Genetics of asthma☆☆☆★

Wiesch, Denise G.; Meyers, Deborah A.; Bleecker, Eugene R.

doi:10.1016/s0091-6749(99)70065-5

Cited by 92 publications

(65 citation statements)

References 61 publications

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“…The incidence of childhood asthma seems to be increasing despite improved treatments over the last few decades [1]. The development of asthma is a complex interaction between environmental and genetics factors [3]. It is defined as a chronic inflammatory disorder with bronchial hyperresponsiveness (BHR) that leads to recurrent episodes of wheezing, breathlessness, chest tightness and coughing, particularly at night or in the early morning, and it is usually associated with widespread, but variable, airflow obstruction within the lungs, which is reversible either spontaneously or with treatment [4].…”

Section: Introductionmentioning

confidence: 99%

ThePCDH1gene and asthma in early childhood

et al. 2013

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Previous studies have suggested that variants in the protocadherin-1 (PCDH1) gene, which is important for cell-cell adhesion, are associated with asthma, bronchial, hyperresponsiveness and atopic dermatitis in school children.Our aim was to associate common variants of the PCDH1 gene with longitudinally assessed asthma phenotypes and atopic dermatitis in early childhood. We analysed eight single-nucleotide polymorphisms in PCDH1 from 411 children born to asthmatic mothers from the Copenhagen Prospective Studies on Asthma in Childhood birth cohort. Asthma and atopic dermatitis were diagnosed prospectively to the age of 7 years and asthma was categorised by temporal pattern: transient early respiratory symptoms, persistent symptoms and late-onset symptoms. Bronchial responsiveness was measured at age 6 years. We used additive genetic models.Kaplan-Meier plots revealed early onset in hetero-and homozygotes for the rs10063472-T allele. Significant association was observed between the transient early phenotype and rs10063472-T (transient early versus all: OR 1.91, 95% CI 1.21-3.01, p50.0058; transient early versus asymptomatic: OR 2.00, 95% CI 1.23-3.25, p50.0053). No association was observed for other symptom patterns or bronchial responsiveness. Significant association was observed for atopic dermatitis and rs11167761-A (OR 1.85, 95% CI 1.24-2.75, p50.0026).Common variations in PCDH1 increase the risk of developing both transient early asthma and atopic dermatitis in early childhood. @ERSpublications Common variations in the PCDH1 gene increase the risk of developing both asthma and atopic dermatitis in early life http://ow.ly/sjbNL For editorial comments see page 671.

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Section: Introductionmentioning

confidence: 99%

ThePCDH1gene and asthma in early childhood

et al. 2013

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“…[1][2][3][4] Evidence clearly indicates that a family history of asthma imposes an increased risk for childhood asthma. 1,5,6 Asthma results from the genetic predisposition in combination with exposure to environmental stimuli, 7 such as allergens 8 and cigarette smoke. 9,10 Elevated serum immunoglobulin E (IgE) levels measured during the first year of life have been associated with subsequent allergy 11 and asthma.…”

