2008
DOI: 10.1007/s11892-008-0025-y
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Genetics of metabolic syndrome

Abstract: Metabolic syndrome (MetS) is a common phenotype, affecting about 24% of the US population. It is associated with an increased risk for type 2 diabetes and cardiovascular disease. Although there is no universally accepted definition for MetS, affected individuals commonly have a cluster of features, including abdominal obesity, hypertension, dyslipidemia, and dysglycemia. Recently, there has been extensive interest in potential genetic contributions to MetS. At present, no single gene or cluster of genes has be… Show more

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Cited by 58 publications
(50 citation statements)
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“…Due to space limitations, we focus only on the genetic determinants of dyslipidemia that overlap with MetSyn defined as a single, unifying trait and refer the reader to other reviews for genetic determinants of the other traits involved in MetSyn (Joy et al, 2008;Monda et al, 2010;Sharma and McNeill, 2006) and their interactions with lifestyle factors (Adamo and Tesson, 2008;Garaulet et al, 2009;Ordovas and Shen, 2008;Phillips et al, 2008) and toxins (Andreassi, 2009). Lipoprotein related genes with common SNPs associated with MetSyn (as defined by NCEP ATP III and AHA/NHLBI criteria) and HDL-C, LDL-C or TG levels include APOA5 and APOC3 (Table 4) (Grallert et al, 2007;Joy et al, 2008;Miller et al, 2007;Yamada et al, 2008). Enzymes involved in lipid metabolism with genetic polymorphisms that have also been associated with MetSyn (using the NCEP ATPIII criteria) appear limited to the nonsynonymous SNP in LPL, rs328 (Table 4) (Joy et al, 2008; www.intechopen.com Komurcu-Bayrak et al, 2007).…”
Section: Genetic Variants In Dyslipidemia and The Metabolic Syndrome mentioning
confidence: 99%
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“…Due to space limitations, we focus only on the genetic determinants of dyslipidemia that overlap with MetSyn defined as a single, unifying trait and refer the reader to other reviews for genetic determinants of the other traits involved in MetSyn (Joy et al, 2008;Monda et al, 2010;Sharma and McNeill, 2006) and their interactions with lifestyle factors (Adamo and Tesson, 2008;Garaulet et al, 2009;Ordovas and Shen, 2008;Phillips et al, 2008) and toxins (Andreassi, 2009). Lipoprotein related genes with common SNPs associated with MetSyn (as defined by NCEP ATP III and AHA/NHLBI criteria) and HDL-C, LDL-C or TG levels include APOA5 and APOC3 (Table 4) (Grallert et al, 2007;Joy et al, 2008;Miller et al, 2007;Yamada et al, 2008). Enzymes involved in lipid metabolism with genetic polymorphisms that have also been associated with MetSyn (using the NCEP ATPIII criteria) appear limited to the nonsynonymous SNP in LPL, rs328 (Table 4) (Joy et al, 2008; www.intechopen.com Komurcu-Bayrak et al, 2007).…”
Section: Genetic Variants In Dyslipidemia and The Metabolic Syndrome mentioning
confidence: 99%
“…Lipoprotein related genes with common SNPs associated with MetSyn (as defined by NCEP ATP III and AHA/NHLBI criteria) and HDL-C, LDL-C or TG levels include APOA5 and APOC3 (Table 4) (Grallert et al, 2007;Joy et al, 2008;Miller et al, 2007;Yamada et al, 2008). Enzymes involved in lipid metabolism with genetic polymorphisms that have also been associated with MetSyn (using the NCEP ATPIII criteria) appear limited to the nonsynonymous SNP in LPL, rs328 (Table 4) (Joy et al, 2008; www.intechopen.com Komurcu-Bayrak et al, 2007). Several SNPs in the LDLR have been associated with MetSyn (using AHA/NHLBI criteria) and LDL-C or HDL-C (Joy et al, 2008;Yamada et al, 2008 …”
Section: Genetic Variants In Dyslipidemia and The Metabolic Syndrome mentioning
confidence: 99%
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“…At 48 d after weaning, significantly higher values were observed for colon length and muscle mass in the offspring of prebiotic-fed dams (1·2 (SE 0·1) cm/cm and 5·7 (SE 1·8) mg/g, respectively), compared with control offspring (1·1 (SE 0·1) cm/cm and 2·9 (SE 0·9) mg/g, respectively), without any difference in spleen and stomach weight, or serum leptin concentration. The present preliminary study suggests that altering the fibre content of the maternal diet during both pregnancy and lactation enhances offspring growth, through an effect on intestinal and muscle mass rather than fat mass accretion.Key words: Prebiotics: Gestation: Development: NeonatesThe prevalence of the metabolic syndrome, as defined by the combination of abdominal obesity, impaired glucose tolerance, dyslipidaemia and hypertension (1) , is increasing throughout the world. This syndrome is associated with an increased risk of CVD and type 2 diabetes (1) .…”
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confidence: 99%
“…This syndrome is associated with an increased risk of CVD and type 2 diabetes (1) . The pathophysiology of the metabolic syndrome is clearly multifactorial, and besides the direct impact of dietary imbalance, there is considerable evidence that adverse environmental influences during early development may increase disease risk in later life (2) .…”
mentioning
confidence: 99%