Genetic variation in microRNA-100 (miR-100) rs1834306 T/C associated with Hepatitis B virus (HBV) infection: Correlation with expression level

Motawi, Tarek K.; Mady, Amira; Shaheen, Samar; El-Shenawy, Soha Z.; Talaat, Roba M.; Rizk, Sherine M.

doi:10.1016/j.meegid.2019.06.009

Cited by 13 publications

(16 citation statements)

References 35 publications

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“…In the past, Motawi et al verified that miR-100 rs1834306 G allele reduced the expression of miR-100 in hepatitis B. 44 It seemed to conflict with our prediction that GG genotype would increase miR-100 expression to promote HSCR by directly/indirectly suppressing the functions of HSCR-associated pathways. The explanations for this contradiction were as follows.…”

Section: Discussioncontrasting

confidence: 73%

miR-100 rs1834306 A>G Increases the Risk of Hirschsprung Disease in Southern Chinese Children

Zhu¹,

Ao²,

Zheng³

et al. 2020

PGPM

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Background: Hirschsprung disease (HSCR) is a rare congenital gastrointestinal disease characterized by the absence of intestinal submucosal and myometrial ganglion cells. Recently, researches indicated that miR-100 regulated the growth, differentiation and apoptosis of neurons, and affected the functions of HSCR-associated pathways. While miR-100 rs1834306 A>G polymorphism was shown to modify the susceptibility to tumors, the association between this polymorphism and HSCR susceptibility is still unknown. Methods: This was a case-control study consisting of 1470 HSCR cases and 1473 controls from southern China. DNA was genotyped by TaqMan real-time PCR. Odds ratios (ORs) and 95% confidence intervals (CIs) were used as statistical indicators. Results: We found that miR-100 rs1834306 G allele and GG genotype significantly increased HSCR susceptibility (GG vs AA: adjusted OR=1.31, 95% CI=1.04-1.64, P=0.020; G vs A: adjusted OR=1.12, 95% CI=1.01-1.25, P=0.041; GG vs AA/AG: adjusted OR=1.30, 95% CI=1.07-1.59, P=0.010). In the stratified analysis, miR-100 rs1834306 GG genotype carriers had higher risk to develop HSCR in all clinical subtypes when compared with those with AA/AG genotypes, and OR was rising with HSCR aggravation (SHSCR: adjusted OR=1.28, 95% CI=1.03-1.59, P=0.029; LHSCR: adjusted OR=1.48, 95% CI=1.06-2.07, P=0.020; TCA: adjusted OR=2.12, 95% CI=1.22-3.69, P=0.008). Conclusion: Our findings suggested that miR-100 rs1834306 A>G polymorphism was associated with increased HSCR susceptibility in southern Chinese children. Furthermore, miR-100 rs1834306 GG genotype had a greater genetic pathopoiesis in severe HSCR.

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Section: Discussioncontrasting

confidence: 73%

miR-100 rs1834306 A>G Increases the Risk of Hirschsprung Disease in Southern Chinese Children

Zhu¹,

Ao²,

Zheng³

et al. 2020

PGPM

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“…In accordance with this result, Liu et al (2012) [39]. and Motawi et al (2019) [40]. reported that the AC genotype is the most frequent in the Chinese population and Egyptian population, respectively.…”

Section: Discussionsupporting

confidence: 53%

“…(2019) [27]. One hundred healthy controls with normal liver function tests and no history of previous liver disease and negative HBV and HCV serology were enrolled in the study.…”

Section: Patient Characteristics and Study Designmentioning

confidence: 99%

miR-372 (rs12983273) and LncRNA HULC (rs7763881) Genetic Polymorphisms and Susceptibility to Hepatitis B Virus (HBV) Infection

Talaat

Shahen

El-Shenawy

et al. 2021

Preprint

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MicroRNAs (miRNAs) and Long non-coding RNAs (lncRNAs) are two major types of non-coding RNAs (ncRNAs) with regulatory roles. Genetic variation in the miRNAs and lncRNAs has been involved in the initiation and progression of many diseases. miRNA-LncRNA interactions are implicated in the regulation of many diseases, such as hepatitis infection. In this study, we assumed that single nucleotide polymorphisms (SNPs) in miR-372 (rs28461391 C/T) and HULC (rs7763881 A/C) might participate in HBV infection risk. SNPs rs28461391 in miR-372 and rs7763881 in HULC were genotyped in 100 HBV patients and 100 healthy controls using the Polymerase chain reaction sequence-specific primer technique (PCR-SSP). Our results showed no significant difference in miR-372 rs12983273 genotype distribution between both controls and HBV patients. On the other hand, there was a significant increase in HULC rs7763881 CC genotype (P<0.05) coincides with a significant decrease in AC genotype distribution (P<0.05) in HBV patients as compared to controls. Our results showed that the CC genotype is associated with an increased risk of HBV infection (OR= 3.43; CI: 1.3-9.07) while AA genotype is a protective one (OR= 0.3; CI: 0.13-9.07). Our results suggest that HULC rs7763881 A/C might be a biomarker for HBV susceptibility. However, larger sample studies are recommended to verify our preliminary data. To the best of our knowledge, the present study was the first to investigate the relevance of miR-372 (rs28461391 C/T) and HULC (rs7763881 A/C) gene polymorphisms to the risk of HBV infection in the Egyptian population.

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“…It is well known that the interaction between host immunity and viral replication influences the clinical outcome of HBV infection, and more attention is currently paid to the genetic background influence [22,23]. Gene polymorphisms such as SNPs may change the structure or biological function of the corresponding protein.…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphisms of interleukin-6 influence the development of hepatitis B virus-related liver cirrhosis in the Han Chinese population

Xia

Zhu

Huang

et al. 2020

Infection, Genetics and Evolution

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Genetic variation in microRNA-100 (miR-100) rs1834306 T/C associated with Hepatitis B virus (HBV) infection: Correlation with expression level

Cited by 13 publications

References 35 publications

<p><em>miR-100</em> rs1834306 A>G Increases the Risk of Hirschsprung Disease in Southern Chinese Children</p>

<p><em>miR-100</em> rs1834306 A>G Increases the Risk of Hirschsprung Disease in Southern Chinese Children</p>

miR-372 (rs12983273) and LncRNA HULC (rs7763881) Genetic Polymorphisms and Susceptibility to Hepatitis B Virus (HBV) Infection

Genetic polymorphisms of interleukin-6 influence the development of hepatitis B virus-related liver cirrhosis in the Han Chinese population

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