Genetic Variation at 15 Autosomal STR Loci Among Seven Egyptian Populations

AbdEl-Hafez, Ahmed F.; El-Alfy, Sherif H.; Swelim, Hamdy Hamed; Hassan, Neveen A.

doi:10.1007/s10528-018-9879-0

Cited by 8 publications

(1 citation statement)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This includes studies on Armenia/Turkey/Caucasus/Georgia, [34][35][36] Afghanistan, 37 and Arab countries, 32,[38][39][40] as well as Russia, 41 whose southern part is considered to have hosted the speakers of Proto-Indo-European (PIE), Pakistan, 42 India, 43 Greece, 44 the Levant, 45 Central Asian Uyghurs 46 and East and West Africans. 47,48 Nevertheless, Y-STR data from Iran are sparse, both with respect to the geographical and ethnical coverage. A study from 2009 compiled Y-filer data of 259 males from six ethnic groups in Iran and Azerbaijan, 49 complemented by another 259 Y-filer samples from the East and Southeast of Iran.…”

Section: Introductionmentioning

confidence: 99%

Genetic Analysis of 27 Y-STR Haplotypes in 11 Iranian Ethnic Groups

Alinaghi,

Mohseni,

Fattahi

et al. 2024

Arch Iran Med

View full text Add to dashboard Cite

Background: The study of Y-chromosomal variations provides valuable insights into male susceptibility in certain diseases like cardiovascular disease (CVD). In this study, we analyzed paternal lineage in different Iranian ethnic groups, not only to identify developing medical etiology, but also to pave the way for gender-specific targeted strategies and personalized medicine in medical genetic research studies. Methods: The diversity of eleven Iranian ethnic groups was studied using 27 Y-chromosomal short tandem repeat (Y-STR) haplotypes from Y-filer® Plus kit. Analysis of molecular variance (AMOVA) based on pair-wise RST along with multidimensional scaling (MDS) calculation and Network phylogenic analysis was employed to quantify the differences between 503 unrelated individuals from each ethnicity. Results: Results from AMOVA calculation confirmed that Gilaks and Azeris showed the largest genetic distance (RST=0.35434); however, Sistanis and Lurs had the smallest considerable genetic distance (RST=0.00483) compared to other ethnicities. Although Azeris had a considerable distance from other ethnicities, they were still close to Turkmens. MDS analysis of ethnic groups gave the indication of lack of similarity between different ethnicities. Besides, network phylogenic analysis demonstrated insignificant clustering between samples. Conclusion: The AMOVA analysis results explain that the close distance of Azeris and Turkmens may be the effect of male-dominant expansions across Central Asia that contributed to historical and demographics of populations in the region. Insignificant differences in network analysis could be the consequence of high mutation events that happened in the Y-STR regions over the years. Considering the ethnic group affiliations in medical research, our results provided an understanding and characterization of Iranian male population for future medical and population genetics studies.

show abstract