Genetic variations in IL1A and IL1RN are associated with the risk of preeclampsia in Chinese Han population

Li, Jing; Liu, Mengchun; Zong, Jingfeng; Tan, Ping; Wang, Jingli; Wang, Xunfeng; Ye, Yuanhua; Liu, Shiguo; Liu, Xuemei

doi:10.1038/srep05250

Cited by 29 publications

(25 citation statements)

References 33 publications

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“…[12] Interestingly, increasing evidence has suggested that polymorphisms of inflammation-related genes may be associated with PE development, such as tumor necrosis factor-α, IL-10, and IL1A. [13,14] However, whether the genetic variations in IL-8 are associated with the risk of PE is poorly studied.…”

Section: Introductionmentioning

confidence: 99%

Association between higher expression of interleukin-8 (IL-8) and haplotype −353A/−251A/+678T of IL-8 gene with preeclampsia

et al. 2016

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Preeclampsia (PE) is a common pregnancy-specific disorder associated with significant maternal and fetal morbidity and mortality worldwide.The present study was performed to investigate the role of a CXC chemokine interleukin-8 (IL-8), in the pathogenesis of PE. IL-8 expression levels were assessed in placental and serum samples from 160 pregnant women with PE (N = 68 severe, 92 mild) and 140 healthy donors.Results from enzyme-linked immunosorbent assay showed that the concentration of serum IL-8 in PE patients (180.27 ± 5.81 ng/L) was significantly higher than that in healthy controls (41.57 ± 5.67 ng/L). Patients with severe PE had even higher serum IL-8 levels. Similar messenger RNA and protein expression patterns of IL-8 in placental tissues were confirmed by quantitative real-time polymerase chain reaction and immunohistochemical assay (N = 30 each in the mild PE, severe PE, and control groups). In addition, single nucleotide polymorphisms of IL-8 gene were detected with polymerase chain reaction-restricted fragment length polymorphism/SSP. The frequency of IL-8-251A allele was significantly higher than that in controls (58.4% vs 48.9%, P < 0.05). The occurrence frequency of haplotype −353A/−251A/+678T (AAT) in PE subjects was 27.2% as compared to 21.9% in the control participants (P < 0.05).Our study reveals that IL-8 expression is positively associated with the severity of PE. Presence of haplotype AAT in pregnant women appears to be a risk factor for PE.

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Section: Introductionmentioning

confidence: 99%

Association between higher expression of interleukin-8 (IL-8) and haplotype −353A/−251A/+678T of IL-8 gene with preeclampsia

et al. 2016

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“…(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). However, the association of these polymorphisms with several diseases in different populations is controversial (Table 2).…”

Section: Functional Predictionmentioning

confidence: 98%

The interleukin-1β-511 T>C (rs16944) gene polymorphism is associated with risk of developing silent myocardial ischemia in diabetic patients

et al. 2015

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“…As PE is a polygenetic hereditary disease and previous studies have been indicated that many cytokine genes are associated with susceptibility to it such as VEGF [35,36], NLRP1 [37], IL-1 [15,16], TNF-α [17,18], IFN-γ [19] and so on. Therefore in the present study we investigated whether IL-33 rs3939286 and IL-1RL1 rs13015714 play pivotal roles in the development of PE.…”

Section: Discussionmentioning

confidence: 99%

“…PE is a complex polygenetic hereditary disease involving both genetic and environmental factors [14] and previous studies have identified many candidate genes associated with susceptibility to it, such as IL-1 [15,16], TNF-α [17,18], IFN-γ [19] and so on. We therefore hypothesize that IL-33 and IL-1RL1 might play critical roles in pathophysiology of PE.…”

Section: Introductionmentioning

confidence: 99%

A Case-Control Study Indicates that no Association Exists Between Polymorphisms of IL-33 and IL-1RL1 and Preeclampsia

Ren¹,

Guo²,

Liu³

et al. 2016

Cell Physiol Biochem

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Background/Aims: Preeclampsia (PE) is a systemic inflammatory response syndrome involving varieties of cytokines, and previous studies have shown that IL-33 and its receptor IL-1RL1 play pivotal roles in the development of it. As a polygenetic hereditary disease, it is necessary to study the gene analysis for PE. Therefore, the present study was to determine whether IL-33 rs3939286 and IL-1RL1 rs13015714 associated with susceptibility to PE in Chinese Han women. Methods: 1,031 PE patients and 1,298 controls were enrolled and the genotyping for rs3939286 in IL-33 and rs13015714 in IL-1RL1 was performed by TaqMan allelic discrimination real-time PCR. Hardy-Weinberg equilibrium (HWE) was examined to ensure the group representativeness and Pearson's chi-square test was used to compare the differences in genetic distributions between the two groups. Results: No significant differences in genotypic and allelic frequencies of the two polymorphisms loci were observed between cases and controls. There were also no significant differences in genetic distributions between mild/severe and early/late-onset PE and control groups. Conclusion: Although our data suggested that the polymorphisms of IL-33 rs3939286 and IL-1RL1 rs13015714 might not be critical risk factors for PE in Chinese Han women, the results need to be validated in different nations.

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Genetic variations in IL1A and IL1RN are associated with the risk of preeclampsia in Chinese Han population

Cited by 29 publications

References 33 publications

Association between higher expression of interleukin-8 (IL-8) and haplotype −353A/−251A/+678T of IL-8 gene with preeclampsia

Association between higher expression of interleukin-8 (IL-8) and haplotype −353A/−251A/+678T of IL-8 gene with preeclampsia

The interleukin-1β-511 T>C (rs16944) gene polymorphism is associated with risk of developing silent myocardial ischemia in diabetic patients

A Case-Control Study Indicates that no Association Exists Between Polymorphisms of IL-33 and IL-1RL1 and Preeclampsia

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