Genetic variation and population structure of Fasciola hepatica: an in silico analysis

Alvi, Mughees Aizaz; Khalid, Adeel; Ali, Rana Muhammad Athar; Saqib, Muhammad; Qamar, Warda; Li, Li; Ahmad, Bilal; Fu, Bao‐Quan; Yan, Hong‐Bin; Jia, Wan‐Zhong

doi:10.1007/s00436-023-07917-0

Cited by 8 publications

(2 citation statements)

References 49 publications

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“…Infectious diseases, especially parasitic infestations, are major public health concerns in both animals and humans (Alvi et al 2023a;Alvi et al 2023b). Schistosomiasis is considered a neglected tropical disease instigated by flatworms of the genus Schistosoma, remnants a major problem in several parts of the world.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Diagnosis of Schistosomiasis

2023

IJAB

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Schistosomiasis is considered a neglected tropical disease instigated by flatworms of the genus Schistosoma, remnants a major problem in several parts of the world. A timely and accurate diagnosis is indispensable for disease management and control. Significant advances in the identification of schistosomiasis have been made in current years, improving our ability to detect and characterize infections. This chapter focuses on recent advances in schistosomiasis diagnosis, with an emphasis on new methods and approaches. Molecular diagnostic techniques, such as polymerase chain reaction (PCR), and loop-mediated isothermal amplification (LAMP), have exhibited the ability to improve schistosomiasis findings, sensitivity, and specificity. These techniques identify Schistosoma DNA in biological specimens such as blood, urine, and stool, allowing for early detection and monitoring of infections. Furthermore, the development of multiplex PCR assays allows for the finding of multiple Schistosoma species at the same time, which aids in species-specific diagnosis and epidemiological studies. In addition to molecular approaches, serological test-based antibody detection has advanced significantly. When compared to traditional methods, novel serological assays utilizing recombinant antigens and antigen-detection methods have demonstrated improved diagnostic accuracy, offering increased sensitivity and specificity. These tests not only detect current infections but also provide information about previous exposure to Schistosoma parasites. These non-invasive methods enable assisting in treatment decisions and assessing treatment efficacy. Finally, recent advances in schistosomiasis diagnosis have greatly expanded our diagnostic capabilities, allowing for more accurate and efficient infection detection. Molecular diagnostics, serological assays, and imaging modalities have all contributed to a better understanding of the disease and better patient care. Continuous research and innovation in diagnostic methods are required to improve global schistosomiasis control and elimination efforts.

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Section: Introductionmentioning

confidence: 99%

Recent Advances in the Diagnosis of Schistosomiasis

2023

IJAB

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“…An emerging zoonosis is one that has recently been identified or evolved in recent past and still prevailing more in terms of its geographic, host, or vector ranges (Alvi et al 2023a). Over the past 70 years, about 250 zoonoses have been reported as emerging and re-emerging spreading over the globe with more intensity than previous (de Thoisy et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Factors Influencing the Emergence and Re-emergence of Zoonotic Infectious Diseases in Livestock and Human Populations

2023

IJAB

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The emergence of zoonotic infectious diseases poses a significant threat to human and animal health. Understanding the factors influencing the emergence of these diseases is crucial for effective prevention and control strategies. Livestock populations act as reservoirs for zoonotic pathogens, circulating silently and potentially infecting humans. Disease transmission, pathogenesis, and genetic diversity within and across the livestock and human populations play a significant role in disease susceptibility, thus increasing the risk of disease emergence. These factors also hinder disease surveillance, control measures, and timely interventions, allowing disease to spread among different geographical regions. The deviations in human and animal behavior, habitat, ecology, vector biology, pathogen adaptability, use of antibiotics, livestock farming, production systems, food safety, malnutrition, urbanization, deforestation, and climate contribute to the emergence of highly infectious diseases. In addition, wildlife animals also serve as a reservoir of zoonotic pathogens which cause newly emerging and reemerging zoonotic diseases. Therefore, understanding and addressing these factors is essential for effective prevention and adaptation of control measures to mitigate the high risk of zoonotic disease emergence, re-emergence, transmission, and spreading in livestock and human populations.

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