Genetically Engineered Cellular Nanovesicle as Targeted DNase I Delivery System for the Clearance of Neutrophil Extracellular Traps in Acute Lung Injury

Du, Yang; Chen, Yining; Li, Fangyuan; Mao, Zhengwei; Ding, Yuan; Wang, Weilin

doi:10.1002/advs.202303053

Cited by 13 publications

(1 citation statement)

References 55 publications

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“…Du et al (54) have successfully developed a novel biomimetic DNase I delivery system called DCNV (genetically and bio-orthogonally engineered cell-derived nanovesicles). This innovative system demonstrates high efficiency in targeting the lungs during LPS-induced acute lung injury and effectively clears pulmonary NETs.…”

Section: Sepsis-associated Ali/ardsmentioning

confidence: 99%

Neutrophil extracellular traps and their implications in airway inflammatory diseases

Xuan,

Zhao,

Kang

et al. 2024

Front. Med.

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Neutrophil extracellular traps (NETs) are essential for immune defense and have been increasingly recognized for their role in infection and inflammation. In the context of airway inflammatory diseases, there is growing evidence suggesting the involvement and significance of NETs. This review aims to provide an overview of the formation mechanisms and components of NETs and their impact on various airway inflammatory diseases, including acute lung injury/ARDS, asthma, chronic obstructive pulmonary disease (COPD) and cystic fibrosis. By understanding the role of NETs in airway inflammation, we can gain valuable insights into the underlying pathogenesis of these diseases and identify potential targets for future therapeutic strategies that either target NETs formation or modulate their harmful effects. Further research is warranted to elucidate the complex interactions between NETs and airway inflammation and to develop targeted therapies that can effectively mitigate their detrimental effects while preserving their beneficial functions in host defense.

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Section: Sepsis-associated Ali/ardsmentioning

confidence: 99%

Neutrophil extracellular traps and their implications in airway inflammatory diseases

Xuan,

Zhao,

Kang

et al. 2024

Front. Med.

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A Genetically Engineered Biomimetic Nanodecoy for the Treatment of Liver Fibrosis

Du,

Ding,

Chen

et al. 2024

Advanced Science

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Liver fibrosis, arising from factors such as viral infections or metabolic disorders, represents an ongoing global health challenge and is a major risk factor for hepatocellular carcinoma. Unfortunately, there are no clinically approved drugs available for its treatment. Recent studies have illuminated the pivotal role of macrophage recruitment in the pathogenesis of liver fibrosis, presenting a potential therapeutic target. Therefore, it holds great promise to develop novel anti‐fibrotic therapies capable of inhibiting this process. Herein, a drug‐loaded biomimetic nanodecoy (CNV‐C) is developed by harnessing genetically engineered cellular vesicles for the treatment of liver fibrosis. CNV‐C is equipped with a C‐C motif chemokine receptor 2 (CCR2)‐overexpressed surface, enabling it to selectively neutralize elevated levels of C‐C motif chemokine ligand 2 (CCL2), thereby reducing macrophage infiltration and the subsequent production of the fibrogenic cytokine transforming growth factor β (TGF‐β). Moreover, curcumin, an anti‐fibrotic agent, is loaded into CNV‐C and delivered to the liver, facilitating its efficacy in suppressing the activation of hepatic stellate cells by blocking the downstream TGF‐β/Smad signaling. This combinational therapy ultimately culminates in the alleviation of liver fibrosis in a mouse model induced by carbon tetrachloride. Collectively, the findings provide groundbreaking proof‐of‐concept for employing genetically modified nanodecoys to manage liver fibrosis, which may usher in a new era of anti‐fibrotic treatments.

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Hydrogen-releasing magnesium hydrogel mitigates post laminectomy epidural fibrosis through inhibition of neutrophil extracellular traps

Mei,

Sun,

Cao

et al. 2024

Acta Biomaterialia

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Genetically Engineered Cellular Nanovesicle as Targeted DNase I Delivery System for the Clearance of Neutrophil Extracellular Traps in Acute Lung Injury

Cited by 13 publications

References 55 publications

Neutrophil extracellular traps and their implications in airway inflammatory diseases

Neutrophil extracellular traps and their implications in airway inflammatory diseases

A Genetically Engineered Biomimetic Nanodecoy for the Treatment of Liver Fibrosis

Hydrogen-releasing magnesium hydrogel mitigates post laminectomy epidural fibrosis through inhibition of neutrophil extracellular traps

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