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confidence: 99%

Onset and Persistence of Childhood Asthma: Predictors From Infancy

et al. 2001

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ABSTRACT.Objective. In a prospective study of children with a family history of asthma, asthma onset by 3 years of age was found previously to be positively associated with variables from the first year of life, including elevated total immunoglobulin E (IgE), frequent respiratory infections, and parenting difficulties. We followed this cohort of genetically at-risk children to investigate the relationship between factors assessed in infancy and asthma, allergy, and psychological status at school age.Methods. A cohort of 150 children who were at risk for developing asthma were identified prenatally on the basis of the mothers' having asthma. For 28 children, the father had asthma as well, putting them at bilateral genetic risk. Families primarily were middle and upper middle class Caucasians. Parents came to the clinic during the third trimester of pregnancy for assessments of medical and psychosocial functioning. A home visit took place when the infant was 3 weeks old, when parenting risk was assessed before the onset of any asthma symptoms. Parenting difficulties included problems with infant caregiving as well as components of maternal functioning, such as postpartum depression and inadequate marital support. Blood was drawn for serum IgE at 6 months of age. Parents and offspring subsequently came to the clinic multiple times, with the last clinic visit during the child's sixth year. Follow-up at age 6 involved a clinic visit for allergy and psychosocial evaluations, consisting of interviews and a behavior questionnaire. Seventy-seven children received the allergy and psychosocial evaluation, 26 received the psychosocial evaluation in the clinic, and 30 families received telephone interviews and mailed in questionnaires. Additional monitoring of families by telephone and mail was maintained over the next 2 years, until the children were 8, to ensure accurate characterization of the course of illness. Comprehensive medical records were obtained and reviewed for all health care contacts. Children were designated as having asthma when there was documentation in medical records of physician-diagnosed asthma, observed wheezing, and/or prescription of asthma medications during the time period when the child was between 6 and 8 years of age. Parental reports of the occurrence of asthma corroborated the medical record data.Results. Data regarding asthma status were available for 145 children through 8 years of age. Forty (28%) of the children manifested asthma between 6 and 8 years of age. Among variables previously reported to predict asthma onset by age 3, 3 proved to have significant univariate relationships with asthma between ages 6 and 8: elevated IgE levels measured when the children were 6 months of age, global ratings of parenting difficulties measured when infants were 3 weeks old, and higher numbers of respiratory infections in the first year of life. Among these offspring of mothers with asthma, paternal asthma showed a significant association with asthma between ages 6 and 8. Eczema in the first year was...

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“…Mas é-nos muito difícil prever como e quando. [15][16][17] De tudo o que focámos outras questões se nos levantam: estaremos no início de um novo Génesis? Agora artificial?…”

Section: -15unclassified

Pneumologia: Retrospetiva do Século XX e Perspetiva para o Século XXI

Almeida

2018

Gaz Med

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A reflexão incluída neste número da Gazeta Médica, sobre as "Perspetivas da Pneumologia", carece de duas breves considerações que possibilitem a sua contextualização.Em primeiro lugar a escolha do tema. Compreende-se e justifica-se que incida na Pneumologia.Não sendo uma especialidade recente, pois tem as suas raízes na Tisiologia -com uma "passagem" de três a quatro décadas pela Pneumotisologia, mas tendo desde sempre despertado enorme interesse a clínicos e investigadores, e beneficiando do inegável progresso científico e tecnológico a que temos vindo a assistir, particularmente, na segunda metade do séc XX e no atual, esperar-se-ia que, como noutras, a morbilidade e mortalidade por doenças respiratórias mostrasse, pelo menos, o início do seu declínio.Mas os dados epidemiológicos contrariam este raciocí-nio e chamam-nos a atenção para o aumento da incidên- cia e prevalência das doenças crónicas obstrutivas das vias aéreas (doença pulmonar obstrutiva crónica, asma, bronquiectasias, entre outras), das doenças neoplásicas (que poderão vir a integrar o grupo das doenças cróni-cas) ou no campo da infeciologia das pneumonias (que continuam a ter elevada mortalidade, particularmente nas populações de idade mais avançada). Para mencionarmos, apenas, algumas das mais frequentes.Por outro lado, não podemos deixar de recordar que uma das características do Ser Humano é a da reflexão sobre o seu passado, sobre o caminho que percorreu, os problemas com que se deparou, os obstáculos que enfrentou e como os superou, quer no seu percurso sejam contemplados aspetos pontuais ou restritos, ou a multiplicidade dos que influenciaram a sua evolução natural.Dela procura tirar ilações e tenta perspetivar o futuro.O tema que nos foi atribuído situa-se nesta linha de pensamento e de conduta.76 · GAZETA MÉDICA Nº3 · VOL. 3 · JULHO/SETEMBRO 2016

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Genetics of asthma☆☆☆★

Cited by 92 publications

References 61 publications

ThePCDH1gene and asthma in early childhood

ThePCDH1gene and asthma in early childhood

Onset and Persistence of Childhood Asthma: Predictors From Infancy

Pneumologia: Retrospetiva do Século XX e Perspetiva para o Século XXI

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