Genetics of Hypertension: What Is Next?

Horani, Tariq; Best, Robert G.; Edwards, Elizabeth; DiPette, Donald J.

doi:10.1007/s12170-014-0429-y

Cited by 7 publications

(1 citation statement)

References 38 publications

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“…These may both predispose individuals to hypertension and play important roles in how certain antihypertensive drugs, such as those that mediate the renin‐angiotensin‐aldosterone system (RAAS) system, lower blood pressure. However, in spite of our growing knowledge, the application of genetics to predicting persons at risk for hypertension has not lived up to expectations …”

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confidence: 99%

Genetics of hypertension: Implications of single nucleotide polymorphism(s) in African populations and beyond

Skeete

DiPette

2018

J of Clinical Hypertension

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confidence: 99%

Genetics of hypertension: Implications of single nucleotide polymorphism(s) in African populations and beyond

Skeete

DiPette

2018

J of Clinical Hypertension

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Historical redlining and cardiovascular health: The Multi-Ethnic Study of Atherosclerosis

Mujahid

Gao

Tabb

et al. 2021

Proc. Natl. Acad. Sci. U.S.A.

110

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We investigated historical redlining, a government-sanctioned discriminatory policy, in relation to cardiovascular health (CVH) and whether associations were modified by present-day neighborhood physical and social environments. Data included 4,779 participants (mean age 62 y; SD = 10) from the baseline sample of the Multi-Ethnic Study of Atherosclerosis (MESA; 2000 to 2002). Ideal CVH was a summary measure of ideal levels of seven CVH risk factors based on established criteria (blood pressure, fasting glucose, cholesterol, body mass index, diet, physical activity, and smoking). We assigned MESA participants’ neighborhoods to one of four grades (A: best, B: still desirable, C: declining, and D: hazardous) using the 1930s federal Home Owners’ Loan Corporation (HOLC) maps, which guided decisions regarding mortgage financing. Two-level hierarchical linear and logistic models, with a random intercept to account for participants nested within neighborhoods (i.e., census tracts) were used to assess associations within racial/ethnic subgroups (non-Hispanic White, non-Hispanic Black, Hispanic, and non-Hispanic Chinese). We found that Black adults who lived in historically redlined areas had a 0.82 (95% CI −1.54, −0.10) lower CVH score compared to those residing in grade A (best) neighborhoods, in a given neighborhood and adjusting for confounders. We also found that as the current neighborhood social environment improved the association between HOLC score and ideal CVH weakened (P < 0.10). There were no associations between HOLC grade and CVH measures or effect modification by current neighborhood conditions for any other racial/ethnic group. Results suggest that historical redlining has an enduring impact on cardiovascular risk among Black adults in the United States.

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Cardiovascular safety of anti-diabetic drugs

Kumar

Kerins

Walther

2015

Eur Heart J Cardiovasc Pharmacother

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Cardiovascular disease is the leading cause of morbidity and mortality among patients with diabetes, underscoring the importance of choosing anti-diabetic drugs that do not increase cardiovascular risk but might reduce the risk of cardiovascular events. Most type 2 diabetic patients die from cardiovascular causes despite the beneficial effects of blood pressure (BP) and lipid-lowering medications. The prevalence of patients with cardiovascular disease and diabetes mellitus is growing exponentially. Approximately 40% of patients hospitalized with heart failure and reduced ejection fraction have diabetes mellitus. The recent trials conducted in patients with heart failure who had diabetes showed a different response to standard medication, with these patients being more prone to develop side effects than patients with the same degree of heart failure but without diabetes mellitus. Therefore, careful selection of drug therapy paying particular attention to cardiovascular safety is important in optimizing diabetic therapy. This review discusses the efficacy and safety of the most commonly prescribed anti-diabetic drugs in the context of cardiovascular impact.

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Genetics of Hypertension: What Is Next?

Cited by 7 publications

References 38 publications

Genetics of hypertension: Implications of single nucleotide polymorphism(s) in African populations and beyond

Genetics of hypertension: Implications of single nucleotide polymorphism(s) in African populations and beyond

Historical redlining and cardiovascular health: The Multi-Ethnic Study of Atherosclerosis

Cardiovascular safety of anti-diabetic drugs

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