Genetic variation of rs12918566 affects GRIN2A expression and is associated with spontaneous movement response during sevoflurane anesthesia induction

Abstract

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Targeted Sequencing of Cytokine-Induced PI3K-Related Genes in Ulcerative Colitis, Colorectal Cancer and Colitis-Associated Cancer

“…Stability is essential in the mRNA secondary structure because stable complexes may increase translation efficiency [ 47 ]. This finding was also supported by another studies that showed the presence of a non-damaging intronic variant had caused alteration in the mRNA secondary structure and stability, thus affecting the mRNA expression level in the brain tissue [ 48 ]. Moreover, results of additional studies also corroborated this assumption, where the mutant rs10889677 variant that had aberrant translation efficiency showed lower rates of T-cell proliferation, subsequently increasing susceptibility of the IBD and elevating the risk for developing cancers, such as breast, lung and nasopharyngeal [ 49 , 50 ].…”

Editorial: Neural circuits underlying general anesthetics mediated consciousness changes

“…Despite the revolutionary contribution of general anesthesia to the clinic, the precise mechanisms of how general anesthetics induce their pharmacological actions are not completely understood (Bao et al, 2023 ; Luo et al, 2023 ). There are subtypes of general anesthetics with structured diversity; therefore, although all general anesthetics work on the central nervous system to induce a comprehensive state that is mainly characterized by reversible loss of consciousness, they interact with many varied molecular targets, such as GABA A receptors, NMDA receptors and many ion channels (Chen et al, 2021 ; Zhang et al, 2023a , b ). In recent decades, the researches on general anesthetics have focused on searching for critical molecules that involved in general anesthesia (Platholi and Hemmings, 2022 ; Yi et al, 2023 ).…”