2021
DOI: 10.3390/ani11061635
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Genetic Variation in the Prion Protein Gene (PRNP) of Two Tunisian Goat Populations

Abstract: Scrapie is a fatal prion disease. It belongs to transmissible spongiform encephalopathies (TSEs), and occurs in sheep and goats. Similarly, to ovine species, the prion protein gene (PRNP) plays a major role in conferring resistance or susceptibility to TSE in goats. This study assesses the variability of PRNP in native and crossed-breed goat populations raised in the Southeast of Tunisia and provides information on the distribution of PRNP haplotypes and genotypes in these goat populations. A total of 116 unre… Show more

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Cited by 4 publications
(5 citation statements)
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“…The scrapie-positive goat analysed in our study was a female Banat’s White breed (GenBank ID: ON015441) without polymorphism associated with increased resistance (G37G, W102W, T110T, G127G, I142I, H143H, N146N, R151R, R154R, P168P, S173S, R211R, I218I, Q222Q, and S240S). The genotype ON015441 was consistent with our current understanding of which genotypes are susceptible [ 15 , 16 , 17 , 22 , 26 , 30 , 31 , 32 , 33 , 37 , 57 , 58 ].…”
Section: Discussionsupporting
confidence: 85%
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“…The scrapie-positive goat analysed in our study was a female Banat’s White breed (GenBank ID: ON015441) without polymorphism associated with increased resistance (G37G, W102W, T110T, G127G, I142I, H143H, N146N, R151R, R154R, P168P, S173S, R211R, I218I, Q222Q, and S240S). The genotype ON015441 was consistent with our current understanding of which genotypes are susceptible [ 15 , 16 , 17 , 22 , 26 , 30 , 31 , 32 , 33 , 37 , 57 , 58 ].…”
Section: Discussionsupporting
confidence: 85%
“…The scientific knowledge concerning genetic resistance to classical scrapie and polymorphisms of the PRNP gene in European goat breeds/populations is sufficient to consider the development of guidance on how to increase goat genetic resistance to classical scrapie by disseminating resistant alleles in goat breeds [ 15 , 19 , 26 , 28 , 35 , 37 , 44 , 48 , 49 ]; our data give particular information for a future Romanian guide of breeding goats resistant to scrapie. Moreover, our research covered two local breeds (a total of 103 GenBank IDs of Carpathian and Banat’s White were obtained) and one of the most common European goat breeds (French Alpine); it also generated data for future metanalyses.…”
Section: Discussionmentioning
confidence: 95%
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“…In addition, the PrP Sc of atypical scrapie is relatively sensitive to proteinases [ 30 , 31 ]. In the last 15 years, many polymorphisms associated with resistance/susceptibility to scrapie, such as 110T/P, 127G/S, 142M/I, 145G/D, 146N/D/S, 154R/H, 211R/Q, and 222Q/K have been described in different breeds of goats and regions [ 5 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. Based on these data and experimental challenge studies, the European Food Safety Authority (EFSA) has assigned the polymorphisms 222K, 146D, and 146S as acceptable candidates for breeding towards resistance against scrapie [ 13 , 41 ].…”
Section: Introductionmentioning
confidence: 99%