Genetic variants of TCF7L2 gene and its coherence with metabolic parameters in Lithuanian (Kaunas district) women population with previously diagnosed gestational diabetes mellitus compared to general population

Abstract

To determine the association of genetic variants rs7901695, rs7903146, rs7895340, rs11196205, rs12255372 of transcription factor 7 like 2 (TCF7L2) gene and its coherence with metabolic parameters in Lithuanian (Kaunas district) women population with previously diagnosed gestational diabetes mellitus (GDM) and to compare the prevalence of TCF7L2 single nucleotide polymorphism (SNP) results to general population. Methods: Women with previously diagnosed GDM participated in the study. Anthropometric measurements were taken. Carbohydrate and fat metabolism were evaluated. TCF7L2 SNP common variants (rs7901695, rs7903146, rs7895340, rs11196205, rs12255372) were set. The prevalence of TCF7L2 the same SNP alleles were also evaluated for women of the general population. The results were compared to the main study group (women with previously diagnosed GDM). The results were calculated in a ratio of 1:2. General population group comprised 300 women who were selected from the random sample of the Kaunas city population. Statistical analysis was made with the statistical package IBM SPSS Statistics version 21. Quantitative parametric variables presented as mean and standard deviation, qualitative variables-as absolute numbers and percentage. ANOVA test was used, for the comparison between three or more groups. Quantitative variables were compared using Student's ttest. Categorical variables were compared using chi-square test. Correlation analysis of parametrical data was performed by Pearson's correlation. Odds ratios (OR) with 95% CIs were presented. The results were considered statistically significant at p < 0.05. Results: 158 women with previously (15-47 years ago) diagnosed GDM participated in the study. The mean age of participants was 53.0 ± 8.2 years and 60.2 ± 7.5 years (p < 0.001), BMI-31.4 ± 7.9 kg/m 2 and 29.9 ± 5.8 kg/m 2 (p < 0.001) in GDM group and general population

Saudi Community-Based Screening Study on Genetic Variants in β-Cell Dysfunction and Its Role in Women with Gestational Diabetes Mellitus

“…This study found that the minor allele frequency (MAF) of rs7903146 was 41%, whereas other studies have shown inconsistent results across countries and regions. For example, the frequency of this allele is 10.5% in Malaysia [ 45 ], 3.3% in South Korea [ 46 ], 2% in China [ 29 ], 36.4% in Qatar [ 47 ], 33% in Poland [ 25 ], 36.2% in Spain [ 48 ], 74% in Lithuania [ 49 ], 38.8% in India, 24% in Bangladesh [ 50 ], 23% in Mexico [ 27 ], 48.4% in Australia [ 51 ], and 27.6% in Denmark [ 52 ]. The MAF of the rs2237892 SNP in this population was determined to be 9%, with a prevalence of 8.3% in Poland [ 35 ], which is quite close to our study.…”