Genetic variants of chromosome 9p21.3 region associated with coronary artery disease and premature coronary artery disease in an Asian Indian population

Bellary, Kalpana; Murthy, Dwarkanath K.; Balakrishna, Nagalla; Aiyengar, Mohini T.

doi:10.1016/j.ihj.2019.04.005

Cited by 8 publications

(5 citation statements)

References 41 publications

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“…The information was drawn out from 18,430 CHD cases and 22,549 controls (Table 1 ). 9 , 10 , 11 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 Of the 35 obtained literatures after the preliminary search course, 17 met the present meta‐analysis including criteria. Among the eighteen eliminated papers, five of them were of review character.…”

Section: Resultsmentioning

confidence: 99%

CDKN2B‐AS1 gene rs4977574 A/G polymorphism and coronary heart disease: A meta‐analysis of 40,979 subjects

Wang

Zhang

2021

J Cellular Molecular Medi

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Section: Resultsmentioning

confidence: 99%

CDKN2B‐AS1 gene rs4977574 A/G polymorphism and coronary heart disease: A meta‐analysis of 40,979 subjects

Wang

Zhang

2021

J Cellular Molecular Medi

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“…The study from Dandona et al [ 24 ] reported that subjects with rs1333049 risk genotype had three-vessel disease more frequently than the one-vessel disease; disease severity was directly associated with the number of risk alleles the subject was carrying. Wang et al associated CC genotype with coronary plaque progression [ 25 ] and later to early-onset and increased severity of coronary artery disease [ 26 ] in a Chinese population; similar conclusions were made on Tunisian T2DM population [ 27 ], Asian-Indian [ 28 ], and Caucasian [ 29 ] populations.…”

Section: Discussionmentioning

confidence: 61%

Association of Myocardial Infarction with CDKN2B Antisense RNA 1 (CDKN2B-AS1) rs1333049 Polymorphism in Slovenian Subjects with Type 2 Diabetes Mellitus

Tibaut

Naji

Petrovič

2022

Genes

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Background: We examined the role of rs1333049 polymorphism of the CDKN2B Antisense RNA 1 (CDKN2B-AS1) on the prevalence of myocardial infarction (MI) in Slovenian subjects with type 2 diabetes mellitus (T2DM). Methods: A total of 1071 subjects with T2DM were enrolled in this retrospective cross-sectional case-control study. Of the subjects, 334 had a history of recent MI, and 737 subjects in the control group had no clinical signs of coronary artery disease (CAD). With logistic regression, we performed a genetic analysis of rs1333049 polymorphism in all subjects. Results: The C allele of rs1333049 polymorphism was statistically more frequent in MI subjects (p = 0.05). Subjects with CC genotype had a higher prevalence of MI than the control group in the co-dominant (AOR 1.50, CI 1.02–2.21, p = 0.04) and recessive (AOR 1.38, CI 1.09–1.89, p = 0.04) genetic model. Conclusions: According to our study, the C allele and CC genotype of rs1333049 polymorphism of CDKN2B-AS1 are possible markers of MI in T2DM subjects in the Slovenian population.

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“…46 Consistently, it has been reported that the T allele at rs1333045 is statistically associated with increased susceptibility to coronary artery disease (p < 0.0001), T2DM (p = 0.048), and myocardial infarction (p = 1.15E−08). [47][48][49] Noteworthy in silico analysis showed that lncRNA CDKN2B rs1333045T>C causes to gain microRNA target sites for seven microRNAs and probably has the strongest and weakest binding to hsa-miR-5006-5p and hsa-miR-5582-5p, respectively. of hsa-miR-5582-5p was lower in tumor tissues compared to adjacent normal tissues in colorectal cancer patients, while the expression of the target proteins showed opposite patterns.…”

Section: Discussionmentioning

confidence: 99%

“… 46 Consistently, it has been reported that the T allele at rs1333045 is statistically associated with increased susceptibility to coronary artery disease ( p < 0.0001), T2DM ( p = 0.048), and myocardial infarction ( p = 1.15E−08). 47 , 48 , 49 Noteworthy in silico analysis showed that lncRNA CDKN2B rs1333045T>C causes to gain microRNA target sites for seven microRNAs and probably has the strongest and weakest binding to hsa‐miR‐5006‐5p and hsa‐miR‐5582‐5p , respectively. Interestingly, Hyun‐Ju An et al.…”

Section: Discussionmentioning

confidence: 99%

Genetic variations in IKZF3, LET7‐a2, and CDKN2B‐AS1: Exploring associations with metabolic syndrome susceptibility and clinical manifestations

Paniri,

Hosseini,

Fattahi

et al. 2024

Clinical Laboratory Analysis

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Background and aimMetabolic syndrome (MetS) increases the risk of atherosclerosis and diabetes, but there are no approved predictive markers. This study assessed the role of specific genetic variations in MetS susceptibility and their impact on clinical manifestations.MethodIn this study, a genotype–phenotype assessment was performed for IKZF3 (rs907091), microRNA‐let‐7a‐2 (rs1143770), and lncRNA‐CDKN2B‐AS1 (rs1333045).ResultsAnalyses indicate that while rs907091 and rs1143770 may have potential associations with MetS susceptibility and an increased risk of atherosclerosis and diabetes, there is an observed trend suggesting that the rs1333045 CC genotype may be associated with a decreased risk of MetS. The genotypes and allele frequencies of rs1333045 were significantly different between studied groups (OR = 0.56, 95% CI 0.38–0.81, p = 0.002, and OR = 0.71, 95% CI 0.55–0.92, p = 0.008), with the CC genotype displaying increased levels of HDL. Furthermore, the rs907091 TT genotype was associated with increased triglyceride, cholesterol, and HOMA index in MetS patients. Subjects with the CC genotype for rs1143770 had higher HbA1c and BMI. In silico analyses illustrated that rs907091 C remarkably influences the secondary structure and the target site of a broad spectrum of microRNAs, especially hsa‐miR‐4497. Moreover, rs1333045 creates a binding site for seven different microRNAs.ConclusionFurther studies on other populations may help confirm these SNPs as useful predictive markers in assessing the MetS risk.

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Genetic variants of chromosome 9p21.3 region associated with coronary artery disease and premature coronary artery disease in an Asian Indian population

Cited by 8 publications

References 41 publications

CDKN2B‐AS1 gene rs4977574 A/G polymorphism and coronary heart disease: A meta‐analysis of 40,979 subjects

CDKN2B‐AS1 gene rs4977574 A/G polymorphism and coronary heart disease: A meta‐analysis of 40,979 subjects

Association of Myocardial Infarction with CDKN2B Antisense RNA 1 (CDKN2B-AS1) rs1333049 Polymorphism in Slovenian Subjects with Type 2 Diabetes Mellitus

Genetic variations in IKZF3, LET7‐a2, and CDKN2B‐AS1: Exploring associations with metabolic syndrome susceptibility and clinical manifestations

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