Genetical Implications of the Structure of Deoxyribonucleic Acid

Watson, James D.; Crick, Francis

doi:10.1038/171964b0

Cited by 2,122 publications

(764 citation statements)

References 4 publications

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“…Since the double-helical structure of B-DNA was recognised in the 1950s, 3 On a separate file. On a separate file On a separate file On a separate file On a separate file On a separate file and increasing metal complex (0 -50 μM) concentration.…”

Section: Discussionmentioning

confidence: 99%

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Synthetic metallomolecules as agents for the control of DNA structure

2007

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DNA is often referred to as the molecule of life, since it contains the instructions for making the required proteins. However, it is not simply a (genetic) code to be read; its structure has an important role in determining when and how much of a particular 5 protein is made at any point in time. Furthermore, there are a range of special DNA structures, e.g. Holliday junctions, which play essential roles for the existence of life as we know it or as it will become. In this tutorial review the normal B-DNA structure is summarised and metallomolecule binding modes discussed then used as a basis for examining DNA structures which can be induced by molecules containing metallic cations. The effects of aquated metal ions, cobalt ammine and ruthenium octahedral metal complexes, metallo helicates and platinum complexes such as cis-platin are discussed alongside techniques such as NMR, 10 X-ray crystallography, gel electrophoresis, circular dichroism, linear dichroism and molecular dynamics.

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Section: Discussionmentioning

confidence: 99%

“…3 Furthermore, the normal pairings of bases are adenine with thymine and 35 guanine with cytosine. The pairs of bases, being planar, can be stacked one above the other.…”

Section: Introduction To Dnamentioning

confidence: 99%

Synthetic metallomolecules as agents for the control of DNA structure

2007

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“…5). In view of the many uncertainties that attend their determination and the probable presence of precipitates on the fibers, caused by the fixative, these values do not appear too far removed from the 20 A which is the diameter of a double helix of DNA in the Watson-Crick model (18). In presenting this argument we have been following Kellenberger and his collaborators (7,8,17) who, having observed the high density of the DNA-filled heads of bacteriophages in sections of infected bacteria, regard the dense fibrous material in the nucleoplasms as DNA not combined with a protein partner.…”

Section: Discussionmentioning

confidence: 99%

“…In the nuclei of one of the two bacteria this is seen at all times, in the nuclei of the other one only at the beginning of the growth cycle. In some places the diameter of the nuclear fibers is close to that of the DNA molecule in the model of Watson and Crick (1953). …”

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confidence: 99%

Observations With the Electron Microscope on the Fine Structure of the Nuclei of Two Spherical Bacteria

Iterson

Robinow

1961

The Journal of Cell Biology

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The nuclei of two spherical bacteria have been examined in electron micrographs of thin sections of specimens prepared by the method of Ryter and Kellenberger (1958). The nuclei appear to consist of the same fine fibers in a matrix of low density which have already been seen in many other bacteria prepared by the same procedure. They are worth a separate description because their constituent fibers are arranged in patterns of uncommon orderliness. In the nuclei of one of the two bacteria this is seen at all times, in the nuclei of the other one only at the beginning of the growth cycle. In some places the diameter of the nuclear fibers is close to that of the DNA molecule in the model of Watson and Crick (1953).

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“…Such a mechanism of spontaneous mutations (transitions) was proposed by Watson and Crick in 1953 (1) and has been repeatedly discussed since then. Topal and Fresco (2) applied this mechanism to transversions suggesting that they are induced by the formation of purinepurine pairs.…”

Section: Introductionmentioning

confidence: 99%

Possible conformations of double-helical polynucleotides containing incorrect base pairs

Chuprina

Poltev

1983

Nucl Acids Res

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Theoretical conformational analysis using classical potential functions has shown the possibility of incorporation of nucleotide mispairs with the bases in normal tautcmeric forms into the DNA double helix. Incorrect purinepyrimidine, purine-purine and pyrimidine-pyrimidine pairs can be incorporated into the double helix existing both in A-and B-conformations. The most energy favourable conformations of fragments containing a mispair have all the dihedral angles of the sugar-phosphate backbone within the limits characteristic of double helices consisting of Watson-Crick nucleotide pairs. Incorporation of mispairs is possible practically without the appearance of reduced interatomic contacts. Mutual position of bases in the incorporated mispair does not differ much from their position at the energy minimum of the corresponding isolated base pairs. Conformational parameters of irregular regions of double-stranded polynucleotides containing G:U,

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Genetical Implications of the Structure of Deoxyribonucleic Acid

Cited by 2,122 publications

References 4 publications

Synthetic metallomolecules as agents for the control of DNA structure

Synthetic metallomolecules as agents for the control of DNA structure

Observations With the Electron Microscope on the Fine Structure of the Nuclei of Two Spherical Bacteria

Possible conformations of double-helical polynucleotides containing incorrect base pairs

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