Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review

Abstract

SummaryThe extent to which genetic variations contribute to interindividual differences in weight loss and metabolic outcomes after bariatric surgery is unknown. Identifying genetic variants that impact surgery outcomes may contribute to clinical decision making. This review evaluates current evidence addressing the association of genetic variants with weight loss and changes in metabolic parameters after bariatric surgery. A search was conducted using Medline, Embase, Scopus, Web of Science, and Cochrane Library. Fifty‐two eligible studies were identified. Single nucleotide polymorphisms (SNPs) at ADIPOQ (rs226729, rs1501299, rs3774261, and rs17300539) showed a positive association with postoperative change in measures of glucose homeostasis and lipid profiles (n = 4), but not with weight loss after surgery (n = 6). SNPs at FTO (rs11075986, rs16952482, rs8050136, rs9939609, rs9930506, and rs16945088) (n = 10) and MC4R (rs11152213, rs476828, rs2229616, rs9947255, rs17773430, rs5282087, and rs17782313) (n = 9) were inconsistently associated with weight loss and metabolic improvement. Four studies examining the UCP2 SNP rs660339 reported associations with postsurgical weight loss. In summary, there is limited evidence supporting a role for specific genetic variants in surgical outcomes after bariatric surgery. Most studies have adopted a candidate gene approach, limiting the scope for discovery, suggesting that the absence of compelling evidence is not evidence of absence.

Are weight loss and metabolic outcomes of bariatric surgery influenced by candidate glucocorticoid receptor gene polymorphisms? A prospective study

“…Genome-wide association studies have found many SNP loci that are significantly correlated with variation in response to dietary interventions for weight loss [ 16 ]. Genetic variations may also contribute to inter-individual differences in weight loss and metabolic outcomes as well as weight regain after bariatric surgery [ 17 , 18 , 20 ]. In a small study, researchers found a correlation between weight regain and specific genetic variations among patients.…”

Physiological Appetite Regulation and Bariatric Surgery

“…In a recent review, van der Meer et al [ 230 ] suggest that there is limited evidence supporting a role for genetic variants in outcomes following bariatric surgery. They suggest that more evidence and studies are needed to replicate findings across sexes and ethnicities.…”