Genetics of Migraine - Is There any Progress?

Klimov, Eugene; Kondratieva, Natalia; Анучина, А.А.; Skorobogatykh, Kirill; Azimova, Julia; Сергеев, А. В.; Наумова, Е. А.; Рудько, О.И.; Кокаева, З.Г.; Soboleva, Anna; Соболев, В. В.; Tabeeva, G. R.

doi:10.15406/jnsk.2017.07.00245

Cited by 2 publications

(1 citation statement)

References 127 publications

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“…These variants hint towards a remarkable progress in this direction and provide causes for optimism that the key mechanisms for this disorder can finally be understood. Thus, migraine-related GWAS and reported metaanalyses found different SNPs for this disease, which can be further classified into five pathways [20] on the bases of function:…”

Section: Migraine and Its Snpsmentioning

confidence: 99%

Role of single nucleotide polymorphisms (SNPs) in common migraine

Kaur

Ali

Ahmad

et al. 2019

Egypt J Neurol Psychiatry Neurosurg

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Single nucleotide polymorphisms (SNPs) may act as biological markers, as they can relate to the genes that are associated with various complex diseases such as heart diseases, diabetes, cancer, schizophrenia, blood pressure, migraine, and Alzheimer. These SNPs mostly locate within a gene or in a regulatory region near a gene and can affect the gene's function to play a more direct role in disease. Hence, SNPs allow scientists to develop candidate drug therapy by evaluating an individual's genetic makeup to develop a particular disease. Gene-gene interactions generally complicate migraine and its genetics and further gene-environmental interactions that often misguide the true defying causes of this disease. Due to its complex nature, it is difficult for scientists to reveal a complete list of SNPs or even all the genes that are related with the pathogenesis of this disease. Nowadays, much work has been done in this direction and new variants of migraine are being constantly identified. In this review article, the role of various SNPs reported to be disease-associated in published migraine GWAS has been discussed. To understand the molecular mechanisms of migraine attack by identifying new genetic variants of migraine can be a key to develop new therapeutic strategies in the future.

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Section: Migraine and Its Snpsmentioning

confidence: 99%

Role of single nucleotide polymorphisms (SNPs) in common migraine

Kaur

Ali

Ahmad

et al. 2019

Egypt J Neurol Psychiatry Neurosurg

View full text Add to dashboard Cite

show abstract

Analysis of Genome Wide Associated Variants rs2651899 (PRDM16), rs11172113 (LRP1), and rs10166942 (TRPM8) of Migraine in the Indian Episodic Migraineurs

Manickam,

Ramasamy

2023

Journal of Datta Meghe Institute of Medical Sciences University

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Background: The involvement of genes in migraine pain is identified by several studies. Many genome-wide association studies (GWAS) revealed the presence of particular variants in different migraine populations worldwide. Objective: This study aims in analyzing the presence of 3 GWAS variants (rs2651899 [PRDM16], rs11172113 [LRP1], and rs10166942 Transient Receptor Potential Cation Channel Subfamily M Member 8 [TRPM8]) in the Indian episodic migraineurs. Methodology: Enrolled 200 age- and gender-matched patients and control volunteers; collected blood samples to isolate DNA to check the presence of chosen variants in them. The results obtained were statistically analyzed using SPSS version 26.0. Results: The rs10166942 (TRPM8) variant is observed in 1.5% of control, 15.88% of migraine with aura, and 5.37% of migraine without aura subjects with the highly significant P < 0.0008. The other two variants are absent in the chosen sample group. Conclusion: We reported the presence of rs10166942 in the Indian episodic migraineurs and we recommend pathway analysis for confirming its association with the migraine pain progression.

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Genetics of Migraine - Is There any Progress?

Cited by 2 publications

References 127 publications

Role of single nucleotide polymorphisms (SNPs) in common migraine

Role of single nucleotide polymorphisms (SNPs) in common migraine

Analysis of Genome Wide Associated Variants rs2651899 (PRDM16), rs11172113 (LRP1), and rs10166942 (TRPM8) of Migraine in the Indian Episodic Migraineurs

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