Genetic variation involved in the risk to external apical root resorption in orthodontic patients: a systematic review

Pinheiro, Liz Helena Moraes; Guimarães, Ludmila Silva; Küchler, Érika Calvano; Kirschneck, Christian; Antunes, Leonardo Santos

doi:10.1007/s00784-021-04074-5

Cited by 14 publications

(11 citation statements)

References 37 publications

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“…Its severity could be influenced by epistatic interactions of several genes and environmental factors [4, 5]. A recent systematic review showed that different SNPs in some genes had been associated with this condition in many populations [8]. A previous study evaluated the SNP rs731236 in VDR [9], suggesting a possible effect of this gene on the severity of external apical root resorption.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence has shown a hereditary component to external apical root resorption explaining patients’ predisposition to this outcome [6, 7]. Variants in genes that code for different biomarkers such as inflammatory mediators, osteoclastogenesis markers, or molecules that participate in tooth formation have been associated with this trait [8].…”

Section: Introductionmentioning

confidence: 99%

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Association between genetic variants in key vitamin‐D‐pathway genes and external apical root resorption linked to orthodontic treatment

Marañón‐Vásquez

Küchler²,

Hermann³

et al. 2023

European J Oral Sciences

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This study evaluated the association between single‐nucleotide polymorphisms (SNPs) in vitamin‐D‐related genes and the amount of external apical root resorption linked to orthodontic treatment. One hundred and forty‐three individuals were assessed. The amount of external apical root resorption of upper central incisors (EARRinc) and lower first molars (EARRmol) were evaluated in radiographs. Seven SNPs were genotyped across four genes including the vitamin D receptor [VDR], group‐specific component [GC], cytochrome P450 family 27 subfamily B member 1 [CYP27B1], and cytochrome P450 family 24 subfamily A member 1 [CYP24A1]. Linear regressions were implemented to determine allele‐effects on external apical root resorption. Individuals carrying the AA genotype in VDR rs2228570 had a 21% higher EARRmol than those having AG and GG genotypes (95% CI: 1.03,1.40). EARRmol in heterozygous rs2228570, was 12% lower than for homozygotes (95%CI: 0.78,0.99). Participants with the CCG haplotype (rs1544410‐rs7975232‐rs731236) in VDR had an EARRmol 16% lower than those who did not carry this haplotype. Regarding CYP27B1 rs4646536, EARRinc in participants who had at least one G allele was 42% lower than for homozygotes AA (95%CI: 0.37,0.93). Although these results did not remain significant after multiple testing adjustment, potential associations may still be suggested. Further replication studies are needed to confirm or refute these findings.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between genetic variants in key vitamin‐D‐pathway genes and external apical root resorption linked to orthodontic treatment

Marañón‐Vásquez

Küchler²,

Hermann³

et al. 2023

European J Oral Sciences

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“…Moreover, apical root resorption (ARR) has been associated with intrusion forces [35,36]. Risk factors, such us the force magnitude, the age of the patient, the tooth type, the treatment duration and the range of movement, should be taken into consideration [36][37][38]. Variances observed between activations on the same axis (i.e., between intrusion and extrusion or oral and vestibular activation) have multifactorial etiology.…”

Section: Discussionmentioning

confidence: 99%

Vertical and Orovestibular Forces Generated by Beta-Titanium and Stainless-Steel Rectangular Wires in Labial and Fully Customized Lingual Bracket Systems

et al. 2021

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This study aimed to investigate the force values exerted from rectangular wires when combined with conventional labial and fully customized lingual appliances under predefined, idealized activation. Fully customized lingual brackets of two brands Incognito™ (3M Unitek, Monrovia, MN, USA) and WIN (DW Lingual Systems, Bad Essen, Germany) and labial brackets of another brand, discovery® MIM and discovery® smart systems (Dentaurum, Ispringen, Germany), were chosen. Stainless-steel and beta-titanium wires of 0.018” × 0.025” were examined. For IncognitoTM, 0.0182” × 0.025” beta-titanium wires were tested. Intrusion/extrusion and orovestibular movements were performed in a range of 0.2 mm, and the forces were recorded for each 0.1 mm of the movement. Mean values and standard deviations were calculated for all measurements, and ANOVA was performed for statistical analysis. Slight differences were observed between the forces generated from beta-titanium and stainless-steel wires. The same wire generated in some cases 5–53% higher forces with the lingual appliance due to the vertical orientation of the long walls during intrusion/extrusion and increased wire stiffness at the anterior region. Beta-titanium and stainless-steel 0.018” × 0.025” wires can generate similar force values during the final stages of the orthodontic therapy; thus, possibly only one of the two alloys could be used in each orthodontic wire sequence.

