Genetic variation of interleukin-1 receptor type 1 is associated with severity of COVID-19 disease

Wang, Renxi

doi:10.1016/j.jinf.2021.12.010

Cited by 16 publications

(12 citation statements)

References 12 publications

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“…3 , 4 MR study has been widely used to assess the causal link between an exposure and an outcome. [3][4][5][6][7] To assess the effect of COVID-19 on endometrial cancer, we performed the present two-sample MR study as followed.First, we extracted genetic instrumental variants (IVs) from COVID-19 GWAS. To date, the largest COVID-19 GWAS was reported by the COVID-19 Host Genetics Initiative in 2020.…”

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confidence: 99%

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Genetic variation associated with COVID-19 is also associated with endometrial cancer

Gao¹,

Xu²,

Zhu³

et al. 2022

Journal of Infection

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Genetic variation associated with COVID-19 is also associated with endometrial cancerDear editor, In this journal, Cai and colleagues described that uterine corpus endometrial carcinoma, esophageal carcinoma, kidney renal papillary cell carcinoma, lung adenocarcinoma, kidney chromophobe, and prostate adenocarcinoma were at the high risk of COVID-19 infection. 1 Recently, in this journal, Qiu and colleagues reported that the high expression of SARS-CoV-2 cell receptors might lead to higher COVID-19 infection rates in cancer patients. 2 However, it is still unclear whether COVID-19 infection is a risk factor for endometrial cancer.Mendelian randomization (MR) study, based on the principle that genetic variants are randomly allocated at meiosis, is independent of many factors that bias observational studies. 3 , 4 MR study has been widely used to assess the causal link between an exposure and an outcome. [3][4][5][6][7] To assess the effect of COVID-19 on endometrial cancer, we performed the present two-sample MR study as followed.First, we extracted genetic instrumental variants (IVs) from COVID-19 GWAS. To date, the largest COVID-19 GWAS was reported by the COVID-19 Host Genetics Initiative in 2020. 8 Primarily, this GWAS is to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic. The summary dataset of COVID-19 GWAS (14,134 cases and 1284,876 controls from European ancestry) is available in https://gwas.mrcieu. ac.uk/datasets/ebi-a-GCST010780 . We selected three independent genome-wide significant variants as COVID-19 genetic IVs using the following criteria 1 : p value ( < 5 × 10 −8 ) on COVID-19; 2 linkage disequilibrium (LD) (r 2 < 0.001) between SNPs 3 ; The F-statistics of all selected IVs (F-statistic > 10) were all above the threshold of weak instruments of F-statistic < 10. 9 The main characteristics of three selected COVID-19 genetic IVs are shown in Suppl. Table 1 .Second, we extracted three selected COVID-19 genetic IVs from endometrial cancer GWAS dataset. To date, the largest endome-

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confidence: 99%

“… 3 , 4 MR study has been widely used to assess the causal link between an exposure and an outcome. 3 , 4 , 5 , 6 , 7 To assess the effect of COVID-19 on endometrial cancer, we performed the present two-sample MR study as followed.…”

mentioning

confidence: 99%

Genetic variation associated with COVID-19 is also associated with endometrial cancer

Gao¹,

Xu²,

Zhu³

et al. 2022

Journal of Infection

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“…MR studies use genetic variants independent of many factors that bias observational studies in assessing the causal association of an exposure with an outcome 8–12 . Thus, the genetical effect of COVID‐19 on childhood intelligence, identified by our present MR study, is not related to the lack of a stimulating environment during the pandemic but to COVID‐19 infection.…”

Section: Discussionmentioning

confidence: 63%

“…Using genetic variants independent of many factors that bias observational studies, Mendelian randomization (MR) studies have many advantages in assessing the causal association between an exposure and an outcome. 8 , 9 , 10 , 11 , 12 , 13 Thus, we used a two‐sample MR study to identify the causal genetic link between COVID‐19 and childhood intelligence.…”

Section: Introductionmentioning

confidence: 99%

Mendelian randomization study on the causal effects of COVID‐19 on childhood intelligence

