Genetics of preeclampsia: paradigm shifts

Oudejans, Cees B.M.; Dijk, Marie van; Oosterkamp, Marjet; Lachmeijer, Augusta M. A.; Blankenstein, Marinus A.

doi:10.1007/s00439-006-0259-1

Cited by 97 publications

(70 citation statements)

References 31 publications

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“…Furthermore, Rahimi et al (2013) confirmed that the ACE D allele and DD genotype were more associated with increased risk of mild preeclampsia (1.99-and 2.34-fold respectively) than severe preeclampsia (1.61-and 1.56-fold respectively), similar to the results of the study by Mandò et al (2009). These results substantiated the theory that severe and mild preeclampsia patients are characterized by genetic heterogeneity (Oudejans et al 2007). Furthermore, they demonstrated that the ID genotype of ACE is associated with lower total antioxidant capacity levels compared with the II genotype, which suggested the lipid peroxidation and oxidative stress, known to be involved in the pathogenesis of preeclampsia, and this might be influenced by polymorphisms in the genes.…”

Section: Ace Polymorphism In Preeclampsiasupporting

confidence: 81%

The role of the renin–angiotensin–aldosterone system in preeclampsia: genetic polymorphisms and microRNA

Yang¹,

Shang²,

Zhang³

et al. 2013

Journal of Molecular Endocrinology

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The compensatory alterations in the rennin-angiotensin-aldosterone system (RAAS) contribute to the salt-water balance and sufficient placental perfusion for the subsequent well-being of the mother and fetus during normal pregnancy and is characterized by an increase in almost all the components of RAAS. Preeclampsia, however, breaks homeostasis and leads to a disturbance of this delicate equilibrium in RAAS both for circulation and the uteroplacental unit. Despite being a major cause for maternal and neonatal morbidity and mortality, the pathogenesis of preeclampsia remains elusive, where RAAS has been long considered to be involved. Epidemiological studies have indicated that preeclampsia is a multifactorial disease with a strong familial predisposition regardless of variations in ethnic, socioeconomic, and geographic features. The heritable allelic variations, especially the genetic polymorphisms in RAAS, could be the foundation for the genetics of preeclampsia and hence are related to the development of preeclampsia. Furthermore, at a posttranscriptional level, miRNA can interact with the targeted site within the 3 0 -UTR of the RAAS gene and thereby might participate in the regulation of RAAS and the pathology of preeclampsia. In this review, we discuss the recent achievements of genetic polymorphisms, as well as the interactions between maternal and fetal genotypes, and miRNA posttranscriptional regulation associated with RAAS in preeclampsia. The results are controversial but utterly inspiring and attractive in terms of potential prognostic significance. Although many studies suggest positive associations with genetic mutations and increased risk for preeclampsia, more meticulously designed large-scale investigations are needed to avoid the interference from different variations.

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Section: Ace Polymorphism In Preeclampsiasupporting

confidence: 81%

The role of the renin–angiotensin–aldosterone system in preeclampsia: genetic polymorphisms and microRNA

Yang¹,

Shang²,

Zhang³

et al. 2013

Journal of Molecular Endocrinology

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“…Genetic factors are thought to have a role in getting the disease [18,19]. Observations that suggest this are that women who are pregnant for the first time and have a family history of preeclampsia have a higher risk of getting it than women who are pregnant for the first time and do not have a family history of preeclampsia [20].…”

Section: Genetic Factorsmentioning

confidence: 99%

Preeclampsia: Pathophysiology and the Maternal-Fetal Risk

Khalil¹

2017

J Hypertens Manag

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“…1 Clinical observations suggest that earlyonset and late-onset disease types can be separated in origin, even though individual cases share characteristics. 3 The progression of the disease is unpredictable and may lead to a convulsive phase, eclampsia. The removal of the affected placenta through delivery is the only known treatment for pre-eclampsia.…”

Section: Introductionmentioning

confidence: 99%

A follow-up linkage study of Finnish pre-eclampsia families identifies a new fetal susceptibility locus on chromosome 18

et al. 2013

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Pre-eclampsia is a common vascular disorder of pregnancy. It originates in the placenta and targets the maternal endothelium. According to epidemiological research, 450% of the liability to this disorder can be accounted for by genetic factors. Both maternal and fetal genes contribute to the risk, but especially the fetal genetic risk profile is still poorly understood. We have previously detected linkage signals in multiplex Finnish families on chromosomes 2p25, 4q32, and 9p13 using maternal phenotypes. We performed a linkage analysis using updated maternal phenotypes and an unprecedented linkage analysis using fetal phenotypes. Markers genotyped were available from 237 individuals in 15 Finnish families, including 72 affected mothers and 49 affected fetuses. The MERLIN software was used for sample and marker quality control and linkage analysis. The results were compared against the original ones obtained by using the GENEHUNTER 2.1 software. The previous identification of the maternal susceptibility locus to a genetic location at 21.70 cM near marker D2S168 on chromosome 2 was confirmed by using both maternal and fetal phenotypes (maternal non-parametric linkage (NPL) score 3.79, P ¼ 0.00008, LOD (logarithm (base 10) of odds) ¼ 2.20 and fetal NPL score 2.95, P ¼ 0.002, LOD ¼ 1.71). As a novel finding, we present a suggestive linkage to chromosome 18 at 86.80 cM near marker D18S64 (NPL score 2.51, P ¼ 0.006, LOD ¼ 1.20) using the fetal phenotype. We propose that chromosome 18 may harbor a new fetal susceptibility locus for pre-eclampsia.

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Genetics of preeclampsia: paradigm shifts

Cited by 97 publications

References 31 publications

The role of the renin–angiotensin–aldosterone system in preeclampsia: genetic polymorphisms and microRNA

The role of the renin–angiotensin–aldosterone system in preeclampsia: genetic polymorphisms and microRNA

Preeclampsia: Pathophysiology and the Maternal-Fetal Risk

A follow-up linkage study of Finnish pre-eclampsia families identifies a new fetal susceptibility locus on chromosome 18

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