Genetic variant in APE1 gene promoter contributes to cervical cancer risk

Wang, Miaomiao; Chu, Haiyan; Wang, Shizhi; Wang, Meilin; Wang, Wei; Han, Song; Zhang, Zhengdong

doi:10.1016/j.ajog.2013.07.010

Cited by 21 publications

(22 citation statements)

References 36 publications

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“…As the most frequently assessed variant, the APEX1 Asp148Glu polymorphism is thought to be associated with many cancers [14–16, 23–25, 27]. As for its biological function, APEX1 is related to a greater sensitivity to ionizing radiation, thus inducing mitotic delay in lymphocytes [33].…”

Section: Discussionmentioning

confidence: 99%

“…In 2013, Pan et al [13] suggested that the APEX1 gene might be one of risk factors contributing to the morbidity of lung cancer. In addition, other diseases, such as cervical cancer [14], ovarian cancer [15], and colorectal cancer [16] have also been associated with APEX1 gene polymorphisms.…”

Section: Introductionmentioning

confidence: 99%

“…There are several polymorphisms in the APEX1 gene, of which Asp148Glu (rs1130409) has been associated with many cancers [14–16, 23–25, 27]. In 2001, Hu et al [33] conducted a study on the association between variants of APE1 and ionizing radiation, which suggested that the G allele transformed from T (Asp > Glu) is associated with mitotic delay in lymphocytes, providing greater sensitivity to ionizing radiation.…”

Section: Introductionmentioning

confidence: 99%

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Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis

Chen

2016

Oncotarget

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BackgroundProstate cancer (Pca) is a serious disease associated with considerable morbidity and mortality. As a causative factor, the Asp148Glu polymorphism has been identified in the apurinic/apyrimidinic endonuclease (APEX1) gene. However, the association among Asians is considered controversial.MethodsEvidence for this association was obtained from the PubMed, Embase, HuGENet and Chinese National Knowledge Infrastructure (CNKI) databases. In the analysis, four models were applied. Associations between the APEX1 polymorphism and the invasiveness of Pca based on the Gleason score, prostate-specific antigen expression and clinical status were also evaluated.ResultsSeven articles were included in the analysis. Positive results were not only discovered in the pooled analysis, but also among patients of mixed descentand Asian descent. However, after considering the Hardy-Weinberg equilibrium (HWE), we observed only a 1.557-fold increase in Pca risk for subjects of Asian descent(GG vs. TT: OR=1.557, 95%CI=1.069-2.268) under the co-dominant model. Additionally, we did not also find any relationship between the APEX1 Asp148Glu polymorphism and invasive Pca risk.ConclusionOn the basis of the function of the APEX1 Asp148Glu polymorphism, recent studies, and our results, we suggest that the APEX1 Asp148Glu polymorphism might be important in stimulating the development of Pca rather than its invasiveness in various populations, especially for Asians.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis

Chen

2016

Oncotarget

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“…The APE1 −656T > G in the promoter region is another widely studied polymorphism which is suggested to influence the gene expression at the transcriptional level. The functionally significant −656T > G polymorphism of APE1 contributes to the susceptibility to breast and cervical cancers [121, 122]. In contrast, the −656T > G polymorphism shows a decreased risk of bladder cancer [123].…”

Section: Ape1 In Human Pathologiesmentioning

confidence: 99%

Human AP Endonuclease 1: A Potential Marker for the Prediction of Environmental Carcinogenesis Risk

Park

Kim

et al. 2014

Oxidative Medicine and Cellular Longevity

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Human apurinic/apyrimidinic endonuclease 1 (APE1) functions mainly in DNA repair as an enzyme removing AP sites and in redox signaling as a coactivator of various transcription factors. Based on these multifunctions of APE1 within cells, numerous studies have reported that the alteration of APE1 could be a crucial factor in development of human diseases such as cancer and neurodegeneration. In fact, the study on the combination of an individual's genetic make-up with environmental factors (gene-environment interaction) is of great importance to understand the development of diseases, especially lethal diseases including cancer. Recent reports have suggested that the human carcinogenic risk following exposure to environmental toxicants is affected by APE1 alterations in terms of gene-environment interactions. In this review, we initially outline the critical APE1 functions in the various intracellular mechanisms including DNA repair and redox regulation and its roles in human diseases. Several findings demonstrate that the change in expression and activity as well as genetic variability of APE1 caused by environmental chemical (e.g., heavy metals and cigarette smoke) and physical carcinogens (ultraviolet and ionizing radiation) is likely associated with various cancers. These enable us to ultimately suggest APE1 as a vital marker for the prediction of environmental carcinogenesis risk.

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“…The G allele-containing genotypes of the polymorphism-656T>G in the promoter of the APE1 gene are associated with decreased risk for cervical cancer and breast cancer [138,139]. (T>C) and rs3218373 (G>T)) and the Arg188His (rs3218536) polymorphism in exon 3are at reduced risk for bladder cancer compared to carriers of the more common allele [125].…”

Section: Xrcc1 Genementioning

confidence: 99%

Individual capacity for detoxification of genotoxic compounds and repair of DNA damage. Commonly used methods for assessment of capacity for DNA repair

Chakarov¹,

Petkova²,

Russev³

2014

Biodiscovery

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The first part of this paper reviews the major achievements in the rapidly expanding field of research of individual capacity for repair of genotoxic damage. The issues of individual repair capacity are addressed from mul ple sides, analyzing the impact of the heritable components of the capacity for detoxifica on of genotoxic compounds, on the one hand (determining the risk for occurrence of DNA damage) and of the capacity for repair of DNA damage (when it has already occurred), on the other hand. The role of the capacity for repair of damage to DNA is discussed in the cons tu on of the risk for development of disease (mainly cancer, but also other common diseases and condi ons, such as diabetes, atherosclerosis and cardiovascular disease) and as a major factor in the outcomes of genotoxic therapies (eligibility for therapy with specific agents, risk for severe adverse effects, post-therapeu c survival rates, etc.). The paper contains an extensive list of biomarkers (mainly DNA polymorphisms, but also enzymes and other phenotypic markers, such as markers of the capacity for self-renewal of cell popula ons) that may be poten ally applicable in the assessment of the risk for carcinogenesis or for development other types of human disease.The second part of the paper provides a brief glimpse of the basic methodology used to obtain experimental results in assessment of the efficiency of DNA repair in living cells for research and diagnos c purposes.Cita on: Chakarov S, Petkova R, Russev GCh. Individual capacity for detoxifica on of genotoxic compounds and repair of DNA damage. Commonly used methods for assessment of capacity for DNA repair.

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Genetic variant in APE1 gene promoter contributes to cervical cancer risk

Cited by 21 publications

References 36 publications

Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis

Association between the APEX1 Asp148Glu polymorphism and prostate cancer, especially among Asians: a new evidence-based analysis

Human AP Endonuclease 1: A Potential Marker for the Prediction of Environmental Carcinogenesis Risk

Individual capacity for detoxification of genotoxic compounds and repair of DNA damage. Commonly used methods for assessment of capacity for DNA repair

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