Genetic variation at the catalytic subunit of glutamate cysteine ligase contributes to the susceptibility to sporadic colorectal cancer: a pilot study

Bykanova, Marina; Solodilova, Maria; Azarova, Iuliia; Klyosova, Elena; Бушуева, О. Ю.; Polonikova, Anna; Churnosov, Mikhail; Polonikov, Alexey

doi:10.1007/s11033-022-07406-0

Cited by 4 publications

(3 citation statements)

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“…Additionally, a significant genotype × gender interaction was found in the rs79361899 recessive model. Gender-specific associations between certain polymorphisms and various types of cancer have frequently been observed, including gallbladder carcinoma [ 21 ], lung cancer [ 2 ], and colorectal cancer [ 22 ]. The exploration of SNP interactions facilitates understanding the intricate gene-environment interplay (G × E) [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

CD147 TagSNP is associated with the vulnerability to lung cancer in the Chinese population: a case–control study

Xie,

Huang,

Zhou

et al. 2024

Discov Onc

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Background Lung cancer, with its high morbidity and mortality, presents a major significant public health challenge. CD147, linked to cancer progression and metastasis, is a promising therapeutic target, including for lung cancer. The genetic variation may influence the expression of the gene and consequently the risk of lung cancer. This study aims to investigate single nucleotide polymorphisms (SNPs) in CD147 to understand their association with the risk of developing lung cancer in the Han Chinese population. Methods A hospital-based case–control investigation was conducted, enrolling 700 lung cancer patients and 700 cancer-free controls. TagSNPs were selected using Haploview v4.2, and genotype data from the 1000 Genomes Project database were utilized. The selected SNPs (rs28992491, rs67945626, and rs79361899) within the CD147 gene were evaluated using the improved multiple ligation detection reaction method. Statistical analysis included chi-square tests, logistic regression models, and interaction analyses. Results Baseline characteristics of the study population showed no significant differences in gender distribution between cases and controls, but there was a notable difference in smoking rates. No significant associations were found between the three TagSNPs and lung cancer susceptibility in the codominant model. However, stratification analyses revealed interesting findings. Among females, the rs79361899 AA/AG genotype was associated with an increased risk of lung cancer. In individuals aged ≥ 65 years old, the rs28992491 GG and rs79361899 AA genotypes were linked to a higher susceptibility. Furthermore, an interaction analysis demonstrated significant genotype × gender interactions in the rs79361899 recessive model, indicating an increased lung cancer risk in female carriers of the heterozygous or homozygous polymorphic genotype. Conclusions CD147 polymorphisms play an important role in lung cancer development, particularly in specific subgroup of age and gender. These findings highlight the significance of incorporating genetic variations and their interactions with demographic factors in comprehending the intricate etiology of lung cancer.

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Section: Discussionmentioning

confidence: 99%

CD147 TagSNP is associated with the vulnerability to lung cancer in the Chinese population: a case–control study

Xie,

Huang,

Zhou

et al. 2024

Discov Onc

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“…Genetic polymorphisms of glutamate cysteine ligase that are correlated with a decrease in GCLC mRNA and protein expression, enzyme activity, and GSH content [ 47 , 48 , 49 , 50 , 51 ] represent attractive markers for studying the molecular mechanisms of psoriasis. Polymorphisms of the GCLC gene have been found to be associated with the risk of cardiometabolic diseases such as coronary artery disease [ 52 , 53 ], ischemic stroke [ 54 ], type 1 [ 55 , 56 ] and type 2 [ 51 ] diabetes mellitus, polycystic ovary syndrome [ 57 ], and nonalcoholic fatty liver disease [ 58 ], as well as other multifactorial disorders such as bronchial asthma [ 59 ], pulmonary tuberculosis [ 60 ], and colorectal cancer [ 61 ]. However, no studies have been designed so far to investigate the role of GCLC gene polymorphisms in psoriasis susceptibility.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of the GCLC Gene Are Novel Genetic Markers for Susceptibility to Psoriasis Associated with Alcohol Abuse and Cigarette Smoking

