Genetics and delusional disorder

Cardno, Alastair G.; McGuffin, Peter

doi:10.1002/bsl.681

Cited by 16 publications

(10 citation statements)

References 35 publications

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“…This finding is compatible with the findings of Kendler and Hays [20], according to which the prevalence of schizophrenia in relatives of DD patients was significantly lower than that found in relatives of patients with schizophrenia. Research on the topic, however, is still very rare, so we can agree with Cardno and McGuffin [21] who, overviewing the genetic research of DDs, concluded that it is not clear whether there is a genetic contribution to the etiology of DD.…”

Section: Introductionmentioning

confidence: 50%

The Clinical and Sociodemographic Profile of Persistent Delusional Disorder

Wustmann¹,

Pillmann²,

Friedemann³

et al. 2012

Psychopathology

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Section: Introductionmentioning

confidence: 50%

The Clinical and Sociodemographic Profile of Persistent Delusional Disorder

Wustmann¹,

Pillmann²,

Friedemann³

et al. 2012

Psychopathology

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“…A Swedish twin registry study [Prescott et al, 2007] ed heritability for psychotic disorder as 41% (CI 11-90%) in males and 67% (CI 53-82%) in females, with a caveat that the registry contained a notable proportion of twins of unknown zygosity who had a relatively high risk of psychotic disorder. Although the relative contributions of genetic and environmental influences to depressive psychosis, unspecified functional psychosis and delusional disorder are unclear [Cardno et al, 1999b;Cardno and McGuffin, 2006], their inclusion within the broad phenotype of psychotic disorder did not appear to reduce heritability compared with categories such as schizophrenia and bipolar disorder. This may be because such disorders are relatively uncommon, they may have substantial heritabilities that have not yet been substantiated, and/or they may have substantive overlap of genetic risk factors with other psychoses.…”

Section: Discussion Psychotic Disordermentioning

confidence: 89%

“…Two theoretical situations could provide arguments against this: 1. if one or more psychotic syndromes are not influenced by genetic factors, and 2. if two or more psychotic syndromes are genetically distinct. Although at present no psychotic syndromes clearly do not have a genetic basis, the evidence regarding some is unclear, as discussed above [Cardno et al, 1999b;Cardno and McGuffin, 2006]. In terms of genetic distinctness, most psychotic syndromes probably share some genetic influences in common [Kendler et al, 1995].…”

Section: Discussion Psychotic Disordermentioning

confidence: 99%

Heritability estimates for psychotic symptom dimensions in twins with psychotic disorders

Rijsdijk

Gottesman

McGuffin

et al. 2010

American J of Med Genetics Pt B

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Factor analysis of psychotic symptoms frequently results in positive, negative, and disorganized dimensions, but heritability estimates have not yet been reported. Symptom dimensions are usually only measured in individuals with psychotic disorders. Here, it is valuable to assess influences acting via liability to psychosis and independent modifying effects. We estimated heritability for psychotic symptom dimensions, taking account of these issues. Two-hundred-and-twenty-four probandwise twin pairs (106 monozygotic, 118 same-sex dizygotic), where probands had psychoses, were ascertained from the Maudsley Twin Register in London (1948-1993). Lifetime history of DSM-III-R psychotic disorder and psychotic symptom dimensions was assessed from clinical records and research interviews and rated using the Operational Criteria Checklist. Estimates of heritability and environmental components of variance in liability were made with structural equation modeling using a causal-contingent common pathway model adapted for ascertainment from a clinical register. Significant heritability was found for DSM-III-R psychotic disorder (h² = 90%, 95%CI 68-94%) and the disorganized symptom dimension (h² = 84%, 95%CI 18-93%). The heritability for the disorganized dimension remained significant when influences acting through liability to psychosis were set to zero, suggesting that some influences on disorganization are modifying factors independent of psychosis liability. However, the relative extent of modifying factors versus influences acting through psychosis liability could not be clearly determined. To our knowledge, this study provides the first formal evidence of substantive heritability for the disorganized symptom dimension, and suggests that genetic loci influencing disorganization in individuals with psychoses are in some cases different from loci that influence risk of psychotic disorders themselves.

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“…Reviews of genetic studies into delusional disorder [136,137] have found that due to a lack of studies and various methodological difficulties, there has been no clear evidence for or against a genetic contribution to the aetiology of delusional disorder. They found no linkage studies of delusional disorder that had been carried out.…”

Section: Other Psychotic Disordersmentioning

confidence: 99%

Genetics of Schizophrenia and other Psychotic Disorders

Pepper¹,

Cardno²

2014

CPSR

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Abstract:Research into the genetic basis of schizophrenia is advancing rapidly. This review gives a broad overview of results from successive phases of studies in this field, linking these with recent findings and likely future research directions. Among recent findings, large-scale epidemiological studies based on Scandinavian population registers, have provided further evidence of substantial heritability and evidence that a wide range of psychotic and non-psychotic disorders partly share genetic risk factors with schizophrenia. In molecular genetics, large collaborative genomewide association studies (GWAS) are providing evidence of common risk variants, each of small effect, and many more variants are likely to be found as samples sizes increase further. A range of rarer chromosomal copy number variants (CNVs) have been associated with schizophrenia, and both GWAS and CNV studies have provided molecular evidence of genetic overlap between schizophrenia and other disorders. There is increasing interest in phenotypes beyond diagnosis, including further clinical variables and endophenotypes. Next-generation sequencing studies are beginning, with the potential for fast, inexpensive sequencing of the whole genome in large samples, and there is an increasing focus on the functional effects of the candidate risk variants that are being identified.

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Genetics and delusional disorder

Cited by 16 publications

References 35 publications

The Clinical and Sociodemographic Profile of Persistent Delusional Disorder

The Clinical and Sociodemographic Profile of Persistent Delusional Disorder

Heritability estimates for psychotic symptom dimensions in twins with psychotic disorders

Genetics of Schizophrenia and other Psychotic Disorders

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