2008
DOI: 10.1080/01677060802337299
|View full text |Cite
|
Sign up to set email alerts
|

Genetic Variations inFTSJ1Influence Cognitive Ability in Young Males in the Chinese Han Population

Abstract: Human cognitive ability is a trait that is known to be significantly influenced by genetic factors. Previous linkage data provide evidence suggesting that gene FtsJ homolog 1 (Escherichia coli) is associated with mental retardation. The gene may have a relation to individual differences in cognitive ability because it is most critical for brain development. In the present research, three tag single-nucleotide polymorphism (SNPs) (rs2268954, rs2070991, and rs5905692) in FtsJ homolog 1 (E. coli) are selected and… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
10
0

Year Published

2012
2012
2021
2021

Publication Types

Select...
6
3

Relationship

0
9

Authors

Journals

citations
Cited by 15 publications
(10 citation statements)
references
References 24 publications
0
10
0
Order By: Relevance
“…Some of these mutations caused a major reduction in hFTSJ1 mRNA compared to normal levels. HFTSJ1 mutations were also found in other familial genetic studies linking mutated hFTSJ1 not only to NSXLMR, but also to impaired cognition (Gong et al, 2008;Takano et al, 2008).…”
Section: Sctrm7mentioning
confidence: 62%
“…Some of these mutations caused a major reduction in hFTSJ1 mRNA compared to normal levels. HFTSJ1 mutations were also found in other familial genetic studies linking mutated hFTSJ1 not only to NSXLMR, but also to impaired cognition (Gong et al, 2008;Takano et al, 2008).…”
Section: Sctrm7mentioning
confidence: 62%
“…Notably, defects in tRNA modification have emerged as the cause of diverse neurological and neurodevelopmental disorders, thereby highlighting the critical role of tRNA modification in human health and physiology (Angelova et al, 2018; Ramos & Fu, 2019). In particular, the brain appears to be sensitive to any perturbation in translation efficiency and fidelity brought about by defects in tRNA modifications, as evidenced from the numerous cognitive disorders linked to tRNA modification enzymes such as: the Elongator complex (Hawer et al, 2018; Kojic & Wainwright, 2016); ADAT3 (Alazami et al, 2013; El‐Hattab et al, 2016; Ramos, Han, et al, 2019); NSUN2 (Abbasi‐Moheb et al, 2012; Khan et al, 2012; Martinez et al, 2012); FTSJ1 (Dai et al, 2008; Freude et al, 2004; Froyen et al, 2007; Gong et al, 2008; Guy et al, 2015; Ramser et al, 2004; Takano et al, 2008); WDR4 (Chen et al, 2018; Shaheen et al, 2015; Trimouille et al, 2018); KEOPS complex (Braun et al, 2017); PUS3 (Abdelrahman, Al‐Shamsi, Ali, & Al‐Gazali, 2018; Shaheen, Han, et al, 2016); CTU2 (Shaheen, Al‐Salam, El‐Hattab, & Alkuraya, 2016; Shaheen, Mark, et al, 2019); TRMT10A (Gillis et al, 2014; Igoillo‐Esteve et al, 2013; Narayanan et al, 2015; Yew, McCreight, Colclough, Ellard, & Pearson, 2016; Zung et al, 2015); PUS7 (de Brouwer et al, 2018; Shaheen, Tasak, et al, 2019); and ALKBH8 (Monies, Vagbo, Al‐Owain, Alhomaidi, & Alkuraya, 2019).…”
mentioning
confidence: 99%
“…90 Nonsyndromic X-linked mental retardation and intellectual disability can be caused by mutations in FtsJ methyltransferase homolog 1 ( FTSJ 1), 55,91 an enzyme that methylates tRNAs.…”
Section: Brain Disease and Neuronal Behaviormentioning
confidence: 99%