Genetics and genomics in <scp>T</scp>hailand: challenges and opportunities

Shotelersuk, Vorasuk; Limwongse, Chanin; Mahasirimongkol, Surakameth

doi:10.1002/mgg3.83

Cited by 19 publications

(21 citation statements)

References 35 publications

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“…To maximize the opportunity, we have acquired sequencers with long‐read, short‐read and linked‐read technologies, established high‐performance computer at National Science and Technology Development Agency (NSTDA) and Chulalongkorn University, developed programs to manage and analyze genomics data, and created exome and genome databases of Thai populations (manuscripts under preparation). Nonetheless, a shortage of man power in all relevant fields has made the realization of precision medicine in our country challenging (Shotelersuk, Limwongse, & Mahasirimongkol, ). Here, we summarize the current status of the adoption of precision medicine in various spheres and provide our perspectives on its future in Thailand.…”

Section: Precision Medicine In Thailand: Current Status and Applicationsmentioning

confidence: 99%

Precision medicine in Thailand

Shotelersuk

Tongsima

Pithukpakorn

et al. 2019

American J of Med Genetics Pt C

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Extraordinary advances in high throughput next generation sequencing (NGS) technology and bioinformatics are the main thrust that transforms the current state of healthcare into the era of precision medicine where clinical practice takes individual variability into account. Here, we summarize the current status of the infrastructure we have and the adoption of precision medicine in Thailand in four spheres: rare diseases, oncology, pharmacogenomics, and noncommunicable diseases. Moreover, we provide our perspectives to the future of precision medicine in Thailand, especially the manpower and ethical, legal, and social issues. We believe that with decreasing costs of NGS, increasing ability to interpret the genomic data, a greater number of actionable and available treatments, implementation of precision medicine at the public health level is not a matter of if but when. K E Y W O R D Snoncommunicable diseases, pharmacogenomics, precision medicine, precision oncology, rare diseases, Thailand

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Section: Precision Medicine In Thailand: Current Status and Applicationsmentioning

confidence: 99%

Precision medicine in Thailand

Shotelersuk

Tongsima

Pithukpakorn

et al. 2019

American J of Med Genetics Pt C

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“…The clinical geneticist to population ratio is estimated to be 1: 4, 000, 000 (Shotelersuk et al 2014;National Statistical Office 2016), and there are no in-country practicing genetic counselors specifically employed to serve the Thai people. At present, healthcare professionals such as nurses provide the needed service in maternal and child health centers.…”

Section: Thailandmentioning

confidence: 99%

“…At present, healthcare professionals such as nurses provide the needed service in maternal and child health centers. With the number of patients diagnosed with thalassemia in Thailand and the support of the Thalassemia Foundation of Thailand, the Ministry of Public Health has proposed the policy to prevent and control Thalassemia disease (Shotelersuk et al 2014). It is currently estimated that about 1% of Thai people have Thalassemia disease and about 35% are carriers of Thalassemia (Wanapirak et al 2004).…”

Section: Thailandmentioning

confidence: 99%

A Report on Ten Asia Pacific Countries on Current Status and Future Directions of the Genetic Counseling Profession: The Establishment of the Professional Society of Genetic Counselors in Asia

Laurino

Leppig

Abad

et al. 2017

Journal of Genetic Counseling

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The Professional Society of Genetic Counselors in Asia (PSGCA) was recently established as a special interest group of the Asia Pacific Society of Human Genetics. Fostering partnerships across the globe, the PSGCA's vision is to be the lead organization that advances and mainstreams the genetic counseling profession in Asia and ensures individuals have access to genetic counseling services. Its mission is to promote quality genetic counseling services in the region by enhancing practice and curricular standards, research and continuing education. The PSGCA was formally launched during the Genetic Counseling Pre-Conference Workshop held at the 11th Asia-Pacific Conference on Human Genetics in Hanoi, Viet Nam, September 16, 2015. The pre-conference workshop provided an opportunity for medical geneticists and genetic counselors from across 10 Asia Pacific countries to learn about the varied genetic counseling practices and strategies for genetic counseling training. This paper provides an overview of the current status and challenges in these countries, and proposed course of unified actions for the future of the genetic counseling profession.

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“…However, tests that have undergone health technology assessments and are found to be cost-effective for the health-care system satisfy the criteria for reimbursement in part or entirely by universal health care (UHC). Regrettably, most of the health-care systems currently pass on the expense of genetic tests to the individuals, and even for countries with comprehensive UHC, such as the United Kingdom, Singapore and Thailand, 41 the spectrum of reimbursable pharmacogenomic tests is still typically limited to only a handful of cancerrelated and HLA-targeted 34 pharmacogenetics tests (eg HLA-B*15:02 testing in Singapore and Thailand).…”

Section: Costs Of Pharmacogenomic Tests To the Individualsmentioning

confidence: 99%

Role of pharmacogenetics in public health and clinical health care: a SWOT analysis

2016

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Pharmacogenomics has been lauded as an important innovation in clinical medicine as a result of advances in genomic science. As one of the cornerstones in precision medicine, the vision to determine the right medication in the right dosage for the right treatment with the use of genetic information has not exactly materialised, and few genetic tests have been implemented as the standard of care in health systems worldwide. Here we review the findings from a SWOT analysis to examine the strengths, weaknesses, opportunities and threats around the role of pharmacogenetics in public health and clinical health care, at the micro, meso and macro levels corresponding to the perspectives of the individuals (scientists, patients and physicians), the health-care institutions and the health systems, respectively.

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Genetics and genomics in Thailand: challenges and opportunities

Cited by 19 publications

References 35 publications

Precision medicine in Thailand

Precision medicine in Thailand

A Report on Ten Asia Pacific Countries on Current Status and Future Directions of the Genetic Counseling Profession: The Establishment of the Professional Society of Genetic Counselors in Asia

Role of pharmacogenetics in public health and clinical health care: a SWOT analysis

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