Genetics, molecular control and clinical relevance of habituation learning

Blok, Laura E.R.; Boon, Marina; Reijmersdal, Boyd van; Höffler, Kira Daniela; Fencková, Michaela; Schenck, Annette

doi:10.1016/j.neubiorev.2022.104883

Cited by 7 publications

(2 citation statements)

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“…Drosophila models of ID are frequently characterized by deficits in habituation, which allows organisms to adapt to and ultimately ignore familiar, irrelevant stimuli, preserving cognitive capacities ( 31 , 48 , 49 ). In the light-off jump habituation paradigm, many ID models fail to suppress their jump response to repeated light-off stimuli, paralleling habituation deficits to different modalities reported in individuals with ASD and monogenic ID syndromes ( 31 , 50 ).…”

Section: Resultsmentioning

confidence: 99%

KDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism in neurons

Yheskel,

Hatch,

Pedrosa

et al. 2024

Nucleic Acids Research

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Genes encoding the KDM5 family of transcriptional regulators are disrupted in individuals with intellectual disability (ID). To understand the link between KDM5 and ID, we characterized five Drosophila strains harboring missense alleles analogous to those observed in patients. These alleles disrupted neuroanatomical development, cognition and other behaviors, and displayed a transcriptional signature characterized by the downregulation of many ribosomal protein genes. A similar transcriptional profile was observed in KDM5C knockout iPSC-induced human glutamatergic neurons, suggesting an evolutionarily conserved role for KDM5 proteins in regulating this class of gene. In Drosophila, reducing KDM5 changed neuronal ribosome composition, lowered the translation efficiency of mRNAs required for mitochondrial function, and altered mitochondrial metabolism. These data highlight the cellular consequences of altered KDM5-regulated transcriptional programs that could contribute to cognitive and behavioral phenotypes. Moreover, they suggest that KDM5 may be part of a broader network of proteins that influence cognition by regulating protein synthesis.

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Section: Resultsmentioning

confidence: 99%

KDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism in neurons

Yheskel,

Hatch,

Pedrosa

et al. 2024

Nucleic Acids Research

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“…A recent review focusing on the genetic and molecular changes involved in habituation in general illustrated the complexity of the mechanism of action and molecules involved in habituation. In this review, various cellular pathways were highlighted, and the identification of 258 genes were reported as possible targets for drugs [ 64 ]. From this perspective, future research could investigate the effects of many more candidate drugs and their effect on habituation (and sensitization) to pain.…”

Section: Treatments and Clinical Implicationsmentioning

confidence: 99%

Habituation to Pain in Patients with Chronic Pain: Clinical Implications and Future Directions

Miesen

Vossen

Joosten

2023

JCM

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In this review, the latest insights into habituation to pain in chronic pain are summarized. Using a systematic search, results of studies on the evidence of habituation to (experimental) pain in migraine, chronic low back pain, fibromyalgia, and a variety of chronic pain indications are presented. In migraine, reduced habituation based on self-report and the EEG-based N1 and N2–P2 amplitude is reported, but the presence of contradictory results demands further replication in larger, well-designed studies. Habituation to pain in chronic low back pain seems not to differ from controls, with the exception of EEG measures. In fibromyalgia patients, there is some evidence for reduced habituation of the N2–P2 amplitude. Our analysis shows that the variability between outcomes of studies on habituation to pain is high. As the mechanisms underlying habituation to pain are still not fully understood and likely involve several pathways, it is now too early to conclude that habituation to pain is related to clinical outcomes and can be used as a diagnostic marker. The review ends with a discussion on future directions for research including the use of standard outcome measures to improve comparisons of habituation to pain in patients and controls, as well as a focus on individual differences.

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EEG Biomarkers for Autism: Rational, Support, and the Qualification Process

Hudac,

Webb

2024

Advances in Neurobiology

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Genetics, molecular control and clinical relevance of habituation learning

Cited by 7 publications

References 322 publications

KDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism in neurons

KDM5-mediated transcriptional activation of ribosomal protein genes alters translation efficiency to regulate mitochondrial metabolism in neurons

Habituation to Pain in Patients with Chronic Pain: Clinical Implications and Future Directions

EEG Biomarkers for Autism: Rational, Support, and the Qualification Process

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