Genetic variants of tumor necrosis factor-α -308G/A (rs1800629) but not Toll-interacting proteins or vitamin D receptor genes enhances susceptibility and severity of malaria infection

Ojurongbe, Olusola; Funwei, Roland I.; Snyder, Tara; Farid, Iman; Aziz, Najihah; Li, Yang; Falade, Catherine O.; Thomas, Bolaji N.

doi:10.1007/s00251-017-1032-4

Cited by 12 publications

(5 citation statements)

References 29 publications

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“…VDR up-regulation has been related to the intestinal damage occurring during Plasmodium chabaudi infection, suggesting that it could depend on VDR-mediated NF-kB activation [104]. Finally, a very recent study has assayed 109 patients affected by malaria for VDR single nucleotide polymorphism (SNP rs 731236), finding no association between SNP rs 731236 and both infection susceptibility and disease severity [105].…”

Section: Studies On Humansmentioning

confidence: 99%

Vitamin D in malaria: more hypotheses than clues

Bivona

Agnello

Sasso

et al. 2019

Heliyon

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Vitamin D is a secosteroid hormone regulating calcium and phosphate metabolism, immune response and brain development. Low blood 25(OH)D levels have been reported in patients affected by infectious diseases caused by parasites, including malaria. Despite the high effectiveness of antimalarials, malaria is burdened with high morbidity and mortality, and the search for additional therapies is rapidly growing. Furthermore, available preventive measures have proved to be barely effective so far. Finding new prevention and therapy tools is a matter of urgency. Studies on animal models and humans have hypothesized some mechanisms by which the hormone can influence malaria pathogenesis, and the role of Vitamin D supplementation in preventing and treating this disease has been suggested. Few studies on the association between Vitamin D and malaria are available and disagreeing results have been reported. Studies in humans reporting an association between low 25(OH)D circulating levels and Malaria have a small sample size and observational study-set. Randomized controlled trials are needed in order to understand if Vitamin D administration might play a role in preventing and treating malaria.

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Section: Studies On Humansmentioning

confidence: 99%

Vitamin D in malaria: more hypotheses than clues

Bivona

Agnello

Sasso

et al. 2019

Heliyon

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“…TNF-α (G-308A) mutants have been associated with susceptibility to P . falciparum infection 23 , higher levels of parasitaemia 22 and severe malaria 25 . However, an independent study on South-West Nigerian infected patients failed to demonstrate such association 24 .…”

Section: Introductionmentioning

confidence: 99%

TNF-α promoter polymorphisms (G-238A and G-308A) are associated with susceptibility to Systemic Lupus Erythematosus (SLE) and P. falciparum malaria: a study in malaria endemic area

Mahto

Tripathy

Meher

et al. 2019

Sci Rep

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Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine associated with autoimmune and infectious diseases. Importance of TNF-α in P . falciparum malaria and systemic lupus erythematosus (SLE) have been demonstrated. However, association of functional promoter variants with SLE and malaria is lacking in malaria endemic population. A total of 204 female SLE patients and 224 age and sex matched healthy controls were enrolled in the study. Three hundred fourteen P . falciparum infected patients with different clinical phenotypes were included. TNF-α polymorphisms (G-238A & G-308A) were genotyped by PCR-RFLP. Plasma levels of TNF-α was quantified by ELISA. Heterozygous mutants and minor alleles of TNF-α (G-238A and G-308A) polymorphisms were significantly higher in SLE patients compared to healthy controls and associated with development of lupus nephritis. In addition, both promoter variants were associated with severe P . falciparum malaria. SLE patients demonstrated higher levels of plasma TNF-α compared to healthy controls. TNF-α (G-238A and G-308A) variants were associated with higher plasma TNF-α. In conclusion, TNF-α (G-238A & G-308A) variants are associated with higher plasma TNF-α levels in SLE patients residing in malaria endemic areas and could be a contributing factor in the development of SLE and susceptibility to severe P . falciparum malaria.

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“…TRAF2 is a key element of TNF [46,47], which has significant roles in inflammation. However, as also for CEBPD, SRC, and TP53, TNF has established links to cancer and its polymorphisms serving as susceptibility factor for many infectious diseases [48]. CEBPD is a tumor suppressor [49,50], which identifies it as a bad candidate for repression.…”

Section: Discussionmentioning

confidence: 99%

Dissecting Transcription Factor-Target Interaction in Bovine Coronavirus Infection

et al. 2020

Self Cite

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Coronaviruses are RNA viruses that cause significant disease within many species, including cattle. Bovine coronavirus (BCoV) infects cattle and wild ruminants, both as a respiratory and enteric pathogen, and possesses a significant economic threat to the cattle industry. Transcription factors are proteins that activate or inhibit transcription through DNA binding and have become new targets for disease therapies. This study utilized in silico tools to identify potential transcription factors that can serve as biomarkers for regulation of BCoV pathogenesis in cattle, both for testing and treatment. A total of 11 genes were identified as significantly expressed during BCoV infection through literature searches and functional analyses. Eleven transcription factors were predicted to target those genes (AREB6, YY1, LMO2, C-Rel, NKX2-5, E47, RORAlpha1, HLF, E4BP4, ARNT, CREB). Function, network, and phylogenetic analyses established the significance of many transcription factors within the immune response. This study establishes new information on the transcription factors and genes related to host-pathogen interactome in BCoV infection, particularly transcription factors YY1, AREB6, LMO2, and NKX2, which appear to have strong potential as diagnostic markers, and YY1 as a potential target for drug therapies.

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Genetic variants of tumor necrosis factor-α -308G/A (rs1800629) but not Toll-interacting proteins or vitamin D receptor genes enhances susceptibility and severity of malaria infection

Cited by 12 publications

References 29 publications

Vitamin D in malaria: more hypotheses than clues

Vitamin D in malaria: more hypotheses than clues

TNF-α promoter polymorphisms (G-238A and G-308A) are associated with susceptibility to Systemic Lupus Erythematosus (SLE) and P. falciparum malaria: a study in malaria endemic area

Dissecting Transcription Factor-Target Interaction in Bovine Coronavirus Infection

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