Genetic variants in vitamin D pathway in Egyptian asthmatic children: A pilot study

Ismail, Magda M. F.; Elnady, Hala G.; Fouda, Eman

doi:10.1016/j.humimm.2013.08.284

Cited by 29 publications

(23 citation statements)

References 31 publications

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“…Literature data suggest higher frequency of FF compared to ff genotype which is in accordance with the results obtained in our study (FF:ff in BA vs. control-46.84%:7.59% vs. 69.66%:2.25%) [Minamitani et al, 1998]. Tizaoui et al [2014] showed that F allele and FF genotypes had protective effect on BA development in female patients and BA patients with low blood levels of 25-hydroxy vitamin D. In Tunisian and Egyptian populations, F allele was associated with 1.5-and 2.68-folds higher risk for BA, respectively [Ismail et al, 2013;Maalmi et al, 2013]. Moreover, the recessive model showed the protective effect of FF genotype indicating 2.6-folds lower risk for BA in the presence of this genotype.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Receptor Gene Polymorphisms in Serbian Patients With Bronchial Asthma: A Case‐Control Study

Despotović

Stoimenov²,

Stanković

et al. 2017

J of Cellular Biochemistry

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Vitamin D and single nucleotide polymorphisms (SNPs) in vitamin D receptor (VDR) gene are potentially involved in the pathogenesis of bronchial asthma (BA); however, precise mechanisms by which vitamin D reduces the inflammation and the role of VDR SNPs in BA are not completely understood. The aim of this study was to examine the possible associations of FokI, BsmI, ApaI, and TaqI SNPs with BA. A total of 168 subjects were screened for VDR SNPs using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. The obtained results showed statistically significant differences in the distribution of FokI genotypes (df = 2; P = 0.008) and alleles (P = 0.002; OR = 0.446; 95%CI = 0.264-0.752) between patients and controls. Distributions of BsmI, ApaI, and TaqI genotypes and alleles did not show statistical differences. BsmI, ApaI, and TaqI SNPs are in linkage disequilibrium (LD) in the whole studied group, as well as in BA patients and controls. The strongest LD was observed between BsmI and TaqI (r = 0.69 for all subjects in the study; r = 0.75 in BA; r = 0.64 in controls), while lower values of LD were observed for BsmI and ApaI, and ApaI and TaqI SNPs. This is the first study that examined the association of VDR SNPs (FokI, BsmI, ApaI, and TaqI) in Serbian patients with BA indicating protective effect of FF genotype and F allele of FokI SNP on BA development. J. Cell. Biochem. 118: 3986-3992, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Vitamin D Receptor Gene Polymorphisms in Serbian Patients With Bronchial Asthma: A Case‐Control Study

Despotović

Stoimenov²,

Stanković

et al. 2017

J of Cellular Biochemistry

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“…Specific VDBP-and VDR SNPs were significantly associated with pediatric asthma development in a case-control study among Egyptian children [111]. Other studies have associated non-VDR genetic variation to paediatric asthma [269], including 25hydroxyalse [199].…”

Section: Vitamin D Binding Protein (Vdbp)mentioning

confidence: 90%

Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms

Kerley

Elnazir

Faul

et al. 2015

Pulmonary Pharmacology & Therapeutics

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Vitamin D deficiency (VDD) is highly prevalent worldwide. The classical role for vitamin D is to regulate calcium absorption form the gastrointestinal tract and influence bone health. Recently vitamin D receptors and vitamin D metabolic enzymes have been discovered in numerous sites systemically supporting diverse extra-skeletal roles of vitamin D, for example in asthmatic disease. Further, VDD and asthma share several common risk factors including high latitude, winter season, industrialization, poor diet, obesity, and dark skin pigmentation. Vitamin D has been demonstrated to possess potent immunomodulatory effects, including effects on T cells and B cells as well as increasing production of antimicrobial peptides (e.g. cathelicidin). This immunomodulation may lead to asthma specific clinical benefits in terms of decreased bacterial/viral infections, altered airway smooth muscle-remodeling and -function as well as modulation of response to standard anti-asthma therapy (e.g. glucocorticoids and immunotherapy). Thus, vitamin D and its deficiency have a number of biological effects that are potentially important in altering the course of disease pathogenesis and severity in asthma. The purpose of this first of a two-part review is to review potential mechanisms whereby altering vitamin D status may influence asthmatic disease.

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“…Vitamin D deficiencies have been associated with high IgE levels in some populations but not all (1–3, 5, 26). Polymorphisms in the VDR gene, as well as in several vitamin D metabolizing genes, have been identified and linked to asthma susceptibility (27, 28). These genetic polymorphisms in the VDR gene and other vitamin D-associated genes are genetic factors that may control how the host utilizes and/or responds to changes in vitamin D from the environment and the effects on serum IgE.…”

Section: Discussionmentioning

confidence: 99%

Control of Circulating IgE by the Vitamin D Receptor In Vivo Involves B Cell Intrinsic and Extrinsic Mechanisms

James

Weaver

Cantorna

2017

The Journal of Immunology

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Vitamin D deficiency is associated with the development of asthma and allergy. The active form of vitamin D (1,25(OH)2D) regulates B cells in vitro and mice without the vitamin D receptor (VDR KO) have high serum IgE. Whole body VDR KO, T-VDR KO, B-VDR KO and vitamin D deficient mice were used to determine the targets of vitamin D in the regulation of IgE in vivo. Vitamin D deficient, VDR KO and B-VDR KO mice developed hyper-IgE, while T-VDR KO mice did not. The data show that IL-10 secretion by B cells and CD1d expression on B10 cells was lower in VDR KO mice. Mesenteric lymph node cultures from VDR KO and B-VDR KO mice secreted higher IgE ex vivo than WT cultures, and the addition of IL-10 eliminated the difference in IgE production between VDR KO and WT cultures. The increase in IgE in VDR KO mice was 2-fold greater than in the B-VDR KO mice suggesting that VDR deficiency in non-B cells contributes to hyper-IgE in vivo. Antibiotic depletion of the microbiota raised serum IgE 4-fold in both WT and VDR KO mice. The VDR directly and indirectly regulates IgE production in B cells. Vitamin D, through the VDR, is an environmental factor that helps to maintain low serum IgE responses.

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Genetic variants in vitamin D pathway in Egyptian asthmatic children: A pilot study

Cited by 29 publications

References 31 publications

Vitamin D Receptor Gene Polymorphisms in Serbian Patients With Bronchial Asthma: A Case‐Control Study

Vitamin D Receptor Gene Polymorphisms in Serbian Patients With Bronchial Asthma: A Case‐Control Study

Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms

Control of Circulating IgE by the Vitamin D Receptor In Vivo Involves B Cell Intrinsic and Extrinsic Mechanisms

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