Genetic variation in EYA4 on the risk of noise-induced hearing loss in Chinese steelworks firm sample

Yang, Qiuyue; Xu, Xiangrong; Jiao, Jie; Zheng, Yuxin; He, Lihua; Yu, Shanfa; Gu, Guizhen; Chen, Guoshun; Zhou, Wenhui; Wu, Hui; Li, Yanhong; Zhang, Huanling; Zhang, Zeng-Rui

doi:10.1136/oemed-2016-103613

Cited by 9 publications

(6 citation statements)

References 24 publications

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“…While occupational noise exposure is regulated, a person’s lifetime noise exposure is extremely difficult to quantify. The effects of noise exposure may be combined with other effects from smoking, impaired vascular flow, and genetic predisposition (Yang et al 2016). These factors make identifying noise exposure as the sole contributor to a person’s hearing loss impossible.…”

Section: Discussionmentioning

confidence: 99%

Effects of noise overexposure on tone detection in noise in nonhuman primates

et al. 2018

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This report explores the consequences of acoustic overexposures on hearing in noisy environments for two macaque monkeys trained to perform a reaction time detection task using a Go/No-Go lever release paradigm. Behavioral and non-invasive physiological assessments were obtained before and after narrowband noise exposure. Physiological measurements showed elevated auditory brainstem response (ABR) thresholds and absent distortion product otoacoustic emissions (DPOAEs) post-exposure relative to pre-exposure. Audiograms revealed frequency specific increases in tone detection thresholds, with the greatest increases at the exposure band frequency and higher. Masked detection was affected in a similar frequency specific manner: threshold shift rates (change of masked threshold per dB increase in noise level) were lower than pre-exposure values at frequencies higher than the exposure band. Detection thresholds in sinusoidally amplitude modulated (SAM) noise post-exposure showed no difference from those in unmodulated noise, whereas pre-exposure masked detection thresholds were lower in the presence of SAM noise compared to unmodulated noise. These frequency-dependent results were correlated with cochlear histopathological changes in monkeys that underwent similar noise exposure. These results reveal that behavioral and physiological effects of noise exposure in macaques are similar to those seen in humans and provide preliminary information on the relationship between noise exposure, cochlear pathology and perceptual changes in hearing within individual subjects.

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Section: Discussionmentioning

confidence: 99%

Effects of noise overexposure on tone detection in noise in nonhuman primates

et al. 2018

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“…Dobie and Humes (2017) have suggested that humans are less susceptible to TTS and argue that they are therefore less likely to sustain noise-induced cochlear synaptopathy than rodents. There is also evidence that certain individuals may be more or less genetically susceptible to damage from noise exposure/s than others (Abreu-Silva et al, 2011;Kowalski et al, 2014;Yang et al, 2016;Zhang et al, 2014). Furthermore, there may be interactive effects between genetic susceptibility and environmental factors, such as exposure to ototoxic agents.…”

Section: Differences Between Animal and Human Researchmentioning

confidence: 99%

The effects of noise exposure and musical training on suprathreshold auditory processing and speech perception in noise

et al. 2017

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Recent animal research has shown that exposure to single episodes of intense noise causes cochlear synaptopathy without affecting hearing thresholds. It has been suggested that the same may occur in humans. If so, it is hypothesized that this would result in impaired encoding of sound and lead to difficulties hearing at suprathreshold levels, particularly in challenging listening environments. The primary aim of this study was to investigate the effect of noise exposure on auditory processing, including the perception of speech in noise, in adult humans. A secondary aim was to explore whether musical training might improve some aspects of auditory processing and thus counteract or ameliorate any negative impacts of noise exposure. In a sample of 122 participants (63 female) aged 30-57 years with normal or near-normal hearing thresholds, we conducted audiometric tests, including tympanometry, audiometry, acoustic reflexes, otoacoustic emissions and medial olivocochlear responses. We also assessed temporal and spectral processing, by determining thresholds for detection of amplitude modulation and temporal fine structure. We assessed speech-in-noise perception, and conducted tests of attention, memory and sentence closure. We also calculated participants' accumulated lifetime noise exposure and administered questionnaires to assess self-reported listening difficulty and musical training. The results showed no clear link between participants' lifetime noise exposure and performance on any of the auditory processing or speech-in-noise tasks. Musical training was associated with better performance on the auditory processing tasks, but not the on the speech-in-noise perception tasks. The results indicate that sentence closure skills, working memory, attention, extended high frequency hearing thresholds and medial olivocochlear suppression strength are important factors that are related to the ability to process speech in noise.

