Genetic Variants within Endothelial Nitric Oxide Synthase Gene and Prostate Cancer: A Meta-Analysis

Abstract

Several variants within gene-encoding endothelial isoform of nitric oxide synthase have been reported to confer prostate cancer (PCa) susceptibility and/or progression. Nevertheless, studies referring to this issue have yielded inconsistent results. In order to elucidate the involvement of these variants in prostate carcinogenesis, we have conducted a meta-analysis of previously published case-control and relevant case-only studies. Eleven studies comprising in total 3,806 cases and 4,466 controls were included in the meta-analysis which yielded evidence of association of rs2070744 (OR CC = 1.43, 95% CI 1.04-1.97; p = 0.03) and intron 4a/b variant (OR ab+aa = 1.47, 95% CI 1.00-2.14; p = 0.05) with PCa risk under recessive and dominant model, respectively. Furthermore, PCa patients carrying 4a/b a allele were found to have an increased risk of cancer progression to a less differentiated form, characterized by a high Gleason score (OR = 2.29, 95% CI 1.51-3.49; p < 0.01) and to higher TNM stage (OR = 2.55, 95% CI 1.71-3.81; p < 0.01). These results support the involvement of NOS3 variants in molecular pathogenesis of PCa. Clin Trans Sci 2015; Volume 8: 23-31

Impact of RNA‑binding motif 3 expression on the whole transcriptome of prostate cancer cells: An RNA sequencing study

“…In addition to metabolism and the PLA2 family, several other signaling pathways and gene families were found to be closely associated with RBM3 regulation in the present study; for example, GNG5 and the G protein pathway (26), EDN1 and the angiogenesis pathway (27), NOS3 and the NO synthesis pathway (28), CD38 and the signal transduction pathway (29), and CYP2B6 and the response to drug pathway (30). These pathways have all been reported to be important for cancer development.…”

Nitric Oxide Synthase in Male Urological and Andrologic Functions

“…A meta-analysis conducted by Zhao et al suggested that eNOS gene 894G > T polymorphism contributed to aggravate the onset of prostate carcinoma in males [122]. Nikolic et al [123] also corroborated the involvement of eNOS or NOS3 gene in the pathogenesis of prostate carcinoma. NOS3 rs1799983 polymorphism augmented the risk of prostate carcinoma in various populations.…”

Endothelial Nitric Oxide Synthase Gene Polymorphism. Part 2. Polymorphic Variants T786c, 4a/B

“…Ме-та-анализ, посвященный выявлению участия по-лиморфизма 4а/b в развитии рака простаты, пока-зал наличие высокой положительной связи меж-ду данным заболеванием и вариантом 4а4а+4а4b (ОШ=1,47, 95% ДИ=1,00-2,14, р=0,05), также установлено, что носители аллеля «а» имеют повышенный риск прогрессирования рака [27]. Повышенная предрасположенность к развитию рака предстательной железы и полиморфизма 4а/b (4а4b в сравнении с 4b4b, ОШ=1,338; 95% ДИ=1.013-1.768; 4а4а + 4а4b в сравнении с 4b4b: ОШ=1,474, 95% ДИ=1.002-2,170) показана в ра-боте [28].…”