Genetics of chronic rhinosinusitis: State of the field and directions forward

Hsu, Joy; Avila, Pedro C.; Kern, Robert C.; Hayes, M. Geoffrey; Schleimer, Robert P.; Pinto, Jayant M.

doi:10.1016/j.jaci.2013.01.028

Cited by 109 publications

(112 citation statements)

References 156 publications

(275 reference statements)

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“…Investigators have nevertheless suggested a number of candidate genes associated with CRS, which has led to some interesting observations with intriguing implications. Reviews of genetics of CRS [615][616][617] have been presented elsewhere and identified genes are presented as a tabulated list (Table VII- 10).…”

Section: Discussionmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

557

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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Section: Discussionmentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

557

888

View full text Add to dashboard Cite

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“…Numerous genetic polymorphisms have been statistically associated to CRS, mainly on the cystic fibrosis transmembrane conductance regulator gene (CFTR), as well as genes involved in antigen presentation, innate and adaptive immune responses, tissue remodeling, and arachidonic acid metabolism [95,96]. More recently, the association between CRS and some of these genetic variants has been replicated [97], and new genetic variations associated with CRS have been reported, such as those on the cluster of differentiation 8a (CD8A) gene [98] and the bitter taste receptor genes [99,100].…”

Section: Genetic Markersmentioning

confidence: 99%

Clinical and Biological Markers of Difficult-to-Treat Severe Chronic Rhinosinusitis

López-Chacón

Mullol

Pujols

2015

Curr Allergy Asthma Rep

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Chronic rhinosinusitis (CRS) is a chronic inflammatory disease of the upper airways of which two major phenotypes exist, CRS without nasal polyps (CRSsNP) and CRS with nasal polyps (CRSwNP). Some patients with CRS have suboptimal response to current guideline treatments. These patients remain severe and uncontrolled by treatment and have a poor quality of life. It is highly important to identify both clinical and biological markers, so-called biomarkers, in this subset of patients. The presence of nasal polyps and comorbidity with asthma and with aspirin-exacerbated respiratory disease (AERD) are the most common clinical traits that have been associated to difficult-to-treat severe CRS. In addition to clinical traits, numerous biological markers, with known etiopathogenic roles in CRS, have been associated to difficult-to-treat or recalcitrant CRS. This review summarizes the existing knowledge of the clinical and biological markers associated to difficult-to-treat or uncontrolled severe CRS.

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“…This view supports the hypothesis that a preliminary airway remodeling impedes an adequate inflammatory reaction. When considering the specific context of CRS, the most promising findings from candidate gene studies include the cystic fibrosis trans-membrane conductance regulator gene and the genes involved in tissue formation and maturation [10].…”

Section: Inflammation Induces Remodeling or Vice Versamentioning

confidence: 99%

Remodeling and Repair in Rhinosinusitis

Watelet

Dogné

Mullier

2015

Curr Allergy Asthma Rep

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Remodeling refers to the development of specific but potentially irreversible structural changes in tissue. Caucasian eosinophilic chronic rhinosinusitis (CRS) with polyps associated or not with cystic fibrosis was discriminated by edema from CRS without nasal polyps, characterized by extensive fibrotic fields. However, changes in epithelial and extracellular matrix structures are common findings in all types of chronic inflammatory diseases of upper airways, but rarely specific and highly variable in extend. Recent studies have shown that remodeling in CRS appears to occur in parallel, rather than purely subsequent to inflammation. Furthermore, some preferential remodeling associations can be recognized. Tremendous efforts have been put in research on coagulation factors, cytokines, growth factors, and proteases supporting all phases of upper airway remodeling. The current exploration of other CRS sub-groups and of the particular link with concomitant asthma aims to optimize the classification of CRS and its staging modes and to develop novel therapies.

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Genetics of chronic rhinosinusitis: State of the field and directions forward

Cited by 109 publications

References 156 publications

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Clinical and Biological Markers of Difficult-to-Treat Severe Chronic Rhinosinusitis

Remodeling and Repair in Rhinosinusitis

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