Efanova,

Bushueva,

Saranyuk

et al. 2023

Life

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The aim of this pilot study was to investigate whether single nucleotide polymorphisms (SNP) in the gene encoding the catalytic subunit of glutamate cysteine ligase (GCLC) are associated with the risk and clinical features of psoriasis. A total of 944 unrelated individuals, including 474 patients with a diagnosis of psoriasis and 470 healthy controls, were recruited for the study. Six common SNPs in the GCLC gene were genotyped using the MassArray-4 system. Polymorphisms rs648595 (OR = 0.56, 95% CI 0.35–0.90; Pperm = 0.017) and rs2397147 (OR = 0.54, 95% CI 0.30–0.98; Pperm = 0.05) were associated with susceptibility to psoriasis in males. In the male group, diplotype rs2397147-C/C × rs17883901-G/G was associated with a decreased risk of psoriasis (FDR-adjusted p = 0.014), whereas diplotype rs6933870-G/G × rs17883901-G/G (FDR-adjusted p = 0.045) showed an association with an increased disease risk in females. The joint effects of SNPs with tobacco smoking (rs648595 and rs17883901) and alcohol abuse (rs648595 and rs542914) on psoriasis risk were observed (Pperm ≤ 0.05). We also found multiple sex-independent associations between GCLC gene polymorphisms and various clinical features such as earlier disease onset, the psoriatic triad, and specific localizations of skin lesions. The present study is the first to show that polymorphisms of the GCLC gene are significantly associated with the risk of psoriasis and related to its clinical features.

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“…The activation of NRF2 can regulate the transcription of ARE with cytoprotection and detoxification effects, such as HO-1 and NQO1, to maintain cell redox homeostasis and reduce cell oxidative stress [58]. The catalytic subunit of GCLC is an enzyme that plays a pivotal role in initiating and controlling the rate-limiting step of glutathione biosynthesis, and the lack of glutathione is related to the increase in the sensitivity of the host to oxidative stress [59]. Following ROS exposure, NRF2 migrates to the cell The stimulation of H 2 O 2 can cause the oxidation of protein as well as DNA damage in cells and constantly produces •OH radicals, thus leading to the generation of new H 2 O 2 and triggering a chain reaction of oxidative stimulation [54].…”

Section: Evaluation Of Cell Model For Preventing H 2 O 2 -Induced Per...mentioning

confidence: 99%

Preparation, Characterization, and Antioxidant Properties of Selenium-Enriched Tea Peptides

Wei,

Zhou

et al. 2023

Foods

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The research on the activity of selenium (Se)-enriched agricultural products is receiving increasing attention since Se was recognized for its antioxidant activities and for its enhancement of immunity in trace elements. In this study, antioxidant Se-containing peptides, namely, Se-TAPepI-1 and Se-TAPepI-2, were optimally separated and prepared from Se-enriched tea protein hydrolysates by ultrafiltration and Sephadex G-25 purification, and subsequently, their physicochemical properties, oligopeptide sequence, and potential antioxidant mechanism were analyzed. Through the optimization of enzymatic hydrolysis conditions, the Se-enriched tea protein hydrolyzed by papain exhibited a better free radical scavenging activity. After separation and purification of hydrolysates, the two peptide fractions obtained showed significant differences in selenium content, amino acid composition, apparent morphology, peptide sequence, and free radical scavenging activity. Therein, two peptides from Se-TAPepI-1 included LPMFG (563.27 Da) and YPQSFIR (909.47 Da), and three peptides from Se-TAPepI-2 included GVNVPYK (775.42 Da), KGGPGG (552.24 Da), and GDEPPIVK (853.45 Da). Se-TAPepI-1 and Se-TAPepI-2 could ameliorate the cell peroxidation damage and inflammation by regulating NRF2/ARE pathway expression. Comparably, Se-TAPepI-1 showed a better regulatory effect than Se-TAPepI-2 due to their higher Se content, typical amino acid composition and sequence, higher surface roughness, and a looser arrangement in their apparent morphology. These results expanded the functional activities of tea peptide and provided the theoretical basis for the development of Se-containing peptides from Se-enriched tea as a potential natural source of antioxidant dietary supplements.

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Genetic variation at the catalytic subunit of glutamate cysteine ligase contributes to the susceptibility to sporadic colorectal cancer: a pilot study

Cited by 4 publications

References 50 publications

CD147 TagSNP is associated with the vulnerability to lung cancer in the Chinese population: a case–control study

CD147 TagSNP is associated with the vulnerability to lung cancer in the Chinese population: a case–control study

Polymorphisms of the GCLC Gene Are Novel Genetic Markers for Susceptibility to Psoriasis Associated with Alcohol Abuse and Cigarette Smoking

Preparation, Characterization, and Antioxidant Properties of Selenium-Enriched Tea Peptides

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