Genetics of chronic pancreatitis

Chronic pancreatitis, pseudotumors and other tumor-like lesions

“…[80][81][82] The third gene with mutations associated with chronic pancreatitis is the cystic fibrosis gene, CFTR. Mutations in the first two genes, PRSS1 and SPINK1, seem to trigger the autoactivation of trypsinogen in the pancreas, which in turn results in the early inappropriate activation of the other pancreatic enzymes with subsequent autodigestive necrosis and inflammation.…”