Genetics and Neurobiology of Circadian Clocks in Mammals

Siepka, Sandra M.; Yoo, Seung-Hee; Park, Junghea; Lee, Choogon; Takahashi, Joseph S.

doi:10.1101/sqb.2007.72.052

Cited by 96 publications

(81 citation statements)

References 44 publications

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“…A variety of shift systems have been implemented, and it is predicted that in the near future that night shifts will become more common in many economic fields (1). Disturbances of the human day-night rhythm due to night work can cause desynchronization of internal biological clocks that govern most functions of the body (2). The neurohormone melatonin plays a major role in linking light perception with chronobiology and its secretion can be influenced by exposure to light at night (LAN) (3,4).…”

mentioning

confidence: 99%

Night work and breast cancer – results from the German GENICA study

Pesch¹,

Harth²,

Rabstein³

et al. 2009

Scand J Work Environ Health

118

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mentioning

confidence: 99%

Night work and breast cancer – results from the German GENICA study

Pesch¹,

Harth²,

Rabstein³

et al. 2009

Scand J Work Environ Health

118

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“…These indicate the existence of per2-independent mechanism(s) for circadian rhythms. Circadian rhythms are maintained by several molecular mechanisms [16]. Therefore, our results raise a possibility that per2 disruption in per2-mutant mice may activate other circadian mechanisms, which in turn may influence the circadian change in mRNA expressions.…”

Section: Discussionmentioning

confidence: 89%

Circadian rhythms of angiogenic factors in skin and wound tissue in per2-mutant mice

Hoshi¹,

Toukairin²,

Arai³

et al. 2017

Biomed Res Clin Prac

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It has recently been reported that circadian gene Period 2 (per2) regulates mRNA expression of vascular endothelial growth factor gene (Vegf) in some tumor cells. It still remains unknown, however, whether per2 has an effect on expression of angiogenic factors during the wound healing process. To investigate the circadian rhythms of angiogenic factors in intact skin and wound tissue in per2-mutant and control mice, we used a skin incision wound model on per2-mutant and control mice, and analyzed circadian rhythms of mRNA levels for several angiogenic factors. Our results show a novel finding that, for some angiogenic factors, the circadian rhythms of mRNA levels in wound tissue exist in per2-mutant as well as in control mice, indicating that some circadian rhythms may be per2-independent. We observed circadian rhythms of per2 and some angiogenic factor mRNAs in control mouse intact skin. The circadian patterns of some angiogenic factors mRNAs in intact skin were altered in per2-mutant mice relative to normal mice, indicating the existence of per2-dependent and independent regulations of angiogenic factors expressions.

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“…35 Synchronization to the 24-hour day, both internal (within the body) and external (to the light-dark cycle), is the major role of pineal melatonin in all species. Exogenous melatonin is thus used to minimize jet lag and synchronize other circadian rhythm disorders, particularly in blind subjects.…”

Section: Functions Of Melatoninmentioning

confidence: 99%

Melatonin and its use in atherosclerosis and dyslipidemia

Danilenko¹,

Ragino²

2013

CPT

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A review of pineal melatonin synthesis, regulation, and physiological effects indicates that not only does melatonin act as a hormonal signal of darkness, but also that it possesses antioxidant and anti-inflammatory properties. Although oxidation and inflammation play a pivotal role in atherogenesis, no studies have investigated administration of melatonin for human arterial atherosclerosis. However, 13 clinical trials have investigated use of melatonin in dyslipidemia, which is a close correlate of atherosclerosis. The results of these clinical trials, particularly the five that are placebo-controlled, are inconclusive as to whether melatonin can normalize the blood lipid profile. Significant confounders in these studies might be a phase shift of the cholesterol rhythm by melatonin, a posture effect at venipuncture, uncontrolled diet during the course of melatonin intake, and the phenomenon of regression to the mean. Thus, future studies are required, which should also consider use of higher doses of melatonin and/or measurement of oxidized forms of cholesterol-containing particles (which are the most aggressive in relation to atherogenesis) in addition to lipidic fractions.

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Genetics and Neurobiology of Circadian Clocks in Mammals

Cited by 96 publications

References 44 publications

Night work and breast cancer – results from the German GENICA study

Night work and breast cancer – results from the German GENICA study

Circadian rhythms of angiogenic factors in skin and wound tissue in per2-mutant mice

Melatonin and its use in atherosclerosis and dyslipidemia

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