Corey et al [12] found that the variance of total plasma cholesterol in cord blood, which has a higher percentage of HDL-C than in adults, was significantly greater in dichorionic MZ twins than in the cord blood of monochorionic MZ twins. Chen et al [9] reported slightly higher, but nonsignificant within-pair differences in cord blood HDL-C and total cholesterol in dichorionic vs monochorionic MZ twins. Greater variance of dichorionic than monochorionic twins could account for the greater DZ than MZ variance in the NHLBI twins because all DZ twins are dichorionic and only one-third of MZ twins are dichorionic [8].…”

Section: Introductionmentioning

confidence: 94%

Influence of Placentation on High Density Lipoproteins in Adult Males: The NHLBI Twin Study

Reed

Christian

Wood

et al. 1991

Acta genet. med. gemellol.: twin res.

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Dizygotic (DZ) World War II veteran twins who participated in the National Heart Lung and Blood Institute (NHLBI) Twin Study have been reported to have greater variance than monozygotic (MZ) twins for plasma high-density lipoprotein cholesterol (HDL-C), cholesterol in the low-density fraction of HDL (HDL2-C) and apolipoprotein A-I, a major protein component of HDL. It was hypothesized that a possible source of this difference in zygosity variance could be prenatal environmental influences related to placental type. Dermatoglyphics were used to provide a retrospective index of placental type in a subset of the NHLBI MZ twins aged 59-70. The MZ twins classified as dichorionic were found to have significantly greater within-pair variability than the monochorionic MZ twins for HDL-C, HDL2-C and Apo A-I. These findings indicate that intrauterine environmental influences on HDL are manifest later in life.

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Section: Introductionmentioning

confidence: 94%

Influence of Placentation on High Density Lipoproteins in Adult Males: The NHLBI Twin Study

Reed

Christian

Wood

et al. 1991

Acta genet. med. gemellol.: twin res.

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Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease

Chen

Hsiao

et al. 2017

Oncotarget

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Single nucleotide polymorphisms (SNPs) in renin-angiotensin system (RAS) genes are associated with RAS imbalance and chronic kidney disease (CKD). We performed a case-control study and meta-analysis to investigate the association between angiotensinogen (AGT) M235T polymorphism and CKD. A total of 634 patients with end-stage renal disease and 739 healthy controls were studied. We also searched PubMed and the Cochrane Library to identify prospective observational studies published before December 2015. We found that the TT and MT genotypes were associated with a higher risk of CKD than the MM genotype (odds ratio [OR]: 3.56; 95% confidence interval [CI]: 1.14–11.16 and OR: 2.93; 95% CI: 0.91–9.46, respectively). Thirty-eight study populations were included in the meta-analysis. The T allele was associated with a higher risk of CKD than the M allele in all populations (OR: 1.19; 95% CI: 1.08–1.32). The OR was 1.33 in Asians (95% CI: 1.06–1.67) and 1.10 in Caucasians (95% CI: 1.02–1.18). Evaluation of gene-gene and gene-environment interactions using epistasis analysis revealed an interaction between AGT M235T and angiotensin II receptor type 1 A1166C in CKD (OR: 0.767; 95% CI: 0.609–0.965). Genetic testing for CKD in high-risk individuals may be an effective strategy for CKD prevention.

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How Genetic and Environmental Factors Influence Cardiometabolic Risk Factors? Findings from the Isfahan Twins Study

Gharipour

Dianatkhah

Jahanfar

et al. 2023

Preprint

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Background: Disease-discordant twins are excellent subjects for matched case-control studies since the confounding effects of age, sex, genetic background, intrauterine, and early environment factors are perfectly controlled. We aimed to investigate how genetic and environmental factors influence cardiometabolic risk factors in a sample of twins in Iran. Methods: Past medical history and physical examination were collected for all participants. Fasting venous blood samples were taken to measure fasting blood glucose (FBG) and lipids levels. Descriptive statistical analysis was used to present the characteristics of twin pairs. Bivariate correlations between the same age- and gender-corrected parameters were separately analysed in monozygotic and dizygotic pairs. The ACE model i.e., the additive genetic (A) effects, and common (C), and unique (E) environmental influences on the trait was used to assess heritability as a structural equation model. Results: This cross-sectional study included 710 (210 monozygotic and 500 dizygotic) twin pairs (Range age: 2-52 years) (mean age: 11.67 ± 10.71 years) who enrolled in the Isfahan Twin Registry (ITR) in 2017. In early childhood (2-6 years), shared environmental influenced on height (by 76%), weight (by 75%), and body mass index (BMI) (by73%). In late childhood (7-12 years), hip circumference, waist circumference (WC), and LDL-cholesterol are highly heritable, 90%, 76%, and 64%, respectively. In adolescents, the following risk factors were highly or moderately heritable: height (94%), neck circumference (85%), LDL-cholesterol (81%), WC (70%), triglycerides (69%), weight (68%), and BMI (65%). In adult twins, arm circumference (97%), weight (86%), BMI (82%), and neck circumference (81%) were highly heritable. Conclusion: In our study, we observed that various factors, both genetic and environmental, exert an impact on individuals at different stages of their lives. Particularly, we found that certain traits, such as obesity, are highly heritable during childhood but their heritability tends to decline as one progresses into adulthood.

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Genetic Variance and Heritability of Serum Cholesterol and Triglycerides Among Chinese Twin Neonates

Cited by 6 publications

References 11 publications

Influence of Placentation on High Density Lipoproteins in Adult Males: The NHLBI Twin Study

Influence of Placentation on High Density Lipoproteins in Adult Males: The NHLBI Twin Study

Angiotensin II receptor type 1 A1166C modifies the association between angiotensinogen M235T and chronic kidney disease

How Genetic and Environmental Factors Influence Cardiometabolic Risk Factors? Findings from the Isfahan Twins Study

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