Genetically determined cutaneous nevi and risk of cancer

Dusingize, Jean Claude; Law, Matthew; Pandeya, Nirmala; Ong, Jue‐Sheng; MacGregor, Stuart; Whiteman, David C.; Olsen, Catherine M.

doi:10.1002/ijc.33874

Intl Journal of Cancer

2021

DOI: 10.1002/ijc.33874

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Genetically determined cutaneous nevi and risk of cancer

Jean Claude Dusingize

Matthew Law

Nirmala Pandeya

et al.

Abstract: Numerous epidemiologic studies have reported positive associations between higher nevus counts and internal cancers. Whether this association represents a true relationship or is due to bias or confounding by factors associated with both nevus counts and cancer remains unclear. We used germline genetic variants for nevus count to test whether this phenotypic trait is a risk-marker for cancer. We calculated polygenic risk scores (PRS) for nevus counts using individual-level data in the UK Biobank (n = 394 306) … Show more

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Cited by 2 publications

References 42 publications

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A genetically informed study reveals modifiable pathways in skin cancer

Qian,

Gong,

et al. 2024

J Transl Med

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Background Identifying modifiable risk factors is essential for the prevention of skin cancer; however, establishing causality can be challenging in conventional epidemiological studies. This study aimed to determine the causal associations of potentially modifiable risk factors with skin cancer using Mendelian randomization (MR). Methods Genetic instruments for 53 risk factors, including socioeconomic status, dietary and lifestyle factors, anthropometric measures, medication use, and comorbidities, were identified from previous genome-wide association studies. Two-sample MR analyses were performed using summary statistics for three major types of skin cancer: melanoma, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). Findings were verified using multiple MR methods under different assumptions and replication datasets. Results Genetic liability to sunburn occasions, actinic keratosis, and prior skin cancers was associated with a higher risk of all three types of skin cancer, whereas genetic liability to vitiligo was associated with a lower risk. For specific skin cancer types, genetically predicted higher nevus counts and occupational class were associated with an increased risk of melanoma. Genetic liability to rheumatoid arthritis, type 2 diabetes, and increased physical activity were associated with a lower risk of BCC. Genetically predicated body mass index showed a negative association with BCC, and a positive association with SCC. Conclusions Our study reaffirmed several previously established risk factors and identified novel potential risk factors for skin cancer. Further work is needed to unravel the biological pathways in different skin cancer types and translate our findings to inform public health policies. Supplementary Information The online version contains supplementary material available at 10.1186/s12967-024-05719-1.

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A genetically informed study reveals modifiable pathways in skin cancer

Qian,

Gong,

et al. 2024

J Transl Med

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Discriminant models of the possibility of benign nevi occurrence and features in men depending on the characteristics of anthropo-somatotypological indicators

et al. 2022

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The multifactorial nature of the origin and development of nevi is the subject of debate so far. One way to understand this process and get an answer to this question is to use a constitutional method of research. The purpose of the study is to build and analyze discriminant models of benign nevi occurrence possibility in men depending on the characteristics of the structure and size of the body. For Ukrainian men aged 22 to 35 years with benign nevi (34 with melanocyte benign simple nevi; 27 with melanocyte benign dysplastic nevi; 14 with melanocyte benign congenital nevi; 17 with nonmelanocyte benign nevus) determined anthropometric indicators according to the scheme of Bunak V. V. (1941), components of the somatotype according to the Heath-Carter scheme (1990), as well as indicators of the component composition of body weight according to Matejko formulas (1921). The control group consisted of anthropometric and somatotypological indicators of 82 practically healthy men of the same age group selected from the data bank of the Research Center of National Pirogov Memorial Medical University, Vinnytsya. Discriminant analysis was performed in the licensed statistical package “Statistica 5.5”. With the help of discriminant analysis, reliable models of the possibility of benign nevi depending on the characteristics of anthropometric and somatotypological indicators are built. It was found that healthy and patients with benign nevi of men can reliably interpret the obtained classification indicators between healthy and sick, and between patients with melanocyte simple or dysplastic nevi and other groups of benign nevi (discriminant function covers 75.7 % of cases; Wilks' Lambda statistics=0.125; р<0.001). Between groups of benign nevi, reliable interpretation of the obtained classification indicators is possible only between patients with melanocyte simple or dysplastic nevi and melanocyte congenital or non-melanocyte nevi (discriminant function covers 48.4 % of cases; Wilks' Lambda statistics=0.662; р<0.001), however, the totality of all anthropological variables has little discrimination. The models of healthy and sick men include the skinfold thickness (42.8 %), girth sizes (28.6 %), shoulder width and endomorphic component of the somatotype (14.3 % each); and among men with benign nevi, only girth sizes of the body. The greatest contribution to discrimination in models of healthy and sick men is made by the circumference of the forearm at the top, the width of the shoulders and the skinfold thickness on the side; and among patients with benign nevi – chest girth on inspiration. The obtained results indicate a significant influence of environmental factors on the occurrence of benign nevi.

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Genetically determined cutaneous nevi and risk of cancer

Cited by 2 publications

References 42 publications

A genetically informed study reveals modifiable pathways in skin cancer

A genetically informed study reveals modifiable pathways in skin cancer

Discriminant models of the possibility of benign nevi occurrence and features in men depending on the characteristics of anthropo-somatotypological indicators

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