Zhu

Zhou

et al. 2022

Journal of Medical Virology

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Although individuals with coronavirus disease 2019 (COVID‐19) are known to be at increased risk for other conditions resulting from pathogenic changes (including metaplastic or anaplastic) in the lungs and other organs and organ systems, it is still unknown whether COVID‐19 affects childhood intelligence. The present two‐sample Mendelian randomization study aims to identify the genetic causal link between COVID‐19 and childhood intelligence. Four COVID‐19 genetic instrumental variants (IVs) were chosen from the largest genome‐wide association studies (GWAS) for COVID‐19 (hospitalized vs. population) (6406 cases and 902 088 controls of European ancestry). The largest childhood intelligence GWAS ( n = 12 441 individuals of European ancestry) was used to evaluate the effect of the identified COVID‐19‐associated genetic IVs on childhood intelligence. We found that as the genetic susceptibility to COVID‐19 increased, childhood intelligence followed a decreasing trend, according to mr_egger ( β = −0.156; p = 0.601; odds ratio [OR] = 0.856; 95% confidence interval [CI]: 0.522–1.405), simple mode ( β = −0.126; p = 0.240; OR = 0.882; 95% CI: 0.745–1.044), and weighted mode ( β = −0.121; p = 0.226; OR = 0.886; 95% CI: 0.758–1.036) analyses. This trend was further demonstrated by the weighted median ( β = −0.134; p = 0.031; OR = 0.875; 95% CI: 0.774–0.988) and the inverse variance weighted ( β = −0.152; p = 0.004; OR = 0.859; 95% CI: 0.776–0.952). Our analysis suggests a causal link between genetically increased COVID‐19 and decreased childhood intelligence. Thus, COVID‐19 may be a risk factor for declines in childhood intelligence.

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“…Mendelian randomization (MR) is a method using specific genetic variants as a natural experiment to evaluate the putative causal relations between a potential exposure factor and outcome factor (7)(8)(9). Thus, we used a two-sample MR study to identify the putative causal link between plasma omega-3 levels and low back pain.…”

Section: Introductionmentioning

confidence: 99%

Mendelian Randomization Study on the Putative Causal Effects of Omega-3 Fatty Acids on Low Back Pain

Zhou

Zhu

et al. 2022

Front. Nutr.

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Previous observational studies have suggested an important role of omega-3 in low back pain. In the present study, we used a two-sample Mendelian randomization (MR) study to identify the putative causal link between omega-3 and low back pain. A broadly used genome-wide association study (GWAS) (n = 8,866 individuals from European ancestry) was used to select plasma omega-3 genetic instrumental variables (IVs). A previously reported GWAS (4,863 cases and 74,589 controls from European ancestry) for low back pain were used to assess the effect of plasma omega-3 levels on low back pain. MR-egger_intercept, MR-PRESSO, MR_egger, and inverse variance weighted (IVW) in Cochran's Q-test were used to determine the pleiotropy and heterogeneity, respectively. MR-egger, weighted median, IVW, and weighted mode were used to perform MR analysis. Finally, the effect of a single nucleotide polymorphism (SNP) was used to test the SNP bias. We did not find a significant pleiotropy or heterogeneity of all six selected plasma omega-3 genetic IVs in low back pain GWAS. Expectedly, we found that as plasma omega-3 levels genetically increased, the risk of low back pain had a decreased trend using MR-egger (Beta = −0.593, p = 0.228; OR = 0.553) and weighted mode (Beta = −0.251, p = 0.281; OR = 0.778). This reduced trend was further proven by weighted median (Beta = −0.436, p = 0.025; OR = 0.646) and IVW (Beta = −0.366, p = 0.049; OR = 0.694). Our analysis suggested a putative causal link between genetically increased plasma omega-3 levels and the reduced risk of low back pain in European ancestries. Thus, the supplementation of omega-3 may be important for the prevention and treatment of low back pain.

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Genetic variation of interleukin-1 receptor type 1 is associated with severity of COVID-19 disease

Cited by 16 publications

References 12 publications

Genetic variation associated with COVID-19 is also associated with endometrial cancer

Genetic variation associated with COVID-19 is also associated with endometrial cancer

Mendelian randomization study on the causal effects of COVID‐19 on childhood intelligence

Mendelian Randomization Study on the Putative Causal Effects of Omega-3 Fatty Acids on Low Back Pain

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