Genetics of schizophrenia: communicating scientific findings in the clinical setting

Roos, J.L.

doi:10.4314/ajpsy.v14i2.1

Cited by 4 publications

(6 citation statements)

References 19 publications

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“…This clear pathway from research to practice is at the heart of D&I via the inclusion of multiple stakeholders (parents, children patients, and clinicians). Similarly, Roos [142] discussed the role of genomics, recurrent risk, and family history in clinical care for schizophrenia, as did Vortsman and colleagues [143] when discussing the implementation of pharmacotherapy into the clinical care of autism spectrum disorder. Finally, Hendershot [141] offered a rare discussion of when and how to implement genomic information (i.e., pharmacogenomics) into evidence-based practice guidelines for alcohol use disorder and that there is a need for efficient, not just effective, translation.…”

Section: Part 1: Emphasizing Linear Translational Frameworkmentioning

confidence: 99%

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Four Actionable Bottlenecks and Potential Solutions to Translating Psychiatric Genetics Research: An Expert Review

Bourdon

Davies

Long

2020

Public Health Genomics

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Background: Psychiatric genetics has had limited success in translational efforts. A thorough understanding of the present state of translation in this field will be useful in the facilitation and assessment of future translational progress. Purpose: A narrative literature review was conducted. Combinations of 3 groups of terms were searched in EBSCOhost, Google Scholar, and PubMed. The review occurred in multiple steps, including abstract collection, inclusion/exclusion criteria review, coding, and analysis of included papers. Results: One hundred and fourteen articles were analyzed for the narrative review. Across those, 4 bottlenecks were noted that, if addressed, may provide insights and help improve and increase translation in the field of psychiatric genetics. These 4 bottlenecks are emphasizing linear translational frameworks, relying on molecular genomic findings, prioritizing certain psychiatric disorders, and publishing more reviews than experiments. Conclusions: These entwined bottlenecks are examined with one another. Awareness of these bottlenecks can inform stakeholders who work to translate and/or utilize psychiatric genetic information. Potential solutions include utilizing nonlinear translational frameworks as well as a wider array of psychiatric genetic information (e.g., family history and gene-environment interplay) in this area of research, expanding which psychiatric disorders are considered for translation, and when possible, conducting original research. Researchers are urged to consider how their research is translational in the context of the frameworks, genetic information, and psychiatric disorders discussed in this review. At a broader level, these efforts should be supported with translational efforts in funding and policy shifts.

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Section: Part 1: Emphasizing Linear Translational Frameworkmentioning

confidence: 99%

“…The research on translating the genetic epidemiology of psychiatric disorders [5, 6, 126, 139, 140, 142, 155] is scarce. Occasionally, the translation of both genetic epidemiology and molecular genomics are discussed together [75, 153, 156, 157].…”

Section: Part 2: Relying On Molecular Genomic Informationmentioning

confidence: 99%

Four Actionable Bottlenecks and Potential Solutions to Translating Psychiatric Genetics Research: An Expert Review

Bourdon

Davies

Long

2020

Public Health Genomics

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“…We administered the positive and negative syndrome scale (PANSS) to measure severity of psychotic symptoms. These scales have been widely used locally in genetics and treatment studies [ 3 , 19 – 22 ]. The Camberwell assessment of needs scale (CAN) was used to measure met and unmet needs [ 23 ].…”

Section: Main Textmentioning

confidence: 99%

Improving adherence in mental health service users with severe mental illness in South Africa: a pilot randomized controlled trial of a treatment partner and text message intervention vs. treatment as usual

et al. 2017

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ObjectivesMedication non-adherence is a significant problem in treatment of severe mental disorders and is associated with poor clinical outcomes and increased demand on services. Task-shifting interventions incorporating mobile health may improve adherence in mental health service users in low- and middle-income countries. Seventy-seven participants were recruited from a psychiatric hospital in Cape Town, with 42 randomized to receive the intervention and 35 to treatment as usual. Intervention pairs underwent treatment-partner contracting and psychoeducation, and received monthly text message reminders of clinic appointments. Primary outcomes were intervention acceptability and feasibility. Secondary outcome for efficacy were adherence to clinic visit; relapse; quality of life; symptomatic relief and medication adherence.ResultsTreatment partner and psychoeducation components were acceptable and feasible. The text message component was acceptable but not feasible in its current form. Efficacy outcomes favoured the intervention but did not reach statistical significance. A treatment-partner intervention is acceptable and feasible in a low- and middle-income setting. Work is needed to ensure that additional components of such interventions are tailored to the local context. Appropriately powered efficacy studies are needed. Trial Registration PACTR PACTR201610001830190, Registered 21 October 2016 (Retrospectively registered)Electronic supplementary materialThe online version of this article (10.1186/s13104-017-2915-z) contains supplementary material, which is available to authorized users.

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“…Due to the complexity of psychiatric disorders PGC is among the most challenging topics encountered in clinical practice. Professional education is needed to better prepare psychiatrists to provide PGC in a manner that will assist patients and families to better understand the genetics of schizophrenia ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Psychiatric genetic counseling for patients with schizophrenia and their families

Kotzé

Zwide

2022

Front. Psychiatry

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Steady progress in the field of psychiatric genetics, generating new and fascinating insight into the genetic and phenotypic complexity of schizophrenia and other serious mental illnesses, have created an increased need of psychiatric genetic counseling. It is a crucial aspect of psychiatric clinical practice to ensure a balanced approach that takes into consideration genetic and environmental risk factors and ongoing education in this rapidly developing field is essential. Genetic counseling will be increasingly important to assist patients with schizophrenia and their families to make a meaningful informed decision about genetic testing. It will preempt unrealistic expectations, discrimination and stigma related to incomplete understanding of genetic test results in the psychiatric context.

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Genetics of schizophrenia: communicating scientific findings in the clinical setting

Cited by 4 publications

References 19 publications

Four Actionable Bottlenecks and Potential Solutions to Translating Psychiatric Genetics Research: An Expert Review

Four Actionable Bottlenecks and Potential Solutions to Translating Psychiatric Genetics Research: An Expert Review

Improving adherence in mental health service users with severe mental illness in South Africa: a pilot randomized controlled trial of a treatment partner and text message intervention vs. treatment as usual

Psychiatric genetic counseling for patients with schizophrenia and their families

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