Genetics of the antibody response to an endothelial transplantation antigen in the rat

Blankert, J.J.; Es, Leendert A. van; Kunz, Heinz W.; Cramer, Donald V.; Paul, Leendert C.

doi:10.1016/0198-8859(86)90021-2

Cited by 9 publications

(5 citation statements)

References 24 publications

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“…The kinetics and the strength of the antibody response strongly resembled the response observed upon transplantation of BN kidney allografts in unilaterally nephrectomized MAXX recipients [2], It therefore appears that the RTl (in)compatibility between the donor and the recipient had no demonstrable effect on the formation of antibodies against Eag-1. This conclusion is in accordance with previous experiments using allogeneic lymphoid cells, which showed that the humoral response against Eag-1 is determined by the class II region of the recipient's RTl complex and independent of RTl (in)compatibility between donor and recipient [3]. However, the conclusion appears to contradict the clinical observation that EM antibodies are preferentially produced in HLA-DR-incompatible donor-recipient combinations [1].…”

Section: Discussionsupporting

confidence: 89%

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Role of the Endothelial Antigen Eag‐1 in the Rejection of Rat Kidney Allografts

et al. 1988

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The immunogenicity of the minor histocompatibility antigen Eag-1 of the rat kidney endothelium was studied in renal allografts mismatched for antigens of the major histocompatibility complex (MHC). The rejection rates of BN.1L (RT1(1), Eag-1+), (BN.1LXMAXX)F1 (RT1l/n, Eag-1+), and LEW (RT1l, Eag-1-) kidneys transplanted into unsensitized, bilaterally nephrectomized MAXX (RT1n, Eag-1-) recipients were comparable, indicating that incompatibility for Eag-1 has no effect on the survival of MHC-incompatible kidney grafts. Transplantation of BN (RT1n, Eag-1+) and WKY (RT1k, Eag-1+) kidneys into unilaterally nephrectomized MAXX recipients led to a weak and inconsistent antibody response against Eag-1, indicating that MHC incompatibility does not influence the formation of antibodies against Eag-1.

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Section: Discussionsupporting

confidence: 89%

“…Analysis of sera. Post-transplantation sera were collected every week and studied by indirect immunofluorescence with frozen kidney sections as described previously [3].…”

Section: Methodsmentioning

confidence: 99%

Role of the Endothelial Antigen Eag‐1 in the Rejection of Rat Kidney Allografts

et al. 1988

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“…B lymphocytes and the vascular endothelium (19) are reby ns ib1e for initiating the vascular lesions. In rats, a non-C endothelial antigen, Eag-I, is capable of stimulating the roduction of allospecific antibodies that bind to vascular enthelium, (20) and the antigen has been indirectly associated with renal rejection (21). The strains used in these studies differ for Eag-I, BN expressing the antigen and the DA and J)A.lI strains being negative.…”

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confidence: 99%

Cardiac Transplantation in the Rat

et al. 1989

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The development of arteriosclerosis is the most serious and common complication in long-term survivors of cardiac transplantation. We have used a variety of inbred rat strains with selected histocompatibility differences to examine the influence of prolonged, mild rejection reactions on the development of pathological changes in long-term cardiac allografts. Heterotopic cardiac allografts were exchanged between rat strains that differed for MHC class I (RT1.A and/or RT1.E) antigens or groups of minor, non-MHC antigens in MHC-compatible congenic combinations. Our results demonstrate that in strain combinations in which the allograft reaction is mild and prolonged, the donor hearts exhibit pathological changes that include a diffuse, interstitial myocardial fibrosis, perivascular fibrosis, and intimal proliferation in arteries of the graft myocardium. The lesions were less prominent in animals with more active rejection and infrequent in strains that differ for class I histocompatibility antigens or syngeneic controls. These results suggest that the comparable pathological changes seen in long-term human cardiac survivors may reflect low-level, persistent allograft reactions rather than factors associated with graft anoxia or effects of immunotherapy to prevent graft rejection.

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“…Interesting is the short-time occurrence and disappearance of such antibodies spontaneously or after treatment (Okudaira et al 1982b, Romagnani et al 198.5); autoreactive antibodies in SLE patients sometimes exert similar features. The transient appearance of autoreactive MHC (RT1)-specific antibodies in the rat was observed by Blankert et al (1985). The occurrence of an HLA-A2-restricted anti-H-Y antibody (van Leeuwen et al 1979) was also transient.…”

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confidence: 99%

Natural autoreactive H‐2‐specific serum antibodies in a group of BALB/cBy (H‐2^d) mice

et al. 1986

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Natural autoreactive H‐2‐specific antibodies were detected by lymphocytotoxic test in sera of 15 BALB/cBy (H‐2d) mice maintained in the same cage. The antibodies could be detected only for a short period of time; they reacted strongly with H‐2d and H‐2s and weakly with H‐2k,q,r cells. Such antibodies could not be identified in sera of other groups of mice of the same strain maintained in the same environment. All serum‐positive mice had a shorter life span than control mice. However, neither a real link between the antibodies and the disease nor a clear understanding of the disease was achieved.

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Genetics of the antibody response to an endothelial transplantation antigen in the rat

Cited by 9 publications

References 24 publications

Role of the Endothelial Antigen Eag‐1 in the Rejection of Rat Kidney Allografts

Role of the Endothelial Antigen Eag‐1 in the Rejection of Rat Kidney Allografts

Cardiac Transplantation in the Rat

Natural autoreactive H‐2‐specific serum antibodies in a group of BALB/cBy (H‐2^d) mice

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Genetics of the antibody response to an endothelial transplantation antigen in the rat

Cited by 9 publications

References 24 publications

Role of the Endothelial Antigen Eag‐1 in the Rejection of Rat Kidney Allografts

Role of the Endothelial Antigen Eag‐1 in the Rejection of Rat Kidney Allografts

Cardiac Transplantation in the Rat

Natural autoreactive H‐2‐specific serum antibodies in a group of BALB/cBy (H‐2d) mice

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Natural autoreactive H‐2‐specific serum antibodies in a group of BALB/cBy (H‐2^d) mice