Genetic variation in chromosomal translocation breakpoint and immune function genes and risk of non-Hodgkin lymphoma

Abstract

We found no support for a role of the studied variants in BCL2, CCND1, or MYC in risk of NHL or subtypes, but we provide further evidence of putative susceptibility loci in TNF and IL10 for specific NHL subtypes.

Polymorphic Variation of Inflammation-related Genes and Risk of Non-Hodgkin Lymphoma for Uygur and Han Chinese in Xinjiang

“…Subsequently, Purdue et al (2007) was able to establish similar results, wherein, the polymorphic variations in IL-10 and TNF genes could increase the risk of NHL. Fernberg et al (2010) also described that variant alleles in IL-10-3575 (rs1800890) can increase the risk of diffuse large B-cell lymphomas, but found no associations between the polymorphisms of TNF-α-G308A (rs1800629) and the pathogenesis of DLBCL. However, this study highlighted notable associations between TNF-α-308, T-cell lymphoma and mantle cell lymphoma.…”

Mantle Cell Lymphoma Presenting as a Gastric Mass & Multiple Lymphomatous Polyposis of the Duodenum: A Case Report and Review of the Literature

“…In addition, Asian/Pacific islander patients had significantly more common involvement of extra-nodal primary sites than white or black patients. These ethnic differences may be a result of genetic or other environmental and lifestyle factors [65][66][67][68][69][70], and future exploration of them may help in elucidating the etiology of MCL. Both pleural effusions and ascites were seen in this case.…”

Risk factors for etiology and prognosis of mantle cell lymphoma

“…In a study recently conducted in northern Europe with 120 MCLs, TNF rs1800629 was associated with an increased risk of MCL (OR=2.8, 95% CI 1.4–5.9) [55]; however, this association was not confirmed in a large, pooled study [11]. IL10 rs1800890 was also associated with an increased MCL risk in the European study, whereas the pooled study reported that IL10 variant rs1800896 was risk-associated [56].…”