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“…External root resorption in healthy deciduous teeth is part of the physiological process of replacing deciduous teeth with permanent teeth [1,3]. Sometimes external root resorption may start pathologically due to factors such as in ammation caused by pulp infection, trauma, and orthodontic forces [3][4][5]. External in ammatory root resorption is a rapid process that is clinically characterized by increased tooth loosening, tenderness to percussion, and dull sound in the percussion, often with stulas or swelling in the surrounding gingiva [3].…”

Section: Introductionmentioning

confidence: 99%

“…AR, actual resorption; SD, standard deviation; CI, confidence intervals; min, minimum; max, maximum 4. International Journal of Dentistry3.3.2.…”

mentioning

confidence: 99%

Diagnostic Accuracy of Periapical Radiography in Detection and Measurement of the External Root Resorption in Primary Molars: A Single-Blind Prospective Clinical Study

Taravati

Balak

Rakhshan

2022

International Journal of Dentistry

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Introduction. Identifying the external root resorption plays an important role in treatment planning for deciduous teeth. Although proper accuracy of digital radiography in the diagnosis of external root resorption has been established in permanent dentition, it cannot be at all generalized to the primary root being superimposed by the succeeding permanent teeth. Interestingly, no study has assessed this in primary teeth yet. Thus, this study was undertaken for the first time. Methods. This was a single-blind prospective clinical diagnostic study performed on 501 observations (observed by 3 observers) pertaining to 167 roots of 45 maxillary/mandibular primary molars (in 6–8-year-old patients) which were indicated for extraction and did have succeeding permanent teeth. Digital parallel periapical radiographs were taken before dental extraction using a PSP sensor. Radiographs were printed and examined by two pediatric dentists. After the extraction, the extent of resorption was directly measured, twice, by third and fourth observers blinded to radiographic estimates. Radiographic errors and absolute errors (mm) were calculated. Various parameters were analyzed statistically. Results. Of the roots, 56.3% were really resorbed with (mean = 5.01 ± 2.10 mm). First/second observers failed to identify 19.6% and 38.3% of roots, respectively. Average errors were −0.77 ± 2.31 and 0.14 ± 2.19 mm in girls and boys, respectively ( P = 0.043 , t-test). The factors “side, jaw, tooth type, and root type” did not affect errors ( P > 0.05 ). Average absolute errors were 1.79 ± 1.47 mm (significantly above zero, P < 0.0005 ). No evaluated factor affected it ( P > 0.1 ). Actual lesion sizes correlated with errors (Pearson R = 0.682, P < 0.0005 ) but not with absolute errors ( P = 0.464 ). Conclusion. Although many deciduous roots might be missed, digital radiography might still provide rather a good accuracy in diagnosis and measurement of external root resorption up to about 1.8 mm absolute error. Observers might overestimate resorption sizes in girls and in cases with actual lesions smaller than 3 mm. Size of the lesion can influence the direction of error (shortening/elongation), but not its directionless magnitude.

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Genetic variation involved in the risk to external apical root resorption in orthodontic patients: a systematic review

Cited by 14 publications

References 37 publications

Association between genetic variants in key vitamin‐D‐pathway genes and external apical root resorption linked to orthodontic treatment

Association between genetic variants in key vitamin‐D‐pathway genes and external apical root resorption linked to orthodontic treatment

Vertical and Orovestibular Forces Generated by Beta-Titanium and Stainless-Steel Rectangular Wires in Labial and Fully Customized Lingual Bracket Systems

Diagnostic Accuracy of Periapical Radiography in Detection and Measurement of the External Root Resorption in Primary Molars: A Single-Blind Prospective Clinical Study

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