Genetic Variants Of Cytochrome b-245, Alpha Polypeptide Gene And Premature Acute Myocardial Infarction Risk In An Iranian Population

Amin, Faisal Mohammad; Jahani, Mohammad; Ghaedi, Hamid; Alipoor, Behnam; Fatemi, Ahmad; Tajik, Michael; Sharifi, Zohreh; Golmohammadi, Taghi; Azarnejad, Asaad; Alipoor, Sadegh; Valipour, Aliasghar; Mousavizadeh, Kazem

doi:10.2478/jomb-2014-0066

Cited by 3 publications

(3 citation statements)

References 28 publications

(34 reference statements)

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“…VEGF-A influences vascular proliferation and permeability, allowing the body to compensate for hypoxia and speed up inflammatory processes [ 60 ]. Cytochrome b-245 beta chain gene is part of cytochrome b-245, which is essential for microbicidal oxidase development in phagocytic cells that plays critical roles in the pathogenesis of coronary artery disease [ 61 ]; it is also associated with ventricular hypertrophy and arrhythmia [ 62 ]. Prostaglandin-endoperoxide synthase (PTGS) is the key enzyme in prostaglandin biosynthesis, and the adverse effects of PTGS inhibitors on the cardiovascular system have been identified [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics and System Biological Approaches for the Identification of Genetic Risk Factors in the Progression of Cardiovascular Disease

Barua

Omit

Rana

et al. 2022

Cardiovascular Therapeutics

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Background. Cardiovascular disease (CVD) is the combination of coronary heart disease, myocardial infarction, rheumatic heart disease, and peripheral vascular disease of the heart and blood vessels. It is one of the leading deadly diseases that causes one-third of the deaths yearly in the globe. Additionally, the risk factors associated with it make the situation more complex for cardiovascular patients, which lead them towards mortality, but the genetic association between CVD and its risk factors is not clearly explored in the global literature. We addressed this issue and explored the linkage between CVD and its risk factors. Methods. We developed an analytical approach to reveal the risk factors and their linkages with CVD. We used GEO microarray datasets for the CVD and other risk factors in this study. We performed several analyses including gene expression analysis, diseasome analysis, protein-protein interaction (PPI) analysis, and pathway analysis for discovering the relationship between CVD and its risk factors. We also examined the validation of our study using gold benchmark databases OMIM, dbGAP, and DisGeNET. Results. We observed that the number of 32, 17, 53, 70, and 89 differentially expressed genes (DEGs) is overlapped between CVD and its risk factors of hypertension (HTN), type 2 diabetes (T2D), hypercholesterolemia (HCL), obesity, and aging, respectively. We identified 10 major hub proteins (FPR2, TNF, CXCL8, CXCL1, IL1B, VEGFA, CYBB, PTGS2, ITGAX, and CCR5), 12 significant functional pathways, and 11 gene ontological pathways that are associated with CVD. We also found the connection of CVD with its risk factors in the gold benchmark databases. Our experimental outcomes indicate a strong association of CVD with its risk factors of HTN, T2D, HCL, obesity, and aging. Conclusions. Our computational approach explored the genetic association of CVD with its risk factors by identifying the significant DEGs, hub proteins, and signaling and ontological pathways. The outcomes of this study may be further used in the lab-based analysis for developing the effective treatment strategies of CVD.

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Section: Discussionmentioning

confidence: 99%

Bioinformatics and System Biological Approaches for the Identification of Genetic Risk Factors in the Progression of Cardiovascular Disease

Barua

Omit

Rana

et al. 2022

Cardiovascular Therapeutics

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“…Also, the complexity of genetic and environmental factors could be involved [ 7 ]. It is believed that, similar to other vascular complications, genetic variants play a key role in IS susceptibility [ 8 , 9 , 10 ].…”

Section: Intoductionmentioning

confidence: 99%

Common Variations in Prothrombotic Genes and Susceptibility to Ischemic Stroke in Young Patients: A Case-Control Study in Southeast Iran

et al. 2019

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Background and Objective: Evidence indicates that genetic factors may be involved in the risk of ischemic stroke (IS). The aim of this study was to assess the effect of genetic polymorphisms located in exons or untranslated regions of MTHFR as well as FV genes on ischemic stroke. Materials and Methods: In this case-control study, 106 patients with IS and 157 healthy volunteers (age <50 years) were genotyped for MTHFR C677T, A1298C, C2572A and C4869G, FVL, and prothrombin G20210A polymorphisms. Results: The MTHFR 677CT genotype was more frequent in patients and increased risk of IS with Odds Ratio = 1.9. The MTHFR A1298C and C2572A polymorphisms were not associated with IS in dominant and recessive models. Our findings showed a significant decrease in the MTHFR 4869CG genotype in IS patients, and this variant was associated with a decreased risk of IS in the dominant model. The CAAT haplotype was associated with increased risk, and the GAAC haplotype was associated with decreased risk of IS compared to other haplotypes. There was no relation between FVL G1691A polymorphism and IS risk. Conclusions: The present study showed that the MTHFR 677CT genotype was more frequent and the MTHFR 4869CG genotype was less frequent in young IS patients.

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“…Coronary artery disease (CAD) is the most common cause of mortality and disability from incommunicable disease across the globe (1, 2, 3). The prevalence of CAD in the United States was one of every six deaths in 2010 (4) and it is estimated to be a factor in nearly 50% of all deaths each year in Iran (5).…”

Section: Introductionmentioning

confidence: 99%

Association of miR-149 (RS2292832) Variant with the Risk of Coronary Artery Disease

Ghaffarzadeh¹,

Ghaedi²,

Alipoor³

et al. 2017

Journal of Medical Biochemistry

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SummaryBackground:Coronary artery disease (CAD) is the most common cause of mortality and disability from incommunicable disease in the world. Although the association between the single nucleotide polymorphisms (SNPs) in protein-coding genes and the risk of CAD has been investigated extensively, very few heart-disease associated studies concerning the SNPs in miRNA genes have been reported. The present study was performed to elucidate the association between the pre-microRNA-149 (miR-149) SNP rs2292832 and the risk of CAD in an Iranian population.Methods:Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were performed to identify the genotypes of the miR-149 SNP rs2292832 in 421 unrelated subjects (272 with CAD and 149 controls).Results:Our analysis revealed that the TT genotype was more frequent in CAD patients than control subjects (P=0.02) implying that TT genotype should be considered as a risk factor in CAD development (TT vs. TC+CC p=0.02, OR=1.88).Conclusions:The present study suggests that rs2292832-TT in pre-miR-149 is associated with CAD in an Iranian population.

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Genetic Variants Of Cytochrome b-245, Alpha Polypeptide Gene And Premature Acute Myocardial Infarction Risk In An Iranian Population

Cited by 3 publications

References 28 publications

Bioinformatics and System Biological Approaches for the Identification of Genetic Risk Factors in the Progression of Cardiovascular Disease

Bioinformatics and System Biological Approaches for the Identification of Genetic Risk Factors in the Progression of Cardiovascular Disease

Common Variations in Prothrombotic Genes and Susceptibility to Ischemic Stroke in Young Patients: A Case-Control Study in Southeast Iran

Association of miR-149 (RS2292832) Variant with the Risk of Coronary Artery Disease

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