Genetic variants of H2AX gene were associated with P M 2.5 -modulated DNA damage levels in Chinese Han populations

Sun, Chongqi; Chu, Minjie; Chen, Weihong; Jin, Guangfu; Gong, Jianhang; Zhu, Meng; Yuan, Jing; Dai, Juncheng; Wang, Meilin; Pan, Yun; Song, Yuanchao; Ding, Xiaojie; Du, Mulong; Dong, Jing; Zhang, Zhengdong; Hu, Zhibin; Wu, Tangchun; Shen, Hongbing

doi:10.1016/j.mrfmmm.2015.05.007

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…Especially, this variant is located in the promoter of H2AX and therefore, may be linked with a functional change in the protein product by altering the efficiency of gene expression 47 . In line with the importance of our results, previously published data by Sun et al have shown that the G allele of H2AX ‐rs7759 is associated with DNA damage levels in individuals exposed to particulate matter 2.5 (PM2.5) 48 . Moreover, previous studies have indicated that the G allele of H2AX ‐rs7759 is related to an increased risk of breast cancer 49 .…”

Section: Discussionsupporting

confidence: 83%

“… 47 In line with the importance of our results, previously published data by Sun et al have shown that the G allele of H2AX ‐rs7759 is associated with DNA damage levels in individuals exposed to particulate matter 2.5 (PM2.5). 48 Moreover, previous studies have indicated that the G allele of H2AX ‐rs7759 is related to an increased risk of breast cancer. 49 Accordingly, our observations supportively suggest that the H2AX ‐rs7759 polymorphism and its G allele‐related genotypes could be one of the key genetic targets in influencing the effects of BTEX chemicals and increase the susceptibility of individuals exposed to the BTEX harmful effects, especially abnormalities in lymphocytes and granulocytes, through altering the mutation repair capacity.…”

Section: Discussionmentioning

confidence: 99%

“…Sun et al have shown that the G allele of H2AX-rs7759 is associated with DNA damage levels in individuals exposed to particulate matter 2.5 (PM2.5) 48. Moreover, previous studies have indicated that the G allele of H2AX-rs7759 is related to an increased risk of breast cancer 49.…”

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confidence: 99%

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Genetic variations in ATM and H2AX loci contribute to risk of hematological abnormalities in individuals exposed to BTEX chemicals

Roshan

Mansoori

Hosseini

et al. 2022

Clinical Laboratory Analysis

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Background: Loci controlling DNA double-strand breaks (DSBs) repair play an important role in defending against the harmful health effects of benzene, toluene, ethylbenzene, and xylene (BTEX), but their gene variants may alter their repair capacity. The aim of the current study was to determine the relationship of functional polymorphisms ATM-rs228589 A>T, WRN-rs1800392 G>T and H2AX-rs7759 A>G in DBS repair loci with the abnormal hematological indices in workers who exposed to BTEXs. Methods:We included 141 cases with one or more abnormal hematological parameters, who had been occupationally exposed to BTEX chemicals and 152 controls with a similar exposure condition but without any abnormal hematological parameters. Atmospheric concentrations of BTEXs were measured and whole blood samples were taken from the participants to determine hematologic parameters and SNP genotyping.Results: Results showed that T allele of ATM-rs228589 and G allele of H2AX-rs7759 had a higher frequency in cases than controls (p = 0.012 and p = 0.001, respectively). Also, AT and TT genotypes of ATM-rs228589 and AG and GG genotypes of H2AX-rs7759 were higher in cases compared to controls. The AT and TT genotypes of ATM-rs228589 have significant associations with a risk of hematological abnormalities in the codominant (AT vs. AA, p = 0.018), dominant (AT + TT vs. AA, p = 0.010) and overdominant (AT vs. AA + TT, p = 0.037) models. The GG and AG genotypes of H2AX-rs7759 were in relation with increased risk of abnormal hematological indices under codominant (GA vs. AA, p = 0.009 & GG vs. AA, p = 0.005), dominant (AG + GG vs. AA, p = 0.001), and recessive (GG vs. AA + AG, p = 0.025) models.Conclusions: These observations may help to understand the mechanisms of BTEX hematotoxicity and identify useful biomarkers of risk assessment for workers exposed to BTEX.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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Genetic variations in ATM and H2AX loci contribute to risk of hematological abnormalities in individuals exposed to BTEX chemicals

Roshan

Mansoori

Hosseini

et al. 2022

Clinical Laboratory Analysis

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Ambient Air Pollution and Biomarkers of Health Effect

Yang

Deng

et al. 2017

Advances in Experimental Medicine and Biology

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Recently, the air pollution situation of our country is very serious along with the development of urbanization and industrialization. Studies indicate that the exposure of air pollution can cause a rise of incidence and mortality of many diseases, such as chronic obstructive pulmonary disease (COPD), asthma, myocardial infarction, and so on. However, there is now growing evidence showing that significant air pollution exposures are associated with early biomarkers in various systems of the body. In order to better prevent and control the damage effect of air pollution, this article summarizes comprehensively epidemiological studies about the bad effects on the biomarkers of respiratory system, cardiovascular system, and genetic and epigenetic system exposure to ambient air pollution.

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Particulate matter 2.5 accelerates aging: Exploring cellular senescence and age-related diseases

Wang,

Shi,

Lin

et al. 2024

Ecotoxicology and Environmental Safety

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Genetic variants of H2AX gene were associated with P M 2.5 -modulated DNA damage levels in Chinese Han populations

Cited by 6 publications

References 31 publications

Genetic variations in ATM and H2AX loci contribute to risk of hematological abnormalities in individuals exposed to BTEX chemicals

Genetic variations in ATM and H2AX loci contribute to risk of hematological abnormalities in individuals exposed to BTEX chemicals

Ambient Air Pollution and Biomarkers of Health Effect

Particulate matter 2.5 accelerates aging: Exploring cellular senescence and age-related diseases

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