Genetically proxied intestinal microbiota and risk of erectile dysfunction

Abstract

BackgroundThe interaction between intestinal microbiota and erectile dysfunction (ED) is less investigated. This study was performed to explore the association between intestinal microbiota and ED.MethodsIn this two‐sample Mendelian randomization (MR) study, genetic variants of gut microbiota were obtained from MiBioGen consortium containing 18,340 individuals. Six methods including inverse variance weighting (IVW), MR‐Egger, weighted median, maximum likelihood, MR robust adjusted profile score, and MR pleiotropy residual sum and outlier were used to investigate the causal links between intestinal microbiota and ED. Furthermore, reverse MR analysis was performed to exclude the causal impact of ED on gut microbiota.ResultsAs revealed by the IVW estimator, the risks of ED were raised by genetically proxied Lachnospiraceae (OR: 1.27), Lachnospiraceae NC2004 group (OR: 1.17), Oscillibacter (OR: 1.20), Senegalimassilia (OR: 1.32) (All P < 0.05) and Tyzzerella‐3 (OR: 1.14, P < 0.05). It was observed that Ruminococcaceae UCG013 exerted protective effect against ED (OR: 0.77, P < 0.05). These results were consistent with other estimators in sensitivity analyses. In reverse MR analyses, genetic liability to ED did not alter the abundances of Lachnospiraceae, Lachnospiraceae NC2004 group, Oscillibacter, Senegalimassilia, Tyzzerella‐3, and Ruminococcaceae UCG013 (All P > 0.05). No heterogeneity and pleiotropy were detected by Cochran's Q‐test, MR‐Egger, and global test (All P > 0.05).ConclusionsThis study provided novel evidence that genetically proxied Lachnospiraceae, Lachnospiraceae NC2004 group, Oscillibacter, Senegalimassilia, Tyzzerella‐3, and Ruminococcaceae UCG013 had potentially causal effects on ED. Further studies are needed to clarify the biological mechanisms linking intestinal microbiota to ED.

Changing Trends in the Penile Prothesis Implantation of male with refractory Erectile Dysfunction in China

“…The main etiology of PPI was vasculogenic tower (51.8%), diabetes (18.8%) and pelvic trauma /spinal cord injury (12.5%) in China. 11,12 Despite the data above shows that high cost and relatively low patient acceptance have limited the use of PPI in China, among patients with refractory ED in China, those in need of young and middle-aged patients are more likely to accept, in order to maintain marriage, family stability, and sexual partner relationship.…”

Agaricus blazei Polysaccharide Alleviates DSS-Induced Colitis in Mice by Modulating Intestinal Barrier and Remodeling Metabolism

“…Oscillibacter is able to maintain gut pH balance by producing substances such as propionate and butyrate, thus promoting the health and stability of the intestinal mucosa [63,64]. Therefore, these two types of bacteria are generally considered beneficial, but their imbalance or depletion has been closely associated with inflammatory bowel disease, obesity, and other related conditions [65]. The results of the present study showed that the relative abundance of Lactobacillus and Shigella was significantly increased in DSS-induced UC, which is also consistent with the findings of Schirmer M [66].…”