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“…Current studies have shown that the polymorphisms of potassium ion channel genes (like KCNQ4 and KCNE1 ) [ 14 , 15 ], catalase ( CAT ), protocadherin 15 ( PCDH15 ), myosin 14 ( MYH14 ) [ 16 ] and heart shock protein ( HSP70 ) [ 17 ] detected in different populations are significantly related to the development of NIHL. In addition, studies conducted by our research group has also found that heart shock protein ( HSP70 ) [ 18 ], eye absent homolog 4 ( EYA4 ) [ 19 ], suggestive POU-domain transcription POU4F3 and Grainyhead-like2 ( GRHL2 ) [ 20 ] may be associated with the susceptibility to NIHL.…”

Section: Introductionmentioning

confidence: 99%

Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study

Jiao

Chen

et al. 2018

BMC Med Genet

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BackgroundNoise-induced hearing loss (NIHL) is a complex, irreversible disease caused by the interaction of genetic and environmental factors. In recent years, a great many studies have been done to explore the NIHL susceptibility genes among humans. So far, high powerful detections have been founded that genes of potassium ion channel genes (KCNQ4 and KCNE1), catalase (CAT), protocadherin 15 (PCDH15), myosin 14 (MYH14) and heart shock protein (HSP70) which have been identified in more than one population may be associated with the susceptibility to NIHL. As for metabolic glutamate receptor7 gene (GRM7), a lot of researches mainly focus on age-related hearing loss (ARHL) and the results have shown that the polymorphisms of GRM7 are linked to the development of ARHL. However, little is known about the association of GRM7 and the susceptibility to NIHL. Therefore, the aim of this study was to explore the effect of GRM7 polymorphisms on the susceptibility to NIHL.MethodsA nested case-control study based on the cohort in a Chinese steel factory was implemented in 292 cases and 584 controls matched with the same sex, the age difference ≤ 5 years old, the same type of work, duration of occupational noise exposure ≤2 years. Five single nucleotide polymorphisms (SNPs) of GRM7 were gained through selecting and genotyping SNPs. Conditional logistic regression analysis was used to assess the main effect of GRM7 polymorphisms on the susceptibility to NIHL and the gene-by-environment interaction. Furthermore, the gene-by-gene interactions were analyzed by generalized multiple dimensionality reduction (GMDR).ResultsThis research discovered for the first time that the mutant allele C in rs1485175 of the GMR7 may decrease individuals’ susceptibility to NIHL. The interaction between rs1485175 and cumulative noise exposure (CNE) at high level was found after the stratification according to CNE (p/pbon = 0.014/0.007, OR = 0.550, 95% CI: 0.340–0.891). Permutation test of GMDR suggested that rs1920109, rs1485175 and rs9826579 in GRM7 might interact with each other in the process of developing NIHL (p = 0.037).ConclusionsThe results suggest that the mutant allele C of rs1485175 in GRM7 may reduce the susceptibility to NIHL in Chinese Han population.Electronic supplementary materialThe online version of this article (10.1186/s12881-017-0515-3) contains supplementary material, which is available to authorized users.

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Genetic variation in EYA4 on the risk of noise-induced hearing loss in Chinese steelworks firm sample

Abstract: The research suggests that EYA4 genetic variant and its interaction with noise levels may modify the susceptibility to develop noise-induced hearing loss in Chinese population.

Cited by 9 publications

References 24 publications

Effects of noise overexposure on tone detection in noise in nonhuman primates

Effects of noise overexposure on tone detection in noise in nonhuman primates

The effects of noise exposure and musical training on suprathreshold auditory processing and speech perception in noise

Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study

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