Genetically elevated gamma-glutamyltransferase and Alzheimer's disease

Kunutsor, Setor K; Laukkanen, Jari A.; Burgess, Stephen

doi:10.1016/j.exger.2018.03.001

Cited by 5 publications

(6 citation statements)

References 32 publications

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“…A study of GGT and Parkinson's disease is also consistent with our finding, that GGT may contribute to neurodegenerative disease in the female population (Yoo et al, 2020 ). However, contrary to our findings, a genetic study found no clear link between GGT and cognitive function (Kunutsor et al, 2018 ), possibly because that study did not include a subgroup analysis based on sex, which is essential because of the finding from previous study that estrogen may affect GGT activity in the body (Zarida et al, 1994 ).…”

Section: Discussioncontrasting

confidence: 99%

“…Since we performed a cross-sectional study, we could not refute the conclusion reached in previous studies that there is no causal link between GGT and MCI (Kunutsor et al, 2018 ). However, there has been no previous research into the relationship between GGT and cognitive function in the female population, so our results are significant in terms of the diagnosis and early indication of MCI in the female population.…”

Section: Limitationsmentioning

confidence: 74%

“…Another longitudinal study of older adults also showed that increased GGT levels are associated with cognitive decline at the end of life (Praetorius Bjork and Johansson, 2018 ). However, the result of a population-wide genetic study could not confirm a causal effect of GGT on the risk of dementia (Kunutsor et al, 2018 ). Therefore, the relationship between GGT and cognitive impairment is far from clear, especially among female individuals, among whom there is a lack of related research.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Gamma-Glutamyl Transferase and Mild Cognitive Impairment in Chinese Women

Tang

Chen

Zhang

et al. 2021

Front. Aging Neurosci.

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Background: Dementia, as a global public health problem, is becoming increasingly serious. As a precursor of dementia, mild cognitive impairment (MCI) plays an important role in the diagnosis and prevention of dementia. Recent studies have found a correlation between gamma-glutamyl transferase (GGT) levels and cognitive function in men. The relationship between GGT levels and cognitive function in women remains unclear because GGT activity and expression differ between the sexes.Method: We recruited a total of 2,943 Chinese women from Jidong and Taian in 2019. We grouped the participants according to GGT levels, diagnosed MCI using the Montreal Cognitive Assessment (MOCA) scale, and modeled the study outcomes using logistic regression to explore the relationship between GGT level and MCI. We also analyzed the interaction of obesity, sleep duration, and hyperuricemia with GGT in the development of MCI.Results: The prevalence of MCI increased with increasing GGT level, from the lowest quartile to the highest quartile of GGT: 8.4% (66/786), 14.2% (119/840), 17.6% (108/613), and 21.4% (151/704), respectively. At the same time, as GGT levels increased, so did the risk of MCI. In the fully adjusted model, compared with those for participants in the lowest GGT quartiles, the odds ratios (ORs), and 95% confidence intervals (CIs) for MCI for participants in the second, third, and fourth GGT quartiles were 1.49 (1.04–2.12), 1.53(1.06–2.21), and 1.88 (1.33–2.65), respectively. The risk of developing MCI was further increased in people with high GGT levels who were obese (OR = 1.96, 95% CI: 1.39–2.76, P < 0.001), slept less (OR = 1.91, 95% CI: 1.35–2.71, P < 0.001), had high levels of uric acid (OR = 1.55, 95% CI: 1.03–2.32, P < 0.001), or after menopause (OR = 2.92, 95% CI: 2.07–4.12, P < 0.001).Conclusion: We found that MCI is more common in women with elevated GGT levels, so GGT could be a potential diagnostic marker for MCI. Meanwhile, our findings indicated that women with high GGT levels had an increased risk of MCI when they were obese, sleep deprived, had high serum uric acid (SUA) levels or underwent menopause.

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Section: Discussioncontrasting

confidence: 99%

Section: Limitationsmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

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Association Between Gamma-Glutamyl Transferase and Mild Cognitive Impairment in Chinese Women

Tang

Chen

Zhang

et al. 2021

Front. Aging Neurosci.

