Genetic variants in the MicroRNA biosynthetic pathway Gemin3 and Gemin4 are associated with a risk of cancer: a meta-analysis

Abstract

The effects of the microRNA (miRNA) processing genes Gemin3 and Gemin4 on cellular signaling pathways could have a major impact on the risk of cancer. Several studies concerning the association between the Gemin3 rs197412, Gemin4 rs7813 and Gemin4 rs2740348 polymorphisms with cancer susceptibility have been published. The present meta-analysis summarized this evidence and evaluated the precision of these relationships. Relevant studies (published prior to December 16th, 2015) without language restriction were identified using the PubMed, Web of Science and China National Knowledge Infrastructure (CNKI) on-line databases. The data were extracted from the eligible studies and were processed using Stata 12.0 software. Seven studies (2,588 cases and 2,549 controls) indicated that the rs7813 polymorphism was significantly associated with increased cancer risk (TT vs TC + CC, OR = 1.18 95% CI [1.05–1.32]). Six studies (1,314 cases and 1,244 controls) indicated that rs2740348 was associated with an increased cancer risk (GG vs. GC + CC, OR = 1.41 95% CI [1.00–1.83]). However the rs197412 polymorphism was not associated with an increased cancer risk (OR = 0.97 95% CI [0.80–1.19]). Our results suggest that the Gemin4 rs7813 T > C and rs2740348 G > C polymorphisms are associated with cancer susceptibility.

Association of <em>GEMIN4</em> gene polymorphism and the risk of cancer: a meta-analysis

“… 26 , 27 More interestingly, Yang et al found that a haplotype of the GEMIN4 gene including rs2740348 was associated with increased risk of bladder cancer. 31 In our present meta-analysis, we found that rs2740348 was significantly associated with increased risk of cancer in the general population under the recessive model (GG vs GC/CC), which agreed with the result reported by Zhu et al 35 However, this conclusion was only confirmed in a mixed population, but not in Asians and Caucasians. Therefore, the discrepancy of the results might be partly attributed to the difference of the study population.…”

“… 24 , 32 In the present study, we reported that rs7813 was related to an increased risk of cancer in the general population under the recessive model (TT vs TC/CC), but this conclusion was only confirmed in Asians, not in Caucasians, which is contrary to a previous meta-analysis. 35 Thus, we inferred that the discrepancy might be explained by the diversity of study population and tumor types.…”

“…Although a meta-analysis conducted by Zhu et al firstly showed that rs2740348 and rs7813 polymorphisms were associated with increased risk of cancer, the total number of subjects in their meta-analysis was also limited. 35 Compared with previous meta-analysis, one advantage of our meta-analysis is that it included larger sample size, nearly double that of studies earlier. In addition, another new finding of our study is that it firstly evaluates the association between the rs3744741 polymorphism and the risk of cancer.…”

Polymorphisms in GEMIN4 and AGO1 Genes Are Associated with the Risk of Lung Cancer: A Case-Control Study in Chinese Female Non-Smokers

“…The role of GEMIN4 protein in miRISC is not very clear. Aberrant microRNA biosynthesis genes have been found to be implicated in the genesis, development and survival of several types of cancer, indicating that a more general role may exist in microRNA biosynthesis genes in modifying the development of cancer [15,16,18,19,20,31,32]. While the underlying associations by which microRNA biosynthesis genes influences the risk of lung cancer remains unclear, our findings provide strong evidence regarding the association between SNPs in microRNA biosynthesis genes and lung cancer risk.…”

“…MicroRNAs have been confirmed to be involved in most of the human biological processes at the posttranscriptional level; deregulation of microRNA is considered to be involved in human cancer [7,8,9,10]. The abnormality of microRNA biosynthesis genes can affect the regulatory effect of global microRNAs to target mRNA, thereby influencing diseases; therefore, the abnormality of microRNA biosynthesis genes may play an important part in human cancer [11,12,13,14,15]. …”