Genetische Instabilität der Hämolysin/Bacteriocin-Bildung bei &lt;i&gt;Streptococcus fæcalis var. zymogenes&lt;/i&gt;

Marder, H.P.; Kayser, Fritz H.

doi:10.1159/000162774

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“…In the isolates of clinical origin, we frequently observed cotransfer of hemolysin and bacteriocin production with one of the drug resistance determinants. These observations are consistent with the view that bacteriocin and hemolysin production are linked genetically and mediated by plasmids (9,13,19,29) and that some particular bacteriocins and hemolysins ofS. faecalis are identical substances (1,2) or probably coded by the same gene (13).…”

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confidence: 91%

Drug Resistance in Group D Streptococci of Clinical and Nonclinical Origin: Prevalence, Transferability, and Plasmid Properties

Embden

Engel

Klingeren

1977

Antimicrob Agents Chemother

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Group D streptococci isolated from clinical specimens and from sewage were investigated with regard to resistance to tetracycline (Tc), erythromycin (Em), and chloramphenicol (Cm). The median values of the percentages of resistant strains from sewage were: for Tc, 14%; for Em, 2.8%; and for Cm, 0.1%. For the recent isolates of clinical origin, resistance percentages found were 58% for Tc, 12% for Em, and 14% for Cm, and, in comparison to clinical isolates from 1964, the incidence of drug resistance slightly increased. In strains of both sources, the drug resistance was often found to be transferable to another group D streptococcus, probably by conjugation. Two strains were able to transfer their Em resistance to a streptococcus strain of group B. No transfer of drug resistance to a group A streptococcus and Escherichia coli was observed. All beta-hemolytic streptococci were also bacteriocinogenic, and frequently these properties were found to be transferable. The function, size, and base composition of the plasmids of two drug-resistant Streptococcus faecalis strains were investigated; strain M439 harbors at least two conjugative plasmids: pRI401, molecular weight 30 × 10 6 , coding for Tc resistance, and pRI402, molecular weight 41 × 10 6 , coding for Em resistance. Strain M403 carries one single conjugative plasmid species, coding for Tc resistance. The molecular weight of this plasmid, pRI404, was 37 × 10 6 . The guanine plus cytosine content of these plasmids was 35 to 36%.

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confidence: 91%

Drug Resistance in Group D Streptococci of Clinical and Nonclinical Origin: Prevalence, Transferability, and Plasmid Properties

Embden

Engel

Klingeren

1977

Antimicrob Agents Chemother

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Transferable Plasmids Mediating Multiple-Antibiotic Resistance in Streptococcus faecalis subsp. liquefaciens

Marder

Kayser

1977

Antimicrob Agents Chemother

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In strain HK187 ( Streptococcus faecalis subsp. liquefaciens ) four plasmids were isolated. The molecular weights, as analyzed in neutral sucrose gradients and by electron microscopy, were found to be about 36 × 10 6 , 31 × 10 6 , 26 × 10 6 , and 4 × 10 6 . Plasmid 3, also designated pFK14, with a molecular weight of 26 × 10 6 , was found to be responsible for resistance to chloramphenicol and erythromycin and also for high-level resistance to streptomycin and lincomycin. In mixed cultures these four resistances could be transferred with high frequency to a plasmid-free recipient, S. faecalis strain JH2-2.

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Genetische Instabilität der Hämolysin/Bacteriocin-Bildung bei <i>Streptococcus fæcalis var. zymogenes</i>

Cited by 2 publications

References 0 publications

Drug Resistance in Group D Streptococci of Clinical and Nonclinical Origin: Prevalence, Transferability, and Plasmid Properties

Drug Resistance in Group D Streptococci of Clinical and Nonclinical Origin: Prevalence, Transferability, and Plasmid Properties

Transferable Plasmids Mediating Multiple-Antibiotic Resistance in Streptococcus faecalis subsp. liquefaciens

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