Genetic variation of FASN is associated with fatty acid composition of Hanwoo

Yeon, Seong–Heum; Lee, S.H.; Choi, Bong Hwan; Lee, H.J.; Jang, Gul Won; Lee, K.T.; Kim, K.H.; Lee, Jeung Hee; Chung, Hoyoung

doi:10.1016/j.meatsci.2013.01.002

Cited by 17 publications

(12 citation statements)

References 28 publications

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“…FASN2 showed significant association with eye muscle area and Warner‐Bratzler shear force. Similar results were reported by Yeon et al . However, FASN1 and FASN2 showed only suggestive associations with stearic acid (C18:0) and palmitoleic acid (C16:1) respectively.…”

Section: Association Of Fasn1 Fasn2 Cyp7b1 Plag1 and Scd Snps Withsupporting

confidence: 89%

Genetic association of PLAG1,SCD,CYP7B1 and FASNSNPs and their effects on carcass weight, intramuscular fat and fatty acid composition in Hanwoo steers (Korean cattle)

et al. 2016

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Section: Association Of Fasn1 Fasn2 Cyp7b1 Plag1 and Scd Snps Withsupporting

confidence: 89%

Genetic association of PLAG1,SCD,CYP7B1 and FASNSNPs and their effects on carcass weight, intramuscular fat and fatty acid composition in Hanwoo steers (Korean cattle)

et al. 2016

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“…Yeon et al . () also searched the genetic variants in CDS of FASN gene in Hanwoo and identified 16 polymorphisms, including six non‐synonymous mutations. Genotypes of the g.15532A>C were significantly associated with C18:3 and genotypes of the g.17924G>A were significantly associated with C16:0, C16:1, C18:1, SFA and unsaturated fatty acid.…”

Section: Introductionmentioning

confidence: 97%

The g.841G>C SNP of FASN gene is associated with fatty acid composition in beef cattle

Hayakawa

Sakamoto

Ishii

et al. 2015

Animal Science Journal

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The objective of the current study is to evaluate the association between fatty acid composition and fatty acid synthase gene polymorphisms as responsible mutations. For this purpose, we selected seven previously reported single nucleotide polymorphisms (SNPs) in FASN gene, including one within promoter region (g.841G>C) and six non-synonymous SNPs (g.8805C>T, g.13126C>T, g.15532A>C, g.16024A>G, g.16039C>T, g.17924A>G), and genotyped them in Japanese Black cattle. Genotyping results revealed that g.8805 C>T and g.17924 A>G were monomorphic loci. Genome-wide association analysis including the other five SNPs revealed that only g.841G>C showed significant associations with the percentages of C14:0, C14:1, C16:1 and C18:1 at 5% genome-wide significance level. In order to further evaluate the effect, we genotyped g.841G>C using additional three populations, including two Japanese Black populations and a Holstein cattle population. g.16024A>G was also genotyped and included in the analysis because it has been reported to be associated with fatty acid composition in Japanese Black cattle. In the result of analysis of variance, g.841G>C showed stronger effects on fatty acid percentage than those of g.16024A>G in all populations. These results suggested that g.841G>C would be a responsible mutation for fatty acid composition and contribute to production of high-grade beef as a selection marker in beef cattle.

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“…FASN in cells mainly participates in the metabolic process of acidic materials such as fatty acid (12). Moreover, FASN has various enzymatic activities such as condensation, dehydration, and polymerization in plants.…”

Section: Discussionmentioning

confidence: 99%

MAPK/P53-mediated FASN expression in bone tumors

Jiang¹,

Yin²,

Wu³

et al. 2017

Oncology Letters

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The correlation between mitogen-activated protein kinase (MAPK)/P53 signaling-dependent fatty acid synthase (FASN) expression and bone tumors was examined in the present study. We established the SH081 bone tumor cell line, which was used to determine the expression of FASN and MAPK/P53 at the mRNA and protein levels in bone tumor cells and normal cells. Compared with the normal cells, the expression of MAPK/P53 and FASN mRNA was significantly elevated, whereas inhibition of MAPK/P53 decreased FASN expression. Similarly, the expression of FASN and MAPK/P53 proteins were significantly elevated in the bone tumor cells and treatment with the MAPK/P53 inhibitor decreased the expression of FASN. To determine the role of MAPK/P53 in cell proliferation, bone cancer cells were treated with MAPK/P53 inhibitor and the results showed a reduced proliferation rate. Thus, FASN promotes the development of bone tumors and MAPK/P53 signaling contributes to bone tumors by upregulating the expression of FASN.

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Genetic variation of FASN is associated with fatty acid composition of Hanwoo

Cited by 17 publications

References 28 publications

Genetic association of PLAG1,SCD,CYP7B1 and FASNSNPs and their effects on carcass weight, intramuscular fat and fatty acid composition in Hanwoo steers (Korean cattle)

Genetic association of PLAG1,SCD,CYP7B1 and FASNSNPs and their effects on carcass weight, intramuscular fat and fatty acid composition in Hanwoo steers (Korean cattle)

The g.841G>C SNP of FASN gene is associated with fatty acid composition in beef cattle

MAPK/P53-mediated FASN expression in bone tumors

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