Genetic variation in serological response to Mycobacterium avium subspecies paratuberculosis and its association with performance in Irish Holstein–Friesian dairy cows

Berry, D.P.; Good, Margaret; Mullowney, Peter C.; Cromie, A.R.; More, Simon J.

doi:10.1016/j.livsci.2010.03.007

Cited by 24 publications

(27 citation statements)

References 19 publications

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“…Pritchard et al (2017a) reported that genetic correlations between MAP antibody response and different fertility traits were low, negative, and not significant. Additionally, Berry et al (2010) found low, nonsignificant correlations between MAP serological response and calving interval and perinatal mortality. In the context of longevity, a higher culling rate among cows testing positive for MAP infection is expected (Hendrick et al, 2005;Smith et al, 2010).…”

Section: Correlations With Other Traitsmentioning

confidence: 89%

The genetic architecture of milk ELISA scores as an indicator of Johne's disease (paratuberculosis) in dairy cattle

Brito

Mallikarjunappa

Sargolzaei

et al. 2018

Journal of Dairy Science

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Johne's disease (or paratuberculosis), caused by Mycobacterium avium ssp. paratuberculosis (MAP) infection, is a globally prevalent disease with severe economic and welfare implications. With no effective treatment available, understanding the role of genetics influencing host infection status is essential to develop selection strategies to breed for increased resistance to MAP infection. The main objectives of this study were to estimate genetic parameters for the MAP-specific antibody response using milk ELISA scores in Canadian Holstein cattle as an indicator of resistance to Johne's disease, and to unravel genomic regions and candidate genes significantly associated with MAP infection. After data editing, 168,987 milk ELISA records from 2,306 herds, obtained from CanWest Dairy Herd Improvement, were used for further analyses. Variance and heritability estimates for MAP infection status were determined using univariate linear animal models under 3 scenarios: (a) SCEN1: the complete data set (all herds); (b) SCEN2: herds with at least one suspect or test-positive animal (ELISA optical density ≥0.07); and (c) SCEN3: herds with at least one test-positive animal (ELISA optical density ≥0.11). Heritability estimates were calculated as 0.066, 0.064, and 0.063 for SCEN1, SCEN2, and SCEN3, respectively. The correlations between estimated breeding values for resistance to MAP infection and other economically important traits, when significant, were favorable and of low magnitude. Genome-wide association analyses identified important genomic regions on Bos taurus autosome (BTA)1, BTA7, BTA9, BTA14, BTA15, BTA17, BTA19, and BTA25 showing significant association with MAP infection status. These regions included 2 single nucleotide polymorphisms located 2 kb upstream of positional candidate genes CD86 and WNT9B, which play key roles in host immune response and tissue homeostasis. This study revealed the genetic architecture of MAP infection in Canadian Holstein cattle as measured by milk ELISA scores by estimating genetic parameters along with the identification of genomic regions potentially influencing MAP infection status. These findings will be of significant value toward implementing genetic and genomic evaluations for resistance to MAP infection in Holstein cattle.

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Section: Correlations With Other Traitsmentioning

confidence: 89%

The genetic architecture of milk ELISA scores as an indicator of Johne's disease (paratuberculosis) in dairy cattle

Brito

Mallikarjunappa

Sargolzaei

et al. 2018

Journal of Dairy Science

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“…Studies differ on whether the trait is measured as continuous or categorized as a binary trait (negative/ positive) or categorical trait. In Israeli Holstein (Shook et al, 2012) and Irish Holstein-Friesian (Berry et al, 2010), ELISA tests from serum were analyzed as a binary trait, which gave heritability estimates of 0.16 and 0.15, respectively, from a threshold model. Berry et al (2010) also made the comparison between a threshold and a linear model, as well as analyzing the trait as binary or continuous and obtained lower estimates from the linear model of 0.10 as a binary trait and 0.07 as a continuous trait.…”

Section: Genetic Parameter Estimationmentioning

confidence: 99%

“…2 Herd group: 1 = herds with ≤5% positive tests; 2 = herds with >5 and ≤10% positive tests; 3 = herds with >10% positive tests. Attalla et al, 2010;Berry et al, 2010). Mortensen et al (2004) reported low and nonsignificant genetic correlations between AR-MAP and daily milk yield (−0.04).…”

Section: Productionmentioning

confidence: 99%

“…Genetic improvement of disease resistance is a slow and long-term process; however, the results are permanent and cumulative. The heritability of Johne's disease susceptibility has been estimated using milk ELISA (Mortensen et al, 2004;Attalla et al, 2010;van Hulzen et al, 2011), slaughtered animals (Koets et al, 2000), blood serum (Gonda et al, 2006;Hinger et al, 2008;Berry et al, 2010), and fecal culture (Gonda et al, 2006;Küpper et al, 2012) from several countries. Country-specific genetic parameter estimation is valuable, as it can be influenced by disease prevalence (van Hulzen et al, 2011;Küpper et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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The genetics of antibody response to paratuberculosis in dairy cattle

