Genetics of Glioblastoma in Moroccan population: Review of literature

Abstract

Glioblastoma is the most aggressive malignant type of central nervous system tumors. The literature review revealed that the most common genetic abnormalities in primary and secondary glioblastomas are IDH1 / 2 mutations, p53 mutations, and overexpression of EGFR.To our knowledge, this is the first Moroccan study to provide a global picture of genetic studies performed on Moroccan patients to describe genetic markers and their frequency in our population.An in-depth research in ScienceDirect and Pubmed on glioblastoma articles treated in Morocco, this research is based on the following keywords: glioblastoma in Morocco, primary glioblastoma in Morocco, secondary glioblastoma in Morocco.We found only three research articles on genomic alteration of IDH1 / 2, p53 and EGFR expression. The frequency of these gene mutations in our population was similar to those reported from other populations.Additional molecular studies need to be performed on other genes to describe other genetic markers in the Moroccan population.

Angiotensin-converting enzyme insertion/deletion gene polymorphisms and the risk of glioma in an Algerian population

“…No similar studies were found in North Africa. For instance, a Moroccan study summarized 3 research works with 65, 62 and 34 patients, on the frequency of altered genes in patients with glioblastoma, where only alteration of IDH1/2, p53 and EGFR expression were analysed [27]. The frequency of these gene mutation in Moroccan population was similar to those reported from other populations.…”