Genetical control of the concentration of ME7 scrapie agent in the brain of mice

Dickinson, A. G.; Meikle, Veronica M. H.; Fraser, H.

doi:10.1016/0021-9975(69)90021-8

Cited by 105 publications

(52 citation statements)

References 6 publications

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“…into groups of 12 C57BL indicator mice. The scrapie titer in each spleen was determined from the mean incubation period in the assay mice by reference to established doseand incubation period-response curves for scrapie-infected spleen tissue (11).…”

Section: Methodsmentioning

confidence: 99%

Follicular Dendritic Cell Dedifferentiation by Treatment with an Inhibitor of the Lymphotoxin Pathway Dramatically Reduces Scrapie Susceptibility

Mabbott

Young

McConnell

et al. 2003

J Virol

141

178

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Section: Methodsmentioning

confidence: 99%

Follicular Dendritic Cell Dedifferentiation by Treatment with an Inhibitor of the Lymphotoxin Pathway Dramatically Reduces Scrapie Susceptibility

Mabbott

Young

McConnell

et al. 2003

J Virol

141

178

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“…Titrations were carried out in C57BL and Rill mice, using the i.c. injection route to establish whether differences in incubation period with different strains of mice are due to intrinsic differences in infectability and also to provide a dose-response curve for subsequent indirect estimates of infectivity with single dilutions (Dickinson et al, 1969).…”

Section: Sources Ofscrapie/bse Infection the Bse Sources Were Brainsmentioning

confidence: 99%

Transmission of bovine spongiform encephalopathy and scrapie to mice

Fraser

Bruce²,

Chree³

et al. 1992

Journal of General Virology

Self Cite

180

133

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Transmission from four cases of bovine spongiform encephalopathy (BSE) to mice resulted in neurological disease in 100% of recipient animals, after incubation periods of between 265 and 700 days post-injection. The results from the four cases were very similar to one another. There were major differences in the incubation period between the four inbred strains of mice tested, and even between strains of the same Sinc genotype, and the incubation periods of Sinc heterozygote mice were much longer than those for any of the inbred strains. Transmission from a case of natural scrapie differed in two important respects: there were no differences in the incubation period between mouse strains of the same Sinc genotype, and that of the heterozygotes was between those of the Sinc homozygotic parental strains. The distribution of vacuolar degeneration in the brains of mice infected with scrapie also differed from those infected with the BSE isolates. Transmission was also achieved from formol-fixed BSE brain. These results show that the same strain of agent caused disease in the BSE cases, and that the relationship of BSE to scrapie in sheep is unclear.

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“…For TSEs, the brain is the major area of histopathological damage and is the organ that has the highest level of infectious titres (Eklund et al, 1965 ;Dickinson et al, 1969 ;Fraser, 1979 ;Dickinson & Fraser, 1979). Analyses of the interaction between TSE agents and host is accomplished most effectively using the archetype of these diseases, scrapie.…”

Section: Introductionmentioning

confidence: 99%

Scrapie strain-specific interactions with endogenous murine leukaemia virus.

Carp¹,

Meeker²,

Caruso³

et al. 1999

Journal of General Virology

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The finding that a senescence-accelerated mouse (SAMP8) shows early brain ageing, with histopathological changes resembling those seen in scrapie, combined with the discovery of high levels of endogenous murine leukaemia virus (MuLV) in brains of SAMP8 mice prompted us to examine the effect of scrapie infection on MuLV titres in this strain and in one of its progenitors, the AKR strain. Three scrapie strains (ME7, 22L and 139A) that had a comparatively short incubation period in SAMP8 and AKR mice caused an increase in brain MuLV titres that was scrapie strainspecific : in each mouse strain, the greatest effect was with 139A, and the least with ME7. The 22A scrapie strain, which has a long incubation period in SAMP8 mice, did not affect MuLV titres in brains of this mouse strain. Previous analyses of scrapie incubation periods in AKR, SAMP8 and another strain derived from an AKR cross (SAMR1) showed an inverse relationship between brain MuLV titres and scrapie incubation periods. This finding, combined with the effect of scrapie on MuLV titres, suggests an interaction between the scrapie infectious process and MuLV replication.

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Genetical control of the concentration of ME7 scrapie agent in the brain of mice

Cited by 105 publications

References 6 publications

Follicular Dendritic Cell Dedifferentiation by Treatment with an Inhibitor of the Lymphotoxin Pathway Dramatically Reduces Scrapie Susceptibility

Follicular Dendritic Cell Dedifferentiation by Treatment with an Inhibitor of the Lymphotoxin Pathway Dramatically Reduces Scrapie Susceptibility

Transmission of bovine spongiform encephalopathy and scrapie to mice

Scrapie strain-specific interactions with endogenous murine leukaemia virus.

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