Pritchard

Mrode

Coffey

et al. 2017

Journal of Dairy Science

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Genetic parameters were estimated for antibody response to paratuberculosis (Mycobacterium avium ssp. paratuberculosis) using milk ELISA test results, collected and analyzed by National Milk Records, from Holstein Friesian cows on UK dairy farms in their first 3 lactations. Milk ELISA test results were obtained from 2007 to 2012 and combined with milk recording data and pedigree information. The reduced data set edited for the purposes of genetic parameter estimation consisted of 148,054 milk ELISA records from 64,645 lactations in 40,142 cows of 908 sires, recorded in 641 herds. Milk ELISA test results were log-transformed and univariate analysis of 3 alternative animal models and equivalent sire models were considered. The most appropriate model included additive genetic and permanent environmental random effects, whereas maternal effects were significant according to likelihood ratio test and Akaike's information criterion but not for Bayesian information criterion. Heritability and repeatability estimates were 0.06 and 0.37, respectively, for the chosen animal model and its equivalent sire model. A subset of the data including herds with greater than 10% positive tests gave a slightly higher heritability of 0.08. Favorable but generally low significant genetic correlations were obtained between antibody response with 305-d milk yield (-0.16), 305-d protein yield (-0.16), log-transformed lactation-average somatic cell count (0.15), and the number of mastitis episodes (0.22). Thus, selection on the antibody response to paratuberculosis, should not be detrimental to production or udder health traits. Testing cattle for paratuberculosis is important for its use in control programs and although the heritability of antibody response was low, breeding against the disease might be a good prospect as a preventative measure to assist together with other approaches in an overall control strategy.

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“…The heritability of Johne’s disease resistance or susceptibility in this stud herd was estimated to be 0.30 +/− 0.06 (J.F.T Griffin, Disease Research Laboratory, unpublished data) whereas heritability in crossbred deer herds has been estimated to be 0.2 [11]. An estimated heritability for susceptibility to MAP infection in a herd of Dutch dairy cattle was lower at 0.06 [7] while heritability for the production of antibody to MAP was estimated at 0.15 for Irish dairy cows [12] and 0.10 for Danish dairy cows [13]. Moreover, findings from Johne’s disease research in sheep suggest that a resistant phenotype exists where the animal prevents the establishment of MAP infection [14] or the infected animal is able to cure itself over a period of time [15].…”

Section: Introductionmentioning

confidence: 99%

Innate immune markers that distinguish red deer (Cervus elaphus) selected for resistant or susceptible genotypes for Johne's disease

Dobson¹,

Liggett²,

O’Brien³

et al. 2013

Vet Res

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While many factors contribute to resistance and susceptibility to infectious disease, a major component is the genotype of the host and the way in which it is expressed. Johne’s disease is a chronic inflammatory bowel disease affecting ruminants and is caused by infection with Mycobacterium avium subspecies paratuberculosis (MAP). We have previously identified red deer breeds (Cervus elaphus) that are resistant; have a low rate of MAP infection and do not progress to develop Johne’s disease. In contrast, susceptible breeds have a high rate of MAP infection as seen by seroconversion and progress to develop clinical Johne’s disease. The aim of this study was to determine if immunological differences exist between animals of resistant or susceptible breeds. Macrophage cultures were derived from the monocytes of deer genotypically defined as resistant or susceptible to the development of Johne’s disease. Following in vitro infection of the cells with MAP, the expression of candidate genes was assessed by quantitative PCR as well as infection rate and cell death rate. The results indicate that macrophages from susceptible animals show a significantly higher upregulation of inflammatory genes (iNOS, IL-1α, TNF-α and IL-23p19) than the macrophages from resistant animals. Cells from resistant animals had a higher rate of apoptosis at 24 hours post infection (hpi) compared to macrophages from susceptible animals. The excessive expression of inflammatory mRNA transcripts in susceptible animals could cause inefficient clearing of the mycobacterial organism and the establishment of disease. Controlled upregulation of inflammatory pathways coupled with programmed cell death in the macrophages of resistant animals may predispose the host to a protective immune response against this mycobacterial pathogen.

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Genetic variation in serological response to Mycobacterium avium subspecies paratuberculosis and its association with performance in Irish Holstein–Friesian dairy cows

Cited by 24 publications

References 19 publications

The genetic architecture of milk ELISA scores as an indicator of Johne's disease (paratuberculosis) in dairy cattle

The genetic architecture of milk ELISA scores as an indicator of Johne's disease (paratuberculosis) in dairy cattle

The genetics of antibody response to paratuberculosis in dairy cattle

Innate immune markers that distinguish red deer (Cervus elaphus) selected for resistant or susceptible genotypes for Johne's disease

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