Genetics of rat hypodactyly

Křenová, D; Jirsová, Z; Bı́lá, V; Kaspárek, R; Pravenec, Michal; Křen, Vladimı́r

doi:10.1016/s0939-8600(00)80028-0

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…Rat autosomal recessive hypodactylous (Hd) mutation leads to male sterility of the homozygotes, which is associated with a significant decrease in the number of germ cells 1,2 . The present study was aimed at establishing whether increased germ cell degeneration during differentiation of seminiferous epithelium is a dominant cause of this disorder.…”

Section: Introductionmentioning

confidence: 99%

Altered Spermatogenesis in the Hypodactylous Rats

Jirsová¹,

Kučera²,

Martínek³

et al. 2004

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Germinal epithelium of seminiferous tubules in adult, infertile hypodactylous males displays significant reduction in the number of germ-line cells. Detection of apoptosis in the germ-line cells during postnatal differentiation was performed to elucidate the mechanism of the decreased number of germ cells in the testes of adult rats. Evaluation of DNA fragmentation and expression of activated caspase-3 in germ cells did not confirm marked germ cell death during the onset of spermatogenesis as a main cause of significant reduction of germ cells in Hd/Hd testes of adult males. The primary cause of spermatogenesis defect seems to be rather associated with a disorder in the cell cycle regulation and interrelation of germ-line cells with Sertoli cells.

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Section: Introductionmentioning

confidence: 99%

Altered Spermatogenesis in the Hypodactylous Rats

Jirsová¹,

Kučera²,

Martínek³

et al. 2004

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Impact of genetic engineering on the understanding of spermatogenesis

Escalier

2001

Human Reproduction Update

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To date, about 100 genes have been found, by genetic engineering, to be implicated in spermatogenesis. Primordial germ cells, spermatogonia, spermatocytes I and elongating spermatids are particularly sensitive. Transgenic and knockout mice permit an approach to be made to the question of genetic factors involved in DNA damage repair, thermal injury, sperm chromatin compaction and sex-specific recombination. Knockout mice reveal unexpected functional redundancies of testis-specific genes. This review considers how functional divergences can exist among homologous genes from different species, and to what extent the phenotypes of knockout mice can be similar to those from spontaneous mutations. Additional anomalies in reproductive function have frequently been found in these mice, as were found factors leading to tumour susceptibility and/or various diseases. Finally, knockout mice remind us that, in nearly all cases, hemizygous individuals retain a fertility and a wild-type sperm phenotype, although half of the spermatozoa share a genetic defect. The findings strongly emphasize the importance of understanding epidemiology in male infertility, to identify hereditary forms of impaired spermatogenesis, and to create DNA and pathological germ cell banks.

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Genetics of rat hypodactyly

Cited by 2 publications

References 4 publications

Altered Spermatogenesis in the Hypodactylous Rats

Altered Spermatogenesis in the Hypodactylous Rats

Impact of genetic engineering on the understanding of spermatogenesis

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