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“…The risk was highest in the group with a high baseline GGT level and highest GGT variability (27.3%) [73] . Consistently, another recent study conducted on 2943 Chinese women showed that the prevalence of mild cognitive impairment increased from 8.4% among women in the first GGT tertile to 21.4% among women in the fourth GGT quartile with a higher prevalence in the presence of obesity, sleep deprivation, hyperuricemia, or menopause [74] .…”

Section: Ggt Neurodegenerative Disorders and Dementiasupporting

confidence: 67%

Concise review: gamma-glutamyl transferase - evolution from an indiscriminate liver test to a biomarker of cardiometabolic risk

Lonardo¹,

Ndrepepa²

2022

Metab Target Organ Damage

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This concise review article critically examines the recent medical literature regarding gamma glutamyl transferase (GGT) with a special emphasis on newly proposed indications for GGT use, including cardiovascular risk assessment. GGT is a ubiquitous glycosylated protein embedded in the outer surface of cell membranes, which catalyzes the transfer of glutamyl groups from various substrates and plays a key role in the antioxidant/pro-oxidant balance. In the past, the enzyme was considered a non-specific liver test. Current evidence supports the role of GGT in the assessment of portal hypertension in cystic fibrosis, porto-sinusoidal vascular disease, malignant mesothelioma, and incident type 2 diabetes and as a biomarker of cardiometabolic risk and cardiovascular disease. Several specific points including the use of GGT in hepatology as a sensitive but poorly specific test and the association of GGT with metabolic syndrome, nonalcoholic fatty liver disease and its fibrotic stages, cardiometabolic risk, chronic kidney disease, neurodegenerative disorders and dementia, idiopathic pulmonary arterial hypertension, and Corona Virus Disease 2019 (COVID-19) are addressed based on the most recent research in these fields. Putative mechanisms linking GGT with increased metabolic stress and the effects of various therapeutic interventions on GGT values are also discussed. We conclude that GGT has evolved from an indiscriminate liver test and an index of alcohol consumption to a biomarker of cardiometabolic health. The proper interpretation of GGT values (i.e., of hepatic vs. extrahepatic origin) is deeply affected by the clinical and epidemiological context. We propose that GGT may be utilized in public health campaigns, in the research arena, and in clinical practice to identify those individuals who can benefit most from the proactive preventive and therapeutic approaches, given that they are at high cardiometabolic risk.

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“…Gamma Glutamyl Transferase merupakan penanda cedera hati dan konsumsi alkohol yang berlebihan (Kunutsor et al, 2018). Pemeriksaan GGT seringkali diukur bersamaan dengan pemeriksaan enzim lainnya seperti ALP, jika kadar GGT atau ALP meningkat, diduga terjadi gangguan pada hati ataupun saluran empedu (Rosida, Berdasarkan Tabel 3 diperoleh aktivitas GGT meningkat pada pemain game online sebanyak 57,1% (4 orang) dengan rerata kadar GGT yaitu 25,4 ± 23,4 berdasarkan usia 19-22 tahun.…”

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Review: Gambaran Aktivitas Enzim Gamma Glutamyl Transferase (GGT) pada Pemain Game Online di Kecamatan Jekan Raya

Ermanita¹,

Handayani²,

Muharamah³

et al. 2020

Borneo J Med Lab Tech

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The online game is games that used an internet connection that can make players ignore sleep time. Changed sleep patterns can change circadian rhythms that cause oxidative stress which can attack liver cells. The purpose of this study was to determine the description of the activity of the enzyme Gamma Glutamyl Transferase (GGT) in Online Game players in Jekan Raya sub-district. This research was conducted by descriptive method. Population is the total of the objects that will be researched according to the characteristics desired in the study. Samples are parts that can represent the population to be used as research objects. Samples obtained in this study amounted to 50 people. The results of examination of GGT levels for online game players based on age characteristics 34.8 ± 32.3 U/L, 32.6 ± 27.1 U/L based on the characteristics of sleep duration, 28.5 ± 28.4 U/L based on the characteristics of duration playing games, 32.9 ± 28.8 U/L based on smoking activity characteristics, 42.5 ± 36.1 U/L based on blood pressure characteristics, and 29.5 ± 28.5 U/L based on body mass index characteristics (BMI). From the results of the examination of the activity of the enzyme Gamma Glutamyl Transferase (GGT) that was carried out in 50 samples there was an increase of 7 samples.

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Genetically elevated gamma-glutamyltransferase and Alzheimer's disease

Cited by 5 publications

References 32 publications

Association Between Gamma-Glutamyl Transferase and Mild Cognitive Impairment in Chinese Women

Association Between Gamma-Glutamyl Transferase and Mild Cognitive Impairment in Chinese Women

Concise review: gamma-glutamyl transferase - evolution from an indiscriminate liver test to a biomarker of cardiometabolic risk

Review: Gambaran Aktivitas Enzim Gamma Glutamyl Transferase (GGT) pada Pemain Game Online di Kecamatan Jekan Raya

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