Genetic variants in HLA-DP/DQ contribute to risk of acute myeloid leukemia: A case-control study in Chinese

Cao, Shougen; Wu, Yifei; Qian, Xifeng; Ma, Hongxia

doi:10.1016/j.prp.2020.152829

Cited by 4 publications

(3 citation statements)

References 33 publications

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“…These results are in accordance with many researchers who found statistically significant association between cancer risk and HLA-DP rs3077 polymorphisms [ 5 , 6 , 17 – 19 ]. HLA-DP rs3077 and rs9277535 were reported as susceptibility markers for cervical cancer among Chinese females [ 5 ].…”

Section: Discussionsupporting

confidence: 93%

“…They found that HLA-DP rs3077 SNP is markedly associated with cervical cancer risk (OR = 1.37, 95% CI = 1.04–1.80). Cao et al [ 19 ] have investigated the association between HLA-DP/DQ SNP and acute myeloid leukemia (AML) risk. They have genotyped HLA-DP (rs3077 G > A and rs9277535 G > A) and HLA-DQ (rs2856718 A > G and rs7453920 G > A) in a case-control study using real-time PCR.…”

Section: Discussionmentioning

confidence: 99%

“…Prostate Cancer ey found that HLA-DP rs3077 SNP is markedly associated with cervical cancer risk (OR � 1.37, 95% CI � 1.04-1.80). Cao et al [19] have investigated the association between HLA-DP/DQ SNP and acute myeloid leukemia (AML) risk.…”

Section: Discussionmentioning

confidence: 99%

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The Weight of HLA-DPA1 rs3077 Single Nucleotide Polymorphism in Prostate Cancer, a Multicenter Study

2021

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Prostate cancer (PCa) has almost the highest genetic transmission that mimics an autosomal dominance hereditary pattern of cancers in some families. Its incidence in Arab countries was reported to be steadily increasing. Aim. To determine the relevance of HLA-DPA1 rs3077 (A/G) SNP with prostate cancer’s risk and/or severity. Subjects and Methods. Forty PCa patients and forty age matched patients with benign prostatic hyperplasia (BPH), as a control group, were enrolled in the study. Serum levels of urea, creatinine, total prostate-specific antigen (PSA), and free PSA were measured. PSA ratio was determined as well. Genotyping of HLA-DPA1 rs3077 (A/G) SNP was done using real-time PCR. Results. The measured lab parameters, except free PSA, were significantly higher among PCa patients in comparison to controls ( P < 0.001 ∗ ). Moreover, PSA ratio was significantly high among PCa patients ( P < 0.001 ∗ ). HLA-DPA1 rs3077 GG genotype was more frequent in PCa patients and the associated OR was 2.546 ( P = 0.059 ), while AA genotype was more frequent in the control group and the associated OR was 0.145 ( P = 0.081 ). Frequency of G allele was higher among PCa patients than the control group while A allele frequency was significantly decreased ( P = 0.034 ∗ ) (protective allele). On multivariate analysis, there is no significant correlation found between HLA-DPA1 rs3077 SNP and PSA ratio (OR = 4.5, 95% CI = 1.2–17.4, P = 0.856 ). Conclusion. HLA-DPA1 rs3077 G allele could be a risk factor for prostate cancer. However, HLA-DPA1 rs3077 SNP has no relation to PCa severity.

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