Genetically Engineered Animal Models in Toxicologic Research

Himmel, Lauren E.; Wilson, Kristin Lewis; Santagostino, Sara Francesca; Bolon, Brad

doi:10.1016/b978-0-12-821044-4.00024-8

Cited by 1 publication

(1 citation statement)

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“…Biopharming has been gaining much more attention in the last few decades. Biopharming is the production and use of transgenic animals and plants to produce pharmaceutical substances for use in animals and humans [ 1 ]. Advancements in biopharming have laid a foundation to produce phenotypes such as genetically resistant chickens to meet the global protein consumption demand.…”

Section: Introductionmentioning

confidence: 99%

Formation, Application, and Significance of Chicken Primordial Germ Cells: A Review

Mathan

Zaib

Jin

et al. 2023

Animals

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Chicken is one of the most widely consumed sources of protein globally. Primordial germ cells (PGCs) are the precursors for ova and sperm. One of the early embryogenesis events in most animals is the segregation of the somatic and germ lineages. PGC cultures occur in the germline, and PGCs are less studied in many species. It is relatively challenging to separate, cultivate, and genetically alter chicken without mutating the basic germline. The present study aims to gather previous research about chicken PGCs and provide a customized review of studies and developments in the field of PGCs, especially for avian species. Furthermore, we show that the propagation of chicken PGCs into embryonic germ cells that contribute to somatic tissues may be produced in vitro. Primordial germ cells offer an ideal system in developmental biology, as these cells play a vital role in the genetic modification and treatment of infertility. Cryopreservation helps to maintain genetic resources and sustainable production in the poultry industry. Keeping in mind the significance of cryopreservation for storage and gametogenesis, we discuss its role in the preservation of primordial germ cells. Transgenesis and genetic modifications in chicken lead to the development of various medicinal chicken varieties and aid in improving their production and quality for consumption purposes. Additionally, these characteristics open up new possibilities for modifying the chicken genome for agricultural and medical purposes.

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Section: Introductionmentioning

confidence: 99%