Genetic variants in the HLA-G region are associated with Kawasaki disease

Kim, Jae-Jung; Hong, Soo‐Jong; Hong, Young Mi; Kim, Sun; Kang, Mi‐Jin; Kim, Kwi-Joo; Seo, Euri; Yoo, Han‐Wook; Cheong, Hyun-Sub; Shin, Hyoung-Doo; Park, In-Sook; Lee, Jong-Keuk

doi:10.1016/j.humimm.2008.10.002

Cited by 34 publications

(21 citation statements)

References 26 publications

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“…6 The phenomenon of recurrence of KD, along with higher risk of KD in first-degree relatives, has suggested a potential genetic predisposition to KD. 5,[7][8][9][10] Recent studies have uncovered potential genetic polymorphisms associated with either higher risk of KD [11][12][13] or increased frequency of coronary artery abnormalities after KD. 14,15 Some reports have shown that younger children and children who received i.v.…”

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confidence: 99%

Rate, associated factors and outcomes of recurrence of Kawasaki disease in Ontario, Canada

Chahal

Somji

Manlhiot

et al. 2012

Pediatrics International

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Background: Previous studies on recurrence of Kawasaki disease (KD) have mostly been limited to Japan, which has an incidence of KD 8-10-fold higher than North America. The aim of the present study was to determine the rate of KD recurrence for patients in Ontario, to identify factors potentially associated with increased odds of recurrence, and to compare the clinical course and outcomes of index and recurrent KD episodes. Methods: Review was undertaken of all patients with recurrence of KD identified in Ontario, Canada, from 1995 to 2006. All patients with recurrence of KD (defined as at least three clinical signs of KD in addition to fever 35 days), presenting 314 days after the return to baseline from the index episode were included. Results: A total of 1010 patients were followed for 5786 patient-years. During this period a total of 17 recurrent episodes in 16 patients were identified at a median of 1.5 years after the initial episode (2 weeks-5 years). Rate of recurrence of KD was 2.9 episodes/1000 patient-years, which is higher than the expected annual incidence of KD in the same age group (26.2/100 000 per year). No factors associated with increased risk of recurrence were identified, perhaps due to the small number of events. Clinical course and outcomes of the index and recurrent KD episodes were similar. Conclusions:A previous history of KD should increase the index of suspicion for future episodes of KD to allow for rapid recognition, treatment and to achieve optimal outcomes.Key words coronary artery abnormalities, genetics, Kawasaki disease, recurrence.Recurrence after Kawasaki disease (KD) is a well-established phenomenon. 1 Recurrence of KD is thought to affect approximately 4% of children who have had KD in Japan.2 Populationbased studies conducted in the early 1980s have established the prevalence of recurrence of KD in the USA at <1%; these estimates have not been re-evaluated since. 3,4 Estimates have also shown that the risk of having a second episode of KD for children with a previous history of KD is higher than the risk for children in the general population of having an initial episode of KD.

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confidence: 99%

Rate, associated factors and outcomes of recurrence of Kawasaki disease in Ontario, Canada

Chahal

Somji

Manlhiot

et al. 2012

Pediatrics International

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“…The HLA-DR gene variations were not associated with the susceptibility of KD and CAAs in Taiwanese population (8). HLA-G plays a crucial role for the susceptibility to KD and CAA (17). MHC class II was not associated with the pathogenesis of KD (18).…”

Section: Resultsmentioning

confidence: 99%

Human lymphocyte antigen B‐associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm

Hsieh

Lin

Chang³

et al. 2010

Clinical Laboratory Analysis

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“…Recently, significant associations of single nucleotide polymorphisms (SNPs) within the HLA-G and HLA-E genes were reported (J.J. Kim et al, 2008;). However, most of the previous studies, including those describing negative association results, were conducted by analyzing a relatively small number of cases and controls, while replication studies with larger cohorts have not been performed yet.…”

Section: Human Leukocyte Antigen (Hla) Genesmentioning

